Characteristics of lesional and extra-lesional cortical grey matter in relapsing–remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study

Yaldizli, Özgür; Pardini, Matteo; Sethi, Varun; Muhlert, Nils; Liu, Zheng; Tozer, Daniel J.; Samson, R; Wheeler‐Kingshott, Claudia A. M.; Yousry, Tarek; Miller, David H.; Chard, Declan

doi:10.1177/1352458515586085

Cited by 27 publications

(25 citation statements)

References 41 publications

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“…As cognitive impairment in MS is known to progress over 5-7 years (Deloire, Ruet, Hamel, Bonnet, & Brochet, 2010), it is possible that CLs influence cognitive function earlier than brain atrophy in patients with MS. (Geurts & Barkhof, 2008;Lucchinetti et al, 2011). Indeed, an MR-based study revealed both focal CLs and generalized GM abnormalities more frequently in SPMS than in RRMS (Yaldizli et al, 2016). Further, changes in extralesional GM were found to be more consistently associated with disability compared with CLs.…”

Section: Discussionmentioning

confidence: 96%

“…Like progressive MS, inflammatory cortical demyelination, consisting of microglial activation, neurodegeneration, and reduced oligodendrocytes, has also been observed early during the course of MS (Geurts & Barkhof, ; Lucchinetti et al., ). Indeed, an MR‐based study revealed both focal CLs and generalized GM abnormalities more frequently in SPMS than in RRMS (Yaldizli et al., ). Further, changes in extralesional GM were found to be more consistently associated with disability compared with CLs.…”

Section: Discussionmentioning

confidence: 99%

“…as CLs, subcortical WM lesions, and brain atrophy, differentially affect cognitive function in different types of MS (M. Calabrese et al, 2015;Rocca et al, 2015;Steenwijk et al, 2015;Yaldizli et al, 2016).…”

Section: However It Is Not Clear How Various Pathological Features mentioning

confidence: 99%

“…However, it is not clear how various pathological features, such as CLs, subcortical WM lesions, and brain atrophy, differentially affect cognitive function in different types of MS (M. Calabrese et al., ; Rocca et al., ; Steenwijk et al., ; Yaldizli et al., ). No study has comprehensively described the association between CLs, attention impairment, working memory deficits, and a decrease in EDSS score.…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study

et al. 2018

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IntroductionThis study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS).MethodsA total of 19 patients with MS were examined using double inversion recovery (DIR) sequences with 3T magnetic resonance imaging (MRI) and classified into two groups: CL and non‐CL. In‐house software was used to quantitatively determine the atrophy of each brain region. Activities of daily living (ADL) were estimated using the Kurtzke Expanded Disability Status Scale (EDSS). Cognitive function was assessed using the following tests: Mini‐Mental State Examination (MMSE), Trail Making Test (TMT), and Paced Auditory Serial Addition Task (PASAT). Z‐scores were used to assess significant differences in the neuropsychological test outcomes between the groups.ResultsSix of 19 patients had subcortical and deep WM lesions (non‐CL group; diagnosed with relapsing–remitting MS). Thirteen of 19 patients had both subcortical and cortical lesions (CL group; 9—relapsing–remitting MS; 4—primary/secondary progressive MS). There were no significant differences in age, education, and disease duration, but EDSS scores were significantly higher in the CL group compared to the non‐CL group. There were no significant differences in gray and white matter volume between the CL and the non‐CL groups, but the white matter lesion volume was significantly higher in the CL group compared to the non‐CL group. Neuropsychological tests showed significant performance worsening in the CL group as compared to the standard values for healthy individuals in their age group, especially in the TMT data.ConclusionsProgressive MS, which was associated with decreased physical functioning, ADL, and cognitive impairment, was found in patients in the CL group.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: However It Is Not Clear How Various Pathological Features mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study

et al. 2018

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“…Although these abnormalities occur early in the course of MS (Gallo et al, 2005), more marked DTI abnormalities in the NAWM occur in patients with more significant disability and progressive forms of MS (Preziosa et al, 2011). DTI is also sensitive for the detection of microstructural changes in cortical gray matter (GM), again both in lesions and in normal-appearing tissue, associated with physical disability and cognitive impairment in MS (Yaldizli et al, 2016;Roman and Arnett, 2016). Combined MRI-histopathological studies have demonstrated high correlations between changes in DTI indices and myelin content/axonal count in NAWM and WM lesions, suggesting that DTI abnormalities reflect pathological changes relevant to disability and disease progression in MS (Kim et al, 2006;Schmierer et al, 2007;Budde et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Sensitivity of multi-shell NODDI to multiple sclerosis white matter changes: a pilot study

Schneider¹,

Brownlee²,

Zhang³

et al. 2017

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SummaryDiffusion tensor imaging (DTI) is sensitive to white matter (WM) damage in multiple sclerosis (MS), not only in focal lesions but also in the normal-appearing WM (NAWM). However, DTI indices can also be affected by natural spatial variation in WM, as seen in crossing and dispersing white matter fibers. Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion-weighted imaging technique that provides distinct indices of fiber density and dispersion. We performed NODDI of lesion tissue and NAWM in five MS patients and five controls, comparing the technique with traditional DTI. Both DTI and NODDI identified tissue damage in NAWM and in lesions. NODDI was able to detect additional changes and it provided better contrast in MS-NAWM microstructure, because it distinguished orientation dispersion and fiber density better than DTI. We showed that NODDI is viable in MS patients and that it offers, compared with DTI parameters, improved sensitivity and possibly greater specificity to microstructure features such as neurite orientation.

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Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis

Gracien

Jurcoane

Wagner

et al. 2016

J. Magn. Reson. Imaging

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Characteristics of lesional and extra-lesional cortical grey matter in relapsing–remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study

Abstract: Background: In multiple sclerosis(MS), diffusion tensor and

Cited by 27 publications

References 41 publications

Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study

Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study

Sensitivity of multi-shell NODDI to multiple sclerosis white matter changes: a pilot study

Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis

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