Characteristics of platelet indices, neutrophil-to-lymphocyte ratio and erythrocyte sedimentation rate compared with C reactive protein in patients with cerebral infarction: a retrospective analysis of comparing haematological parameters and C reactive protein

Abstract

ObjectiveElevation of C reactive protein (CRP) is one of the major acute-phase responses following ischaemic or haemorrhagic stroke. This study aims to investigate the associations between platelet indices, neutrophil-to-lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) compared with CRP in patients with cerebral infarction.SettingThe clinical data of patients with cerebral infarction were analysed retrospectively.ParticipantsWe analysed, unduplicated, 516 patients with cerebral infarction (mean age 66.2±12.7, male/female=291/225).Outcome measuresMean platelet volume (MPV), MPV to platelet count, NLR and ESR were compared with CRP in patients with cerebral infarction in a single institute through Spearman correlation test.ResultsThere were significant correlations between CRP and MPV (ρ=0.088, p=0.045), NLR (ρ=0.4, p<0.001) and ESR (ρ=0.468, p<0.001) in patients with cerebral infarction. In the male group, NLR (ρ=0.398, p<0.001) and ESR (ρ=0.502, p<0.001) showed significant correlations with CRP. In the female group, CRP showed significant correlations with MPV (ρ=0.17, p=0.011), NLR (ρ=0.392, p<0.001) and ESR (ρ=0.475, p<0.001).ConclusionsMPV, NLR and ESR showed significant correlation with CRP in patients with cerebral infarction. MPV and NLR are cost-effective and simple parameters that can be attainable by using an automatic haematology analyser. Further well-designed and large-scale prospective studies are warranted to evaluate platelet indices or NLR for monitoring patients with cerebral infarction.

Neutropenia and neutrophil‐to‐lymphocyte ratio in a healthy Korean population: race and sex should be considered

“…Lim et al . reported that CRP, ESR, and mean platelet volume were positively correlated with NLR in patients with cerebral infarction. Similar to their report, CRP was positively correlated with NLR in our study.…”

“…In rheumatoid arthritis, NLR correlates with the disease activity score and high values are associated with chronic conditions such as diabetes, as well as with smoking and increased age . In addition, compared to CRP, NLR is a more useful inflammatory parameter for evaluating patients with cerebral infarction .…”

Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

“…Neopterin and PBC-derived ratios have also been reported to represent biomarkers of atherosclerosis and complications accompanying atherosclerosis and to predict the risk of related events [7,[29][30][31][32][33][34][35]. Surprisingly, only limited information is currently available with regard to a correlation or comparison between PBC-derived ratios and other biomarkers of inflammatory response [41,42].…”

“…In addition, NLR and CRP have been reported to correlate in cancer patients [42] or patients suffering from the complications of atherosclerosis [41]. Significant correlations between NLR, LMR or PLR and urinary neopterin would be expected as PBC-derived ratios as well as serum or urinary neopterin concentrations accompany the inflammatory response induced by the host response against cancer.…”

Study the relationship between nasal polyps, platelet count, mean platelet volume, neutrophil/lymphocyte ratio in patients attending otolaryngology OPD in a tertiary care teaching hospital, West Bengal

“…43 A study on patients with stroke reported that NLR increase and CRP (C reactive protein) which is an inflammation marker are significantly correlated. 44 The study by Gokhan et al showed NLR scores increase significantly in ischemic and hemorrhagic stroke. 45 Because OSAS and cardiovascular diseases are frequently observed in patients with nasal polyps in which structure of neutrophil and lymphocytes play an important role, we have chosen to investigate the relationship between nasal polyps and NLR scores.…”