Characteristics of poly(vinyl pyrrolidone)/poly(acrylic acid) interpolymer complex prepared by template polymerization of acrylic acid: Effect of reaction solvent and molecular weight of template

Abstract

Poly(vinyl pyrrolidone) (PVP)/poly(acrylic acid) (PAA) interpolymer complexes were prepared, in ethanol or dimethylformamide (DMF), by template polymerization of acrylic acid in the presence of PVP (MW: 42.5 or 1100 K) used as the template. FTIR analysis showed that the complexes were formed through hydrogen bonding between the carboxyl groups of the PAA and the carbonyl groups of the PVP. The glass-transition temperature (T g ) of the complex, prepared in ethanol, was higher than that of the component polymers, whereas the T g of the complex, prepared in DMF, was located between that of the component polymers. The dissolution rate of the complex was affected by the molecular weight of the PVP and the reaction solvent. The release rate of ketoprofen from the complexes showed a pH dependency, and was slower at a lower pH. The ketoprofen release rate from the complex was controlled mainly by the dissolution rate of the complex above the pK a of PAA (4.75) and by the diffusion rate below the pK a .

Preparation and characterization of hydrogels with potential for use as biomaterials

“…In recent years, polyacrylic acid (PAA) and its copolymers have often been used as carriers in drug release systems, because of their multifunctional nature, unique properties and good biocompatibility 13,14 . Several studies of the water swelling and drug release behaviours of poly(AA-co-VP) hydrogels have been reported [15][16][17] . In these hydrogels strong hydrogen bonds can be formed between the AA and VP constituents 16 .…”

“…Several studies of the water swelling and drug release behaviours of poly(AA-co-VP) hydrogels have been reported [15][16][17] . In these hydrogels strong hydrogen bonds can be formed between the AA and VP constituents 16 .…”

Application of FTIR spectroscopy for structural characterization of ternary poly(acrylic acid)–metal–poly(vinyl pyrrolidone) complexes

“…The solutions of (PVP) treated with transition metal chlorides FeCl 3 2 were added to (PAA), which was achieved by dissolving a certain weight of polymer (0.5 g) in fixed volume of distilled water (50 mL) and homogenated by stirring for 2 h. The precipitates were then filtered, washed with distilled water and air dried over 3 days at room temperature. The complexes were further dried at 608C in dry oven until maintaining constant weight.…”

“…[1][2][3][4][5][6][7][8] The cooperative interaction between synthetic water-soluble polymers has been a popular research topic because of their importance from both academic and applied viewpoints.…”

“…The FTIR spectra of the precipitates resulted from the mixtures of PVP-PAA and Ni(NO 3 ) 2 and Sr(NO 3 ) 2 are given in Figure 4. It was found that the addition of Ni(NO 3 ) 2 or Sr(NO 3 ) 2 to the mixture of the electrolytes of PAA and PVP causes changes in the characteristic spectral features of the complex resulting from the interpolymer interaction of the two polymers. The most striking changes are:…”