Characteristics of p-Aminohippurate Transport in the Mammalian Kidney

Häberle, D. A.

doi:10.1007/978-3-642-68147-9_14

Cited by 13 publications

(1 citation statement)

References 136 publications

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“…PAH concentration in the tubule lumen exceeded that in the blood, suggesting that PAH secretion is an energy-requiring process (Grantham et al 1974;Häberle 1981). Based on experiments with rat renal basolateral membrane vesicles, we (Shimada et al 1987) and Pritchard (Pritchard 1988) proposed a model for energizing PAH uptake into proximal tubule cells.…”

Section: The Organic Anion Transportermentioning

confidence: 97%

Transport of organic anions across the basolateral membrane of proximal tubule cells

Burckhardt

2003

Reviews of Physiology, Biochemistry and Pharmacology

259

201

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Renal proximal tubules secrete diverse organic anions (OA) including widely prescribed anionic drugs. Here, we review the molecular properties of cloned transporters involved in uptake of OA from blood into proximal tubule cells and provide extensive lists of substrates handled by these transport systems. Where tested, transporters have been immunolocalized to the basolateral cell membrane. The sulfate anion transporter 1 (sat-1) cloned from human, rat and mouse, transported oxalate and sulfate. Drugs found earlier to interact with sulfate transport in vivo have not yet been tested with sat-1. The Na(+)-dicarboxylate cotransporter 3 (NaDC-3) was cloned from human, rat, mouse and flounder, and transported three Na(+) with one divalent di- or tricarboxylate, such as citric acid cycle intermediates and the heavy metal chelator 2,3-dimercaptosuccinate (succimer). The organic anion transporter 1 (OAT1) cloned from several species was shown to exchange extracellular OA against intracellular alpha-ketoglutarate. OAT1 translocated, e.g., anti-inflammatory drugs, antiviral drugs, beta-lactam antibiotics, loop diuretics, ochratoxin A, and p-aminohippurate. Several OA, including probenecid, inhibited OAT1. Human, rat and mouse OAT2 transported selected anti-inflammatory and antiviral drugs, methotrexate, ochratoxin A, and, with high affinities, prostaglandins E(2) and F(2alpha). OAT3 cloned from human, rat and mouse showed a substrate specificity overlapping with that of OAT1. In addition, OAT3 interacted with sulfated steroid hormones such as estrone-3-sulfate. The driving forces for OAT2 and OAT3, the relative contributions of all OA transporters to, and the impact of transporter regulation by protein kinases on renal drug excretion in vivo must be determined in future experiments.

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Section: The Organic Anion Transportermentioning

confidence: 97%

Transport of organic anions across the basolateral membrane of proximal tubule cells

Burckhardt

2003

Reviews of Physiology, Biochemistry and Pharmacology

259

201

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Principles of Electrolyte Transport Across Plasma Membranes of Renal Tubular Cells

Burckhardt

Greger

1992

Comprehensive Physiology

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The sections in this article are: Principles of Sodium Reabsorption Coupling of Sodium Transport to Bicarbonate Absorption Coupling of Sodium Reabsorption to Chloride Rheogenic Sodium Reabsorption Comparative Energetic Aspects Principles of Proton Secretion Sodium‐Dependent Proton Secretion Sodium‐Independent Proton Secretion Comparative Energetic Aspects Principles of Sodium‐Coupled Solute Absorption Specificity Source of Energy Homocellular Regulation Mechanisms Principles of Solute Uptake Across the Basolateral Membrane Anion Transport Systems in the Basolateral Membrane PAH Secretion: A Tertiary Active Process Conclusion

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Renal Excretion and Tubular Transport of Organic Anions and Cations

Roch-Ramel

Besseghir

Murer

1992

Comprehensive Physiology

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The sections in this article are: Organic Anions Introduction Renal Excretion and Tubular Transport of Organic Anions Mechanisms Involved in Tubular Transport of Organic Anions Conclusions on the Renal Transport of Organic Anions Organic Cations Introduction Renal Excretion and Tubular Transport of Organic Cations Mechanisms Involved in Tubular Transport of Organic Cations General Conclusions

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Characteristics of p-Aminohippurate Transport in the Mammalian Kidney

Cited by 13 publications

References 136 publications

Transport of organic anions across the basolateral membrane of proximal tubule cells

Transport of organic anions across the basolateral membrane of proximal tubule cells

Principles of Electrolyte Transport Across Plasma Membranes of Renal Tubular Cells

Renal Excretion and Tubular Transport of Organic Anions and Cations

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