Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis

Abstract

Out of the parameters studied, cortical T is best suited to detect cortical damage as an imaging surrogate of clinical disability in RRMS. J. Magn. Reson. Imaging 2016;44:1600-1607.

Longitudinal quantitative MRI assessment of cortical damage in multiple sclerosis: A pilot study

“…In the cortex, a region of interest (ROI) analysis showed that cortical T 1 prolongation and PD increase are present in early MS, indicating cortical damage . A separate study confirmed a relationship between cortical T 1 and the degree of disability in a relapsing‐remitting MS (RRMS) patient group, covering a range of disability severity and disease duration . Cortical demyelination at early MS stages can also be assessed with T 2 relaxometry, providing an alternative to the technically challenging T 1 and PD mapping …”

“…These patients were scored on the Expanded Disability Status Scale (EDSS) before the first scan . The patient pool comprised participants who had previously been included in cross‐sectional analyses, and we also used data obtained from a previous study into white matter …”

“…These patients were scored on the Expanded Disability Status Scale (EDSS) before the first scan. 14 The patient pool comprised participants who had previously been included in cross-sectional analyses, [5][6][7]15 and we also used data obtained from a previous study into white matter. 4 Written informed consent was given, and this study was approved by the Ethics Committee of the State Medical Association of Rhineland-Palatine.…”

“…5 A separate study confirmed a relationship between cortical T 1 and the degree of disability in a relapsingremitting MS (RRMS) patient group, covering a range of disability severity and disease duration. 6 Cortical demyelination at early MS stages can also be assessed with T 2 relaxometry, providing an alternative to the technically challenging T 1 and PD mapping. 7 Several previous approaches using qMRI techniques to assess longitudinal changes in tissue microarchitecture were undertaken, but yielded conflicting results:…”

Parameter map error due to normal noise and aliasing artifacts in MR fingerprinting

“…MRI has long been used as a diagnostic tool, taking advantage of the MR signal’s dependence on underlying tissue properties, such as relaxation times and spin density, to provide natural contrast between tissue types. While many MR experiments are designed to provide qualitative weighting for a particular property, quantitative mapping is a useful diagnostic tool, for example, in oncology, cardiology, and neurology …”