Characteristics of never smoker lung cancer including environmental and occupational risk factors

Clément-Duchêne, Christelle; Vignaud, Jean-Michel; Stoufflet, Audrey; Bertrand, O.; Gislard, Antoine; Thiberville, Luc; Grosdidier, G.; Martinet, Yves; Bénichou, Jacques; Hainaut, Pierre; Paris, Christophe

doi:10.1016/j.lungcan.2009.04.005

Cited by 55 publications

(40 citation statements)

References 49 publications

(84 reference statements)

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“…Similar results have been found for exposure in the workplace and during childhood [4,5]. In a recent French study, we reported that 66% of LCINSs had been exposed to passive smoke, especially women and those exposed in domestic settings [6,7].…”

Section: Introductionsupporting

confidence: 86%

No impact of passive smoke on the somatic profile of lung cancers in never-smokers

Couraud¹,

Debieuvre²,

Moreau³

et al. 2015

Eur Respir J

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EGFR and HER2 mutations and ALK rearrangement are known to be related to lung cancer in never-smokers, while KRAS, BRAF and PIK3CA mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a "smoker-like" somatic profile compared with unexposed never-smokers.Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled.Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure (EGFR mutation: 46% in never exposed versus 41% in ever exposed; KRAS: 7% versus 7%; ALK: 13% versus 11%; HER2: 4% versus 5%; BRAF: 6% versus 5%; PIK3CA: 4% versus 2%). We observed a nonsignificant trend for a negative association between EGFR mutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers.There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer. @ERSpublications Never-smokers with lung cancer exposed to passive smoke do not have a smoker-like somatic mutation profile

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Section: Introductionsupporting

confidence: 86%

No impact of passive smoke on the somatic profile of lung cancers in never-smokers

Couraud¹,

Debieuvre²,

Moreau³

et al. 2015

Eur Respir J

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“…In fact, CLÉMENT-DUCHÊNE et al [18] have already shown, in 67 French never-smokers, that occupational exposure and passive smoking were differently distributed between the sexes. Indeed, some lung cancers are known to be related to domestic pollution exposure, although modestly, even in Europe [19].…”

Section: Discussionmentioning

confidence: 92%

BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers

et al. 2015

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Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood.All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences.384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35%versus8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference):EGFRin 51%,ALKin 8%,KRASin 6%,HER2in 3%,BRAFin 3%,PI3KCAin less than 1%, and multiple in 2%.We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).

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“…Il n'existe à ce jour pas d'explication rationnelle, mais probablement différentes causes comme par exemple un meilleur recueil de l'information du tabagisme, notamment depuis l'arrivée des inhibiteurs de l'epidermal growth factor receptor (EGFR), une espérance de vie qui augmente et donc une durée d'exposition au risque augmentée (d'où l'importance d'étudier l'incidence ajustée sur l'âge), d'un meilleur diagnostic de tumeurs auparavant éti-quetées carcinome de primitif inconnu. Les CBNPC des non-fumeurs diffèrent sur la clinique, les facteurs de risques associés et l'histologie du CBNPC du fumeur [4].…”

Section: Points Essentielsunclassified

Cancers bronchiques des non-fumeurs : particularités épidémiologiques, thérapeutiques et moléculaires

2011

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Characteristics of never smoker lung cancer including environmental and occupational risk factors

Cited by 55 publications

References 49 publications

No impact of passive smoke on the somatic profile of lung cancers in never-smokers

No impact of passive smoke on the somatic profile of lung cancers in never-smokers

BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers

Cancers bronchiques des non-fumeurs : particularités épidémiologiques, thérapeutiques et moléculaires

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