Characteristics of Perforin Expressing Lymphocytes Within the First Trimester Decidua of Human Pregnancy

Rukavina, Daniel; Rubeša, Gordana; Gudelj, Lea; Haller, Herman; Podack, Eckhard R.

doi:10.1111/j.1600-0897.1995.tb00908.x

Cited by 67 publications

(51 citation statements)

References 29 publications

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“…Their role in normal pregnancy is, however, still controversial. CD16-negative, perforinpositive, but non-cytotoxic NK cells have been reported in first trimester human decidua [29]. Thus, the relative proportion of decidual NK cells is increased in normal pregnancy compared with the non-pregnant uterus.…”

Section: Reduced Nk Cell Activitymentioning

confidence: 96%

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Progesterone and the immunology of pregnancy

Druckmann¹,

Druckmann²

2005

The Journal of Steroid Biochemistry and Molecular Biology

255

143

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Section: Reduced Nk Cell Activitymentioning

confidence: 96%

“…Hence, there is a potential for the initiation of a vicious circle. The final mechanism by which activated NK cells kill their target cells is exocytosis of perforin and serine esterase -containing granules in the contact area between effector (LAK) and target (trophoblast) cells [29,48].…”

Section: Increased Nk Cell Activity and Lymphokine Activated Killer Cmentioning

confidence: 99%

Progesterone and the immunology of pregnancy

Druckmann¹,

Druckmann²

2005

The Journal of Steroid Biochemistry and Molecular Biology

255

143

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“…Under certain conditions, e.g., when exposed to hCMV-infected autologous decidual cells [58] or during spontaneous abortion in mice [59], they degranulate, but during normal pregnancy these cells are not cytotoxic despite the abundant presence of cytotoxic molecules in their cytoplasmic granules [60,61].…”

Section: Pibf Regulates Nk Activity During Pregnancymentioning

confidence: 99%

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

Szekeres-Barthó

2018

Med Princ Pract

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This review aims to provide a brief historical overview of the feto-maternal immunological relationship, which profoundly influences the outcome of pregnancy. The initial question posed in the 1950s by Medawar [Symp Soc Exp Biol. 1953; 7: 320–338] was based on the assumption that the maternal immune system recognizes the fetus as an allograft. Indeed, based on the association between HLA-matching and spontaneous miscarriage, it became obvious that immunological recognition of pregnancy is required for a successful gestation. The restricted expression of polymorphic HLA antigens on the trophoblast, together with the presence of nonpolymorphic MHC products, excludes recognition by both T and NK cells of trophoblast-presented antigens; however, γδ T cells, which constitute the majority of decidual T cells, are likely candidates. Indeed, a high number of activated, progesterone receptor-expressing γδ T cells are present in the peripheral blood of healthy pregnant women and, in the presence of progesterone, these cells secrete an immunomodulatory protein called progesterone-induced blocking factor (PIBF). As early as in the peri-implantation period, the embryo communicates with the maternal immune system via PIBF containing extracellular vesicles. PIBF contributes to the dominance of Th2-type reactivity which characterizes normal pregnancy by inducing increased production of Th2 cytokines. The high expression of this molecule in the decidua might be one of the reasons for the low cytotoxic activity of decidual NK cells.

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“…It has been reported that the lack of perforin expression in the uNK cells does not measurably restrain successful pregnancy and reproduction, i.e., perforin-deficient mothers were able to give birth to the same number of syngeneic or semi-allogeneic litters of similar sizes as control mice [11,16]. Our result also showed that although the cell population of uNK cells in P -/-mice was tended to be higher than B6 mice at Day 12, there is not significant difference between these 2 groups.…”

mentioning

confidence: 99%

Uterine Natural Killer Cells in Perforin and .BETA.2-Microglobulin Deficient Mice

Phichitrasilp

Hondo

Kusakabe

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Uterine natural killer (uNK) cells have roles for immune responses at the feto-maternal interface in mice. We studied the effects of β 2 -microglobulin (β 2 m) and perforin on proliferation and differentiation of uNK cells in pregnancy, using β 2 -microglobulindeficient (β 2 m -/-) mice and perforin-deficient (P -/-) mice. The cell population of uNK cells in the metrial gland of P -/-mice was tended to be higher than the control B6 mice. The cell population of uNK cells in the metrial gland of β 2 m -/-mice was significantly increased at Day 12 of pregnancy comparing to B6 and P -/-mice. On the other hand, the cell population of uNK cells in the decidua basalis of β 2 m -/-mice was tended to be lower than B6 and P -/-mice. These results indicate that β 2 m may be involved in proliferation of uNK cells in the metrial gland, and that β 2 m may affect the maturation of uNK cells in the decidua basalis. KEY WORDS: β 2 -microglobulin, perforin, uterine natural killer cell.

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Characteristics of Perforin Expressing Lymphocytes Within the First Trimester Decidua of Human Pregnancy

Cited by 67 publications

References 29 publications

Progesterone and the immunology of pregnancy

Progesterone and the immunology of pregnancy

The Role of Progesterone in Feto-Maternal Immunological Cross Talk

Uterine Natural Killer Cells in Perforin and .BETA.2-Microglobulin Deficient Mice

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