Principles of Electrolyte Transport Across Plasma Membranes of Renal Tubular Cells

Abstract

The sections in this article are: Principles of Sodium Reabsorption Coupling of Sodium Transport to Bicarbonate Absorption Coupling of Sodium Reabsorption to Chloride Rheogenic Sodium Reabsorption Comparative Energetic Aspects Principles of Proton Secretion Sodium‐Dependent Proton Secretion Sodium‐Independent Proton Secretion Comparative Energetic Aspects Principles of Sodium‐Coupled Solute Absorption Specificity Source of Energy Homocellular Regulation Mechanisms Principles of Solute Uptake Across the Basolateral Membrane Anion Transport Systems in the Basolateral Membrane PAH Secretion: A Tertiary Active Process Conclusion

Analysis of energy metabolism and mechanism of loop diuretics in the thick ascending limb of Henle's loop in dog kidneys

“…This model was proposed by Hebert & Andreoli (1984). Minor modifications have been suggested by Hierholzer (1985) and Burckhardt & Greger (1992). The virtue of this model is that it greatly reduces the metabolic energy expenditure of NaCl transport in TALH.…”

Transport of organic anions in the liver. An update on bile acid, fatty acid, monocarboxylate, anionic amino acid, cholephilic organic anion, and anionic drug transport

“…Instead, a tertiary sodium-dependent CA uptake via indirect coupling with the sodium-dependent uptake of dicarboxylates, for example succinate and o~-ketoglutarate, was proposed (Zimmerli et al 1989b, Meier 1991. This uptake phenomenologically resembles a dicarboxylate/CA anion exchange as it was observed for organic anion uptake in the kidney (for references see Burckhardt and Greger 1992). In the kidney at the basolateral side of the cell membrane more than one organic anion carrier is operating: a sodium-dependent dicarboxylate carrier, a sulfate/organic anion exchange transporter, and a transport system for para-aminohippuric acid (PAH) with a broad substrate specificity for organic anions (Ullrich et al 1987;Ullrich and Rumrich 1988).…”

Protein kinase G activates inwardly rectifying K+channel in cultured human proximal tubule cells

“…IT IS GENERALLY ACCEPTED THAT the basolateral ATPregulated K ϩ channels in the proximal tubule are important for formation of the membrane potential that provides the driving force for electrogenic passive transport across the apical and basolateral membranes (2). Intracellular ATP is considered to act as a modulator coupling the function of these K ϩ channels to basolateral Na ϩ -K ϩ pump activity (1,8,29,33,34).…”