Characteristics of peripheral blood NK and NKT-like cells in euthyroid and subclinical hypothyroid women with thyroid autoimmunity experiencing reproductive failure

Mikó, Éva; Meggyes, Mátyás; Doba, Katalin; Farkas, Nelli; Bogar, Barbara; Barakonyi, Alíz; Szereday, László; Szekeres-Barthó, Júlia; Mezősi, Emese

doi:10.1016/j.jri.2017.09.008

Cited by 24 publications

(18 citation statements)

References 56 publications

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“…The first is that thyroid autoimmunity is an epiphenomenon; that is, it is a marker of generalized autoimmunity and not a pathogenic factor by itself. An altered immune status with enhanced natural cytotoxicity has been recently described in women with thyroid autoimmunity (45). The second hypothesis is that thyroid antibodies are directly pathogenic to ovarian tissue.…”

Section: Discussionmentioning

confidence: 99%

Thyroid and Fertility: Recent Advances

Dosiou

2020

Thyroid

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Background: Thyroid disease is prevalent in women of reproductive age, while infertility is common in women with thyroid dysfunction. In this study, we review the recent advances in the field of thyroid and fertility since the publication of the 2017 American Thyroid Association pregnancy guidelines. Summary: Recent studies have confirmed associations of thyrotropin (TSH) elevation and/or thyroid autoimmunity with infertility and low ovarian reserve in subsets of women, and have led to a better understanding of the pathogenesis linking thyroid autoimmunity with infertility. Even though the benefit of treating patients with TSH >4 mIU/L has been confirmed in a large retrospective cohort study, two large randomized controlled trials have failed to show benefit of thyroid hormone on obstetrical outcomes in euthyroid women with thyroid autoimmunity. New data have emerged regarding the potential gonadal toxicity of radioactive iodine (RAI), based on its impact on ovarian reserve and sperm chromosomal abnormalities. Conclusions: There is continued evidence supporting an important role of thyroid hormone in regulation of reproductive tissues at many levels. Recent randomized trials have failed to identify a benefit of thyroid hormone in euthyroid women with thyroid autoimmunity. Further research in the field is needed to more completely delineate the relevant pathways and identify women who may benefit from levothyroxine treatment. The impact of RAI on fertility also merits further investigation.

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Section: Discussionmentioning

confidence: 99%

Thyroid and Fertility: Recent Advances

Dosiou

2020

Thyroid

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“…The molecular mechanisms underlying the association between adverse pregnancy outcomes and the presence of thyroid antibodies are not fully understood, thus, theories have been proposed. According to the first, TAI serves as a marker of a general immune imbalance with the dysregulated activity of the immune system at the fetal-maternal interface via, both, direct and indirect ways [20,21,25]. The second theory states that women who otherwise have normal thyroid function but have tested positive for thyroid antibodies may progress to subclinical or overt hypothyroidism, resulting in a reduced ability of thyroid gland to adapt to the physiological changes of pregnancy [26,27] and leading to insufficient concentrations of circulating thyroid hormone for the given gestational age.…”

Section: Miscarriage Rate (Mr)mentioning

confidence: 99%

Does subclinical hypothyroidism and/or thyroid autoimmunity influence the IVF/ICSI outcome? Review of the literature

Safarian

Gzgzyan

Lyailya

et al. 2019

Gynecological Endocrinology

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While overt hypothyroidism is a well-known risk factor for infertility, the association of subclinical hypothyroidism (SCH) or thyroid autoimmunity and reproductive failure has been still not elucidated. In this literature review, the current data on the effect of SCH and/or thyroid autoimmunity and human reproduction is presented. The main ART outcome measures are as follows: number of oocytes retrieved, fertilization rate, implantation rate, clinical pregnancy rate per embryo transfer, embryo quality, miscarriage rate, and live birth rate. Current guidelines on the management of women with SCH and/or thyroid autoimmunity undergoing ART cycles will be presented in this review.

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“…However, in 2017 the American Society of Thyroid Guidelines recommended the upper reference limit of TSH to 4.0 mIU/L (Alexander et al ., 2017). There is no clear consensus on the efficacy of an upper value for TSH and the effects on fertility outcomes (Miko et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Impact of subclinical hypothyroidism and thyroid autoimmunity on clinical pregnancy rate after intrauterine insemination in euthyroid women

Pekcan

Özgü-Erdinç

Yılmaz

2019

JBRA Assisted Reproduction

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Objective: This study aimed to evaluate the association between subclinical hypothyroidism and thyroid autoantibodies with clinical pregnancy rate after intrauterine insemination (IUI) in euthyroid women. Methods: In this prospective cohort study, we recruited 497 women who underwent IUI treatment. We assessed thyroid function tests, thyroid antibodies and clinical pregnancy rates of the patients. Results: The patients were divided into two groups according to TSH values: normal group, n=387, and subclinical hypothyroidism group 2, n=110. The clinical pregnancy rate was 15.2% in the Control Group and 17.3% in the study group ( p =0.656). In the Study Group, 35% of the patients had anti-TPO positivity ( p =0.531) and 42.1% of the patients had anti-TG positivity ( p =0.285). There was no statistically significant difference in clinical pregnancy rates between the groups in terms of antithyroid antibody positivity ( p =0.54; p =0.559, respectively). Conclusion: Anti-TPO antibodies and subclinical hypothyroidism had no impact on clinical pregnancy rates in the women submitted to IUI.

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Characteristics of peripheral blood NK and NKT-like cells in euthyroid and subclinical hypothyroid women with thyroid autoimmunity experiencing reproductive failure

Cited by 24 publications

References 56 publications

Thyroid and Fertility: Recent Advances

Thyroid and Fertility: Recent Advances

Does subclinical hypothyroidism and/or thyroid autoimmunity influence the IVF/ICSI outcome? Review of the literature

Impact of subclinical hypothyroidism and thyroid autoimmunity on clinical pregnancy rate after intrauterine insemination in euthyroid women

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