Characteristics of Hydrolysis Resistant Polycaprolactone/Palm Kernel Oil Based Polyol

Zain, Norazwani Muhammad; Ahmad, Sahrim; Ali, Ernie Suzana; Zubir, Syazana Ahmad; Ahad, Nor Azwin

doi:10.4028/www.scientific.net/amr.576.334

Cited by 10 publications

(8 citation statements)

References 8 publications

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“…58 , 59 The small peak at 1294 cm −1 was pertained to C-O and C-C stretching bonds in the PCL crystalline phase. 57 A sharp peak at a wavelength of 1235.18 cm −1 can be attributed to the C-O stretching bond both in HA and PCL. It was also possible that this peak was related to the vibration of the amide III group in the gelatin structure.…”

Section: Resultsmentioning

confidence: 99%

“…This peak was displaced to higher wavelengths from the original peak in the pure PCL absorption spectrum, which can be related to PCL interaction with the nanocomposite core of the scaffold. 56 , 57…”

Section: Resultsmentioning

confidence: 99%

“…27 A sharp peak at 705.819 cm −1 can be attributed to the C-H stretching bond in atorvastatin or PCL. 57…”

Section: Resultsmentioning

confidence: 99%

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Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering

et al. 2020

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In this study, gelatin/hyaluronic acid (HA) scaffolds containing different amounts of atorvastatin-loaded nanostructured lipid carriers (NLCs) coated entirely with polycaprolactone (PCL) film were fabricated for skin regeneration. 12 atorvastatin-loaded NLCs formulations were synthesized, and particle size, zeta potential, drug entrapment efficiency (EE), and drug release of the formulations were determined. The optimum freeze-dried atorvastatin-loaded NLCs were added in 3 different weight percentages to the gelatin and HA membranous scaffolds. Thereafter, the membranes were coated entirely by a thin layer of the PCL. They were characterized, and then mechanical properties, in vitro degradation and in vitro drug release were assessed. Moreover, human dermal fibroblasts (HDF) were cultured on the prepared nanocomposite scaffolds in order to investigate the cytotoxicity by the MTT assay after the first day, third day, and fifth day. Results revealed that the most favorable atorvastatin-loaded NLCs had 99.54 nm average particle size, −24.30 mV zeta potential, 97.98% EE, and 75.24% drug release within 237 hrs. Mechanical tests indicated that all the three scaffolds had approximately a 90 MPa elastic modulus which was more than two-fold of tensile modulus of normal human skin. The in vitro degradation test demonstrated that the membranes were degraded up to 98% after 5 days, and the scaffolds drug release efficiency (DRE) was in a range of 75–79% during those 5 days. The MTT assay results confirmed the cytocompatibility of the scaffolds. The scaffold containing 54.1 wt% NCLs was the optimum sample (S3). Scanning Electron Microscopy (SEM) images of the latter one showed the uniform distribution of the NLCs with an average size of 150 nm, and the images of cultured HDF illustrated the good cell attachment. In conclusion, suitable physicochemical and biological properties of the novel gelatin/HA/PCL nanocomposite scaffold containing 54.1 wt% atorvastatin-loaded NLCs (S3) can be a good candidate for skin regeneration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering

et al. 2020

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“…The spectrum also showed two bands at 2944–2867 cm −1 , representing symmetric and asymmetric CH 2 stretching, respectively. The band observed at 732 cm −1 was assigned to the CH 2 rocking vibration of PCL, which indicates a linear chain aliphatic PCL structure [ 75 , 76 , 77 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of ABA-Type Triblock Copolymers Using Novel Bifunctional PS, PMMA, and PCL Macroinitiators Bearing p-xylene-bis(2-mercaptoethyloxy) Core

Mısır,

Savaskan Yılmaz,

Bilgin

2023

Polymers

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Syntheses of novel bifunctional poly(methyl methacrylate) (PMMA)-, poly(styrene) (PS)-, and (poly ε-caprolactone) (PCL)-based atom transfer radical polymerization (ATRP) macroinitiators derived from p-xylene-bis(1-hydroxy-3-thia-propanoloxy) core were carried out to obtain ABA-type block copolymers. Firstly, a novel bifunctional ATRP initiator, 1,4-phenylenebis(methylene-thioethane-2,1-diyl)bis(2-bromo-2-methylpropanoat) (PXTBR), synthesized the reaction of p-xylene-bis(1-hydroxy-3-thia-propane) (PXTOH) with α-bromoisobutryl bromide. The PMMA and PS macroinitiators were prepared by ATRP of methyl methacrylate (MMA) and styrene (S) as monomers using (PXTBR) as the initiator and copper(I) bromide/N,N,N′,N″,N″-pentamethyldiethylenetriamine (CuBr/PMDETA) as a catalyst system. Secondly, di(α-bromoester) end-functionalized PCL–based ATRP macronitiator (PXTPCLBr) was prepared by esterification of hydroxyl end groups of PCL-diol (PXTPCLOH) synthesized by Sn(Oct)2–catalyzed ring opening polymerization (ROP) of ε-CL in bulk using (PXTOH) as initiator. Finally, ABA-type block copolymers, PXT(PS-b-PMMA-b-PS), PXT(PMMA-b-PS-b-PMMA), PXT(PS-b-PCL-b-PS), and PXT(PMMA-b-PCL-b-PMMA), were synthesized by ATRP of MMA and S as monomers using PMMA-, PS-, and PCL-based macroinitiators in the presence of CuBr/PMDETA as the catalyst system in toluene or N,N-dimethylformamide (DMF) at different temperatures. In addition, the extraction abilities of PCL and PS were investigated under liquid–liquid phase conditions using heavy metal picrates (Ag+, Cd2+, Cu2+, Hg2+, Pb2+, and Zn2+) as substrates and measuring with UV-Vis the amounts of picrate in the 1,2–dichloroethane phase before and after treatment with the polymers. The extraction affinity of PXTPCL and PXTPS for Hg2+ was found to be highest in the liquid–liquid phase extraction experiments. Characterizations of the molecular structures for synthesized novel initiators, macroinitiators, and the block copolymers were made by spectroscopic (FT–IR, ESI–MS, 1H NMR, 13C NMR), DSC, TGA, chromatographic (GPC), and morphologic SEM.

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“…Figures 8 and 9 show the FT-IR spectra of the RT27 CSS-PCM before and after 500 thermal cycles. The main bands detected related to PCL are the C-H bonds in the -CH2 stretching bands (2943-2866 cm −1 ), the -C=O stretching band (1722 cm −1 ), the -C-H bond in -CH2 bending bands (1470-1460 cm −1 ), the C-O and C-C stretching bands (1293 cm −1 ), the C-O-C stretching bands (1239-1164 cm −1 ), the OC-O stretching (1190 cm −1 ), the C-O stretching band, corresponding to the ester group vibration, (1108 cm −1 ) and -CH2 rocking bands (760-700 cm −1 ) [25][26][27]. The main bands detected related to RT27 paraffin content are the alkyl stretching bands (2956, 2920, and 2851 cm −1 ) [28].…”

Section: Rt27/pclmentioning

confidence: 99%

Novel Shape-Stabilized Phase Change Material with Cascade Character: Synthesis, Performance and Shaping Evaluation

et al. 2021

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Thermal Energy Storage (TES) materials, such as Phase Change Materials (PCMs) are proven to enhance the energy efficiency in many fields, such as automotive and building sectors, which correspond to the most energy intensive ones. Shape-stabilized PCM and cascade PCM are procedures to overcome the most important barriers when PCMs are applied since PCMs need to be encapsulated for their technical use: the leakage of the liquid phase, corrosion, low heat transfer and narrow temperature of application. In the present study, a novel shape stabilized PCM with cascade performance (cascade shape stabilized phase change material, CSS-PCM) is synthesized via dissolution, which allows up to 60 wt.% of a paraffin-PCM in the final composition. The novel CSS-PCM is based on a biopolymer, the polycaprolactone (PCL), a low melting temperature polyester as polymeric matrix and RT27 and Micronal DS 5040 acting as PCM. To evaluate the performance of the new TES materials developed, several techniques have been used: Differential Scanning Calorimetry (DSC), and Fourier-Transformed Infrared (FT-IR) spectroscopy were used to evaluate the thermophysical properties and the chemical properties of the different formulations. The CSS-PCM show an increment of storage capacity by increasing the PCM content, and the thermal reliability was also tested: some of the CSS-PCM formulations were stable for up to 500 thermal cycles. Finally, as a potential application of the new polymeric-based PCM 3D, a printing attempt was performed in order to analyze the viability of the formulations to be used as 3D printing material as a first proof of concept.

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Characteristics of Hydrolysis Resistant Polycaprolactone/Palm Kernel Oil Based Polyol

Cited by 10 publications

References 8 publications

Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering

Pharmaceutical evaluation of atorvastatin-loaded nanostructured lipid carriers incorporated into the gelatin/hyaluronic acid/polycaprolactone scaffold for the skin tissue engineering

Synthesis and Characterization of ABA-Type Triblock Copolymers Using Novel Bifunctional PS, PMMA, and PCL Macroinitiators Bearing p-xylene-bis(2-mercaptoethyloxy) Core

Novel Shape-Stabilized Phase Change Material with Cascade Character: Synthesis, Performance and Shaping Evaluation

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