BACKGROUND: Headache is a very challenging condition to treat. We are presenting a unique approach for treating headache and occipital neuralgia that involves placing a wireless peripheral nerve stimulation system at the C2 and C3 levels. CASE REPORT: A 39-year-old man with a history of headache and occipital neuralgia resistant to several treatment modalities was treated with occipital nerve stimulation at the levels of C2 and C3. CONCLUSION: Peripheral nerve stimulation at the C2 and C3 levels is a unique approach for treating resistant headache and occipital neuralgia. KEY WORDS: C2, C3, headache, occipital neuralgia, peripheral nerve stimulation