Progesterone and the immunology of pregnancy

Druckmann, René; Druckmann, Marc-Alexandre

doi:10.1016/j.jsbmb.2005.08.010

Cited by 255 publications

(166 citation statements)

References 48 publications

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“…However, as both 17β-estradiol and progesterone increase dramatically during pregnancy (33) and the effects of 17β-estradiol seem to be concentration-dependent (42), the influence of these hormones might well be different during pregnancy. Our study suggests that even though both progesterone and 17β-estradiol have important and well documented immune modulating effects on pregnancy (43,44) , these do not seem to be mediated via the promotion of Tregs.…”

Section: Discussionmentioning

confidence: 59%

Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17β-estradiol

Mjösberg

Svensson

Johansson

et al. 2009

Journal of Reproductive Immunology

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Section: Discussionmentioning

confidence: 59%

Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17β-estradiol

Mjösberg

Svensson

Johansson

et al. 2009

Journal of Reproductive Immunology

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“…However, as both 17␤-estradiol and progesterone increase dramatically during pregnancy (33) and the effects of 17␤-estradiol seem to be concentration dependent (42), the influence of these hormones might well be different during pregnancy. Our study suggests that even though both progesterone and 17␤-estradiol have important and well-documented immune-modulating effects on pregnancy (43,44), these do not seem to be mediated via the promotion of Tregs.…”

Section: Discussionmentioning

confidence: 61%

Systemic Reduction of Functionally Suppressive CD4dimCD25highFoxp3+ Tregs in Human Second Trimester Pregnancy Is Induced by Progesterone and 17β-Estradiol

Mjösberg

Svensson

Johansson

et al. 2009

The Journal of Immunology

135

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CD4+CD25high regulatory T cells (Tregs) are implicated in the maintenance of murine pregnancy. However, reports regarding circulating Treg frequencies in human pregnancy are inconsistent, and the functionality and phenotype of these cells in pregnancy have not been clarified. The aim of this study was to determine the frequency, phenotype, and function of circulating Tregs in the second trimester of human pregnancy and the influence of progesterone and 17β-estradiol on Treg phenotype and frequency. Based on expressions of Foxp3, CD127, and HLA-DR as determined by multicolor flow cytometry, we defined a proper CD4dimCD25high Treg population and showed, in contrast to most previous reports, that this population was reduced in second trimester of pregnancy. Unexpectedly, Foxp3 expression was decreased in the Treg, as well as in the CD4+ population. These changes could be replicated in an in vitro system resembling the pregnancy hormonal milieu, where 17β-estradiol, and in particular progesterone, induced, in line with the pregnancy situation, a reduction of CD4dimCD25highFoxp3+ cells in PBMC from nonpregnant women. By coculturing FACS-sorted Tregs and autologous CD4+CD25− responder cells, we showed that Tregs from pregnant women still displayed the same suppressive capacity as nonpregnant women in terms of suppressing IL-2, TNF-α, and IFN-γ secretion from responder cells while efficiently producing IL-4 and IL-10. Our findings support the view of hormones, particularly progesterone, as critical regulators of Tregs in pregnancy. Furthermore, we suggest that in the light of the results of this study, early data on circulating Treg frequencies in pregnancy need reevaluation.

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“…Regulation of the transport and stability 221" of gametes and early embryos in the oviduct requires the support of cell adhesion 222" molecules and, for this reason, it was possible to observe an increase in mRNA 223" expression of ITGA1 from 72 h. It is well known that interferons have a multipotential 224" role in the immune response through-out pregnancy. In particular, successful pregnancy 225" requires a protective immunomodulatory mechanism, including a reduction in 226" inflammatory and cytotoxic reactions mainly carried out via IFNG, IL-2 and TNF 227" (Druckmann & Druckmann, 2005). As the expression of IFNG is considered an 228" immunoreaction related to pregnancy failure, it could be posited that transcript 229" abundance was reduced significantly at 72 h in order to avoid embryo abortion.…”

Section: "mentioning

confidence: 99%

Oviductal and endometrial mRNA expression of implantation candidate biomarkers during early pregnancy in rabbit

Saeed¹,

Saenz-de-Juano

Marco‐Jiménez

et al. 2013

Zygote

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SummaryPrenatal losses are a complex problem. Pregnancy requires orchestrated communication between the embryo and the uterus that includes secretions from the embryo to signal pregnancy recognition and secretion and remodelling from the uterine epithelium. Most of these losses are characterized by asynchronization between embryo and uterus. To better understand possible causes, an analysis was conducted of gene expression of a set of transcripts related to maternal recognition and establishment of rabbit pregnancy (uteroglobin, SCGB1A1; integrin α1, ITGA1; interferon-γ, IFNG; vascular endothelial growth factor, VEGF) in oviduct and uterine tissue at 16, 72 or 144 h post-ovulation and insemination. In the oviduct tissue, a significant decrease in the level of SCGB1A1 mRNA expression was observed from 144 h post-ovulation. In the case of ITGA1, the transcript abundance was initially lower, but mRNA expression increased significantly at 72 and 144 h post-ovulation. For IFNG, a huge decrease was observed from 16 to 72 h post-ovulation. Finally, no significant differences were observed in the VEGF transcript. For the endometrium, the results showed a significant decline in the level of SCGB1A1 mRNA expression from 16 to 144 h post-ovulation induction. The highest levels of ITGA1 transcript were detected at 144 h, followed by the 16 h group and lower at 72 h post-ovulation. For IFNG there were no significant differences among post-ovulation induction times. Finally, it was possible to observe that VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but increased at 144 h. The functional significance of these observations may provide new insights into the maternal role in prenatal losses.

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Progesterone and the immunology of pregnancy

Cited by 255 publications

References 48 publications

Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17β-estradiol

Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17β-estradiol

Systemic Reduction of Functionally Suppressive CD4dimCD25highFoxp3+ Tregs in Human Second Trimester Pregnancy Is Induced by Progesterone and 17β-Estradiol

Oviductal and endometrial mRNA expression of implantation candidate biomarkers during early pregnancy in rabbit

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