Characteristics of Lymphadenitis in Hospitalised Patients Bandar Lampung-Indonesia

Rusmini, Hetti; Ariza, Retno; Sari, Nur Rahayu Permana

doi:10.33024/minh.v2i1.1059

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…This is caused by increased activity and lack of personal sanitation at productive age so that the body's immune system is easily decreased and infected with Mycobacterium tuberculosis more quickly. 15,16 Lymphadenitis TB can be diagnosed based on the patient's clinical manifestations (fever, night sweats, weight loss) and supporting examinations, namely in the form of culture and PCR. The histopathological examination can reveal Langerhans giant cells, epitheloid cells, granulomatous inflammation, calcification, and caseous necrosis which is a form of illustration of the human body's immune response to pathogens.…”

Section: Discussionmentioning

confidence: 99%

Microscopic Features of Central Caseous Necrosis in Tuberculosis Lymphadenitis Patients: The Relationship with Lymphocyte Density

2023

bul.farmatera

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Tuberculosis lymphadenitis (TBLN) is the most common extra pulmonary TB (EPTB) case in the world with a range of 30-40% of all EPTB cases. When the body's immune system cannot kill the pathogen, the body will try to contain the pathogen (granuloma). The outer portion of the granuloma becomes calcified and the cells in the centre undergoes necrosis. The formation of central necrosis is associated with the emergence of cellular hypersensitivity with the features of local accumulation of macrophages and lymphocytes. The current study aimed to determine the relationship between the microscopic features of central caseous necrosis with lymphocyte density in patients with tuberculous lymphadenitis. Thirty histopathological slides of TBLN patients were observed under a microscope to see the features of central caseous necrosis and assess the lymphocyte density with the results assessed based on the cut-off point of the median of all lymphocyte mean values. Based on the microscopic examination, 25 samples of central caseous necrosis were found and the other 5 samples were not found to have caseous necrosis. Twenty-six patients had low lymphocyte density, and 4 patients had high lymphocyte density. The results of the Fisher Exact test obtained p = 0.009. There is a significant relationship between the features of central caseous necrosis and lymphocyte density in patients with TBLN.

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Section: Discussionmentioning

confidence: 99%

Microscopic Features of Central Caseous Necrosis in Tuberculosis Lymphadenitis Patients: The Relationship with Lymphocyte Density

2023

bul.farmatera

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“…7 Di negara endemis tuberkulosis seperti Indonesia, kebanyakan limfadenitis granulomatosa akan didiagnosis dan diterapi sebagai limfadenitis tuberkulosis. 9 Diagnosis banding lain seperti sarkoidosis, lepra, sinus histiosit, limfoma maligna, dll. masih dapat dipikirkan saat mendiagnosis limfoma grabulomatosa di daerah endemis tuberkulosis, sekalipun didapatkan gambaran khas epiteloid granuloma.…”

Section: Pendahuluanunclassified

Gambaran Klinis dan Histopatologis Pasien Limfadenopati Granulomatosa yang Berobat di Rumah Sakit Muhammadiyah Bandung

Widiyastuti,

Ismawati,

Rachmawati

2024

J Integr Kes Sains

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Limfadenopati granulomatosa memiliki beragam etiologi yang mendasarinya. Secara garis besar dapat diklasifikasikan karena infeksi dan non infeksi. Gambaran histopatologi limfadenitis granulomatosa membentuk struktur khusus seperti sel epiteloid disertai dengan sebukan sel radang, namun tidak spesifik. Limfadenitis tuberkulosis merupakan penyebab tersering limfadenopati di daerah endemis tuberkulosis seperti di Indonesia. Karakteristik klinis dan penunjang seperti pemeriksaan rontgen dapat membantu mendiagnosis penyakit yang mendasari lesi ini. Tujuan penelitian ini mengetahui gambaran klinis dan histopatologis limfadenitis granulomatosa di Rumah Sakit Muhammadiyah Bandung yang diharapkan dapat membantu mengarahkan diagnosis. Penelitian ini merupakan studi deskriptif kuantitatif yang diambil dari data rekam medis 40 pasien limfadenopati granulomatosa di Rumah Sakit Muhammadiyah Bandung periode Januari–Desember 2022. Hasil penelitian menunjukkan sebanyak 52% adalah perempuan, terbanyak di rentang usia 22–31 tahun (30%). Lesi terbanyak ditemukan di daerah leher kanan (35%) dengan gejala penyerta terbanyak adalah nyeri (20%). Hasil rontgen normal (23%) ditemukan lebih banyak dibanding dengan yang disertai kelainan. Karakteristik gambaran distribusi histopatologis paling banyak adalah sel radang limfosit (100%), histiosit (95%), dan sel epiteloid (92%), sedangkan paling sedikit adalah datia benda asing (20%). Limfadenitis tuberkulosis merupakan penyakit tersering yang mengakibatkan benjolan di leher dan menimbulkan gambaran histopatologi berupa granuloma yang beragam mulai dari granuloma bernekrosis, granuloma non nekrosis, dan granuloma supuratif. Pada penelitian ini didapatkan ketiga gambaran granuloma tersebut. Meskipun tempat penelitian ini di Indonesia merupakan endemi tuberkulosis, namun tetap perlu dipikirkan diagnosis banding lain yang harus disingkirkan sebelum menegakkan diagnosis yang tepat.AbstractGranulomatous limphadenopaty has various underlying etiologies. In general granulomatous lymphadenopathy can be classified as infectious and non-infectious. The histopathologic features of granulomatous lymphadenopathy creates a special structure with epitheloid cells surrounded by inflammatory cells, however these are not spesific. Tuberculous lymphadenitis is the frequent cause for lymphadenopathy in endemic area for tuberculosis as Indonesia. The clinical features and chest X-ray examination can be helpful for establishing the underlying diagnosis for the lesion. The aim of this research is to determine the clinical and histopathological features of granulomatous limphadenopaty at the Muhammadiyah Bandung Hospital for the period January–December 2022 which is expected to help in directing the diagnosis later. This study is a quantitative descriptional study from medical records of 40 patients with granulomatous lymphadenopathy admitted to Muhammadiyah Hospital in periode of January–December 2022. The results showed 52% patients were female, mostly in age group of 22–31 years old (30%). Most lesions located at right neck (35%), with pain as most frequent accompanied symptom (20%). Normal chest X-rays were more frequent than those with abnormal findings. The histopathologic features of the lesion showed the most histopathological distribution is lymphocyte inflammatory cells (100%), histiocytes (95%), and epithelioid cells (92%), while the least is foreign body datia (20%). Tuberculous lymphadenitis is the commonest etiology for diseases presenting with cervical adenopathy with histopatologic features of granuloma ranging from necrotizing, non necrotizing and suppurative granuloma. The three types of granulomas were found in this study. Despite that Indonesia the endemic area for tuberculosis, other differential diagnosis still needed to be eliminated before appropriate diagnosis can be made.

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“…Lymphadenopathy is a condition of enlarged lymph nodes with a size greater than 1 cm [1] [2]. The human body has about 500 to 600 lymph nodes, with the most being found in the axillae, groin, neck, chest, and abdomen.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Test Fine Needle Aspiration Biopsy (FNAB) Examination on Gold Standard Histopathological Tests for Identification of Colli Lymphadenopathy Patients at RSPAL. Dr. Ramelan Surabaya

Andhika¹,

Handayati²,

Woelansari³

2023

International Journal of Advanced Health Science and Technology

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Lymphadenopathy is a common clinical manifestation which requires rapid and accurate diagnosis. Fine Needle Aspiration Biopsy (FNAB) is used as an initial and direct diagnosis in cases of lymphadenopathy, confirmatory diagnosis of colli lymphadenopathy is carried out by histopathological examination. The purpose of this study was to determine the value of the FNAB diagnostic test for lymphadenopathy colli FNAB against the gold standard histopathology of Paraffin Blok for benign and malignant lymphadenopathy. This type of research is observational descriptive by taking medical record data (SIM-RS) of patients with lymphadenopathy in the colli region who were examined for FNAB and histopathology at the Anatomical Pathology Laboratory Installation, RSPAL dr. Ramelan Surabaya for the period January 2019 – March 2022. The sample used was selected using the total sampling method, obtained as many as 66 samples that met the inclusion criteria. The results of the FNAB examination were then matched against the histopathological gold standard examination data. Furthermore, the data was processed by 2x2 crosstabulation and diagnostic tests were carried out to determine the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy. The results showed that the accuracy of the FNAB diagnostic test was 86.56%, sensitivity 80.48%, specificity 96.15%, positive predictive value 97.05%, negative predictive value 75.75%. In general, it can be stated that the FNAB examination can be a screening diagnostic tool that is easy, fast, relatively affordable and applicable in helping to establish the diagnosis of colli lymphadenopathy.

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Characteristics of Lymphadenitis in Hospitalised Patients Bandar Lampung-Indonesia

Cited by 3 publications

References 3 publications

Microscopic Features of Central Caseous Necrosis in Tuberculosis Lymphadenitis Patients: The Relationship with Lymphocyte Density

Microscopic Features of Central Caseous Necrosis in Tuberculosis Lymphadenitis Patients: The Relationship with Lymphocyte Density

Gambaran Klinis dan Histopatologis Pasien Limfadenopati Granulomatosa yang Berobat di Rumah Sakit Muhammadiyah Bandung

Diagnostic Test Fine Needle Aspiration Biopsy (FNAB) Examination on Gold Standard Histopathological Tests for Identification of Colli Lymphadenopathy Patients at RSPAL. Dr. Ramelan Surabaya

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