Characteristics of obese children with low content of arachidonic acid in plasma lipids

Okada, Tomoo; Sato, Noriko; Kuromori, Yuki; Miyashita, Michio; Tanigutchi, Kazuo; Iwata, Fujihiko; Hara, Mitsuhiko; Ayusawa, Mamoru; Harada, Kensuke; Saito, Emiko

doi:10.1111/j.1442-200x.2007.02394.x

Cited by 13 publications

(14 citation statements)

References 32 publications

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“…The DGLA content of common foods is very low. Hence, the increased DGLA status found in obese subjects cannot be explained by high dietary intake of DGLA; rather, it could be indicative of an enhanced conversion rate of LA, as proposed in other studies . In accordance with previous reports , we found significantly reduced indicators of Δ5 desaturase activity in overweight and obese subjects.…”

Section: Discussionsupporting

confidence: 92%

Long‐chain polyunsaturated fatty acid status in obesity: a systematic review and meta‐analysis

et al. 2015

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Long-chain polyunsaturated fatty acid (LCPUFA) status has recently been related to the pathogenesis of obesity. Our aims were to systematically review observational studies investigating LCPUFA status from different blood compartments in overweight or obese subjects and to assess the relationship between LCPUFA profile and obesity. The Ovid MEDLINE, Scopus and Cochrane Library CENTRAL databases were searched from inception to January 2014. The meta-analysis showed significant differences in the LCPUFA composition of total plasma lipids, plasma phospholipids and plasma cholesteryl esters between overweight or obese subjects and controls. Dihomo-γ-linolenic acid (DGLA) values were significantly higher in overweight or obese subjects compared with controls in all the investigated biomarkers. In addition, the DGLA/linoleic acid ratio (surrogate parameter for Δ6 desaturase activity) in plasma phospholipids was significantly elevated (mean difference [MD]: 0.05; 95% confidence interval [CI]: 0.02, 0.08; n = 280), while the arachidonic acid/DGLA ratio (surrogate parameter for Δ5 desaturase activity) was significantly decreased (MD: -0.55; 95% CI: -0.71, -0.39; n = 347) in overweight or obese subjects compared with controls. The results of the present meta-analysis confirm that LCPUFA profile is altered in obesity and suggest that the differences observed in desaturase activities may be responsible for the disturbed LCPUFA metabolism in obesity.

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Section: Discussionsupporting

confidence: 92%

Long‐chain polyunsaturated fatty acid status in obesity: a systematic review and meta‐analysis

et al. 2015

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“…Furthermore, weak but positive relationships were observed between the body fat percentage and log C20:3n-6 and log C20:4n-3. These results are similar to those obtained in obese children with a significantly elevated correlation between plasma C20:3n-6 and leptin 30) . These observations are supported by a report describing a negative correlation between C20:3n-6 and peripheral insulin sensitivity 31) , as well as high SCD and D6D activities and low D5D activity, generally considered to be associated with an insulin-resistant status 32,33) .…”

Section: Discussionsupporting

confidence: 81%

Differences in Serum Phospholipid Fatty Acid Compositions and Estimated Desaturase Activities between Japanese Men with and without Metabolic Syndrome

Maruyama

Yoneyama

Suyama

et al. 2008

JAT

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Aim: This study was designed to clarify differences in serum phospholipid fatty acid compositions and estimated desaturase activities between Japanese men with and without metabolic syndrome (MetS). Methods: From among 227 males, 40 to 59 years of age, excluding those receiving treatment for lipid disorders, 165 subjects (including 27 with MetS) were selected for this study. Serum phospholipid fatty acid compositions were determined, and desaturase activities were estimated. Results: The C15:0 and C17:0 fatty acids associated with hepatic function were lower, while the C20:3n-6 and C20:4n-3 fatty acids were higher, in subjects with than without MetS (p 0.05). The estimated desaturase activity for D5D(n-6) was lower in subjects with than without MetS (p 0.01). Body fat percentage was an independent negative predictor of C17:0, and a positive predictor of log C20:3n-6 and log C20:4n-3 (p 0.01). HDL-C was an independent negative predictor of log C15:0 and of C17:0 (p 0.01). Conclusion: Decreases in minor saturated fatty acids, accumulation of C20:3n-6 and C20:4n-3 and low estimated D5D activitiy were confirmed to be associated with MetS.

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“…This finding is accordingly in support of the literature data [28] and results of clinical research, where a considerable decrease of 18:2n-6 and 20:4n-6 FFA level in the plasma of children with obesity was shown [29]. The increase of 18:3n-6 and 20:3n-6 content -the precursors for 20:4n-6 synthesis, with simultaneous decrease of the product was found, suggesting the disturbance of 20:4n-6 biosynthesis under experimental IR.…”

Section: T a B L E 2 Content Of Total Lipids And Cholesterol Of Liposupporting

confidence: 81%

The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance

Onopchenko¹

2015

Ukr.Biochem.J.

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Characteristics of obese children with low content of arachidonic acid in plasma lipids

Cited by 13 publications

References 32 publications

Long‐chain polyunsaturated fatty acid status in obesity: a systematic review and meta‐analysis

Long‐chain polyunsaturated fatty acid status in obesity: a systematic review and meta‐analysis

Differences in Serum Phospholipid Fatty Acid Compositions and Estimated Desaturase Activities between Japanese Men with and without Metabolic Syndrome

The effect of N-stearoylethanolamine on plasma lipid composition in rats with experimental insulin resistance

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