Sarcoidosis Diagnosed After September 11, 2001, Among Adults Exposed to the World Trade Center Disaster

Jordan, Hannah; Stellman, Steven D.; Prezant, David J.; Teirstein, Alvin S.; Osahan, Sukhminder; Cone, James E.

doi:10.1097/jom.0b013e31822a3596

Cited by 84 publications

(43 citation statements)

References 23 publications

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“…These findings support the hypothesis that a variety of environmental exposures, including those generated by the destruction of the World Trade Center, may cause sarcoidosis or sarcoid like granulomatous pulmonary disease. The fact that similar findings have been reported by two other cohort studies, FDNY and the WTC Registry [Jordan et al, 2008] provide additional evidence in support of this hypothesis. Further scientific study is needed to understand the geneticenvironmental interactions that may be responsible for the apparent relationship between WTC exposure and sarcoid like granulomatous disease.…”

Section: Resultssupporting

confidence: 80%

“Sarcoid like” granulomatous pulmonary disease in World Trade Center disaster responders

Crowley

Herbert

Moline

et al. 2010

American J Industrial Med

108

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Section: Resultssupporting

confidence: 80%

“Sarcoid like” granulomatous pulmonary disease in World Trade Center disaster responders

Crowley

Herbert

Moline

et al. 2010

American J Industrial Med

108

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“…[5] In the latter study, the incidence rate was highest in the first post-9/11 year (86/100,000), but decreased over the next 4 years to compare favorably with the age-adjusted rate we report: 22/100,000 vs. 25.4/100,000 in the current study. This rate is also similar to the annual incidence of 23.1/100,000 in white males reported by the WTC non-FDNY responder cohort.…”

Section: Discussionsupporting

confidence: 76%

“…To date, two of the three major cohorts of WTC-exposed rescue/recovery workers have reported “greater than expected” numbers of post-9/11 cases of sarcoidosis[3, 4] while the third reported an elevated sarcoidosis risk among specific WTC-exposed workers. [5]…”

Section: Introductionmentioning

confidence: 99%

Post-9/11 sarcoidosis in WTC-exposed firefighters and emergency medical service workers

Webber

Yip

Zeig‐Owens

et al. 2017

Respiratory Medicine

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Introduction The World Trade Center (WTC) disaster released a huge quantity and variety of toxicants into the environment. To-date, studies from each of the three major cohorts of WTC-exposed workers have suggested “greater than expected” numbers of post-9/11 cases in some workers. We undertook this study to estimate the incidence of post-9/11 sarcoidosis in ~13,000 male firefighters and EMS workers enrolled in The Fire Department of the City of New York (FDNY) WTC Health Program; to compare FDNY incidence to rates from unexposed, demographically similar men in the Rochester Epidemiology Project (REP); and, to examine rates by level of WTC exposure. Methods We calculated incidence of sarcoidosis diagnosed from 9/12/2001 to 9/11/2015, and generated expected sex- and age-specific rates based on REP rates. Standardized incidence ratios (SIR) based on REP rates, and 95% confidence intervals (95% CI) were estimated. Two sensitivity analyses limited cases to those with intra-thoracic symptoms or biopsy confirmation. Results We identified 68 post-9/11 cases in the FDNY cohort. Overall, FDNY rates were significantly higher than expected rates (SIR= 2.8; 95% CI= 2.2, 3.6). Including only symptomatic cases, the SIR decreased (SIR= 2.2; 95% CI=1.5, 3.0), but remained significantly elevated. SIRs ranged from 2.7 (95% CI=2.0, 3.5) in the lower WTC exposure group to 4.2 (95% CI=1.9, 8.0) in the most highly exposed. Conclusions We found excess incident post-9/11 sarcoidosis in WTC-exposed workers. Continued surveillance, particularly of those most highly exposed, is necessary to identify those with sarcoidosis and to follow them for possible adverse effects including functional impairments and organ damage.

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“…2 Nonetheless, a case-control study using World Trade Center Health Registry data found that working on the World Trade Center debris pile was associated with a significantly higher odds of sarcoidosis. 3 Because both cases and controls in that study underwent similar observation, surveillance bias should be limited.…”

Section: In Replydepidemiology Of Sarcoidosismentioning

confidence: 99%

Epidemiology of Sarcoidosis

Reich

2016

Mayo Clinic Proceedings

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Sarcoidosis Diagnosed After September 11, 2001, Among Adults Exposed to the World Trade Center Disaster

Abstract: Working on the WTC debris pile was associated with an elevated risk of post-9/11 sarcoidosis. Occupationally exposed workers may be at increased risk.

Cited by 84 publications

References 23 publications

“Sarcoid like” granulomatous pulmonary disease in World Trade Center disaster responders

“Sarcoid like” granulomatous pulmonary disease in World Trade Center disaster responders

Post-9/11 sarcoidosis in WTC-exposed firefighters and emergency medical service workers

Epidemiology of Sarcoidosis

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