Characteristics of Hepatitis C in Renal Transplant Candidates

Cotler, Scott J.; Diaz, Gloria; Gundlapalli, Sushama; Jakate, S.; Chawla, Anshuman; Mital, Deepak; Jensik, S.; Jensen, Donald M.

doi:10.1097/00004836-200208000-00013

Cited by 87 publications

(65 citation statements)

References 21 publications

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“…These findings were similar to those reported by other authors that studied patients with ESRD (9,(13)(14)(15).…”

Section: Discussionsupporting

confidence: 92%

“…The lower degree of inflammatory activity and liver fibrosis in our HD patients is similar to findings described by other groups (9,12,13,15). We did not observe any association between inflammation and duration of HD treatment, although Sezer et al (14) have reported that the longer the time on HD, the lower the degree of liver inflammation.…”

Section: Discussionsupporting

confidence: 91%

“…Similarly to other studies, we found that HD patients had significantly lower ALT levels than patients with normal renal function (9,14). Univariate analysis of data from patients with elevated ALT levels showed more frequent severe inflammatory activity (P ϭ 0.017), but significance was not found in the multivariate analysis (P ϭ 0.679).…”

Section: Discussionsupporting

confidence: 85%

“…Barril (8) reported that progression time to cirrhosis can be much shorter in HCV-infected HD patients than in patients with normal renal function. However, other studies suggest that HCV-infected HD patients present a lower degree of inflammatory activity and a lower stage of liver fibrosis compared with HCV-infected patients with normal renal function (9,12,15). Indeed, the effects of chronic uremia and HD on HCV-related liver disease and on the progression of liver fibrosis in HCV-infected patients with ESRD remain unknown.…”

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confidence: 99%

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Hepatitis C Is Less Aggressive in Hemodialysis Patients than in Nonuremic Patients

Trevizoli

Menezes²,

Velasco³

et al. 2008

Clinical Journal of the American Society of Nephrology

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Background and objectives: The severity of liver disease among hepatitis C patients on hemodialysis is controversial. The aim of this study was to compare the clinical, biochemical, and liver histologic characteristics of hepatitis C virus (HCV) in hemodialysis patients and in those with normal renal function.Design, setting, participants, & measurements: A case-control study was carried out with 36 HCV patients on hemodialysis and 37 HCV patients with normal renal function matched for gender, age at infection, and estimated time of infection.Results: HCV patients on hemodialysis had lower levels of alanina aminotransferase and lower viral load. Hepatic fibrosis was significantly higher in the patients with normal renal function (73%) than in hemodialysis patients (47.2%, P < 0.025); the same was observed for inflammatory activity (control group 59.5% versus hemodialysis patients 27.7%, P ‫؍‬ 0.003). In addition, the risk of tissue inflammation was four times lower in hemodialysis patients (odds ratio ‫؍‬ 0.23, P < 0.004), and severe inflammatory activity on biopsy was the only independent risk factor for fibrosis (P < 0.001).Conclusions: The lower biochemical and inflammatory activities observed in hemodialysis patients suggest that hemodialysis and uremia may have a protective role against progression of the disease caused by HCV.

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“…These findings were similar to those reported by other authors that studied patients with ESRD (9,(13)(14)(15).…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

See 2 more Smart Citations

Hepatitis C Is Less Aggressive in Hemodialysis Patients than in Nonuremic Patients

Trevizoli

Menezes²,

Velasco³

et al. 2008

Clinical Journal of the American Society of Nephrology

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“…Recent studies have focused on using simple biochemical indices to predict the severity of hepatic fibrosis in uremic and nonuremic patients with CHC, and the aspartate aminotransferase (AST)-to-platelet ratio index (APRI) was considered useful (17,(23)(24)(25)(26)(27)(28). Nevertheless, studies for hemodialysis patients showed that the major strength of APRI was to exclude significant hepatic fibrosis, and only 50% patients could be correctly diagnosed (27,28).…”

Section: Introductionmentioning

confidence: 99%

Transient Elastography to Assess Hepatic Fibrosis in Hemodialysis Chronic Hepatitis C Patients

Liu¹,

Liang²,

Huang³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Although percutaneous liver biopsy (PLB) is the gold standard for staging hepatic fibrosis in hemodialysis patients with chronic hepatitis C (CHC) before renal transplantation or antiviral therapy, concerns exist about serious postbiopsy complications. Using transient elastography (TE, Fibroscan) to predict the severity of hepatic fibrosis has not been prospectively evaluated in these patients.Design, setting, participants, & measurements A total of 284 hemodialysis patients with CHC were enrolled. TE and aspartate aminotransferase-to-platelet ratio index (APRI) were performed before PLB. The severity of hepatic fibrosis was staged by METAVIR scores ranging from F0 to F4. Receiver operating characteristic curves were used to assess the diagnostic accuracy of TE and APRI, taking PLB as the reference standard. ResultsThe areas under curves of TE were higher than those of APRI in predicting patients with significant hepatic fibrosis (ՆF2) (0.96 versus 0.84, P Ͻ 0.001), those with advanced hepatic fibrosis (ՆF3) (0.98 versus 0.93, P ϭ 0.04), and those with cirrhosis (F4) (0.99 versus 0.92, P ϭ 0.13). Choosing optimized liver stiffness measurements of 5.3, 8.3, and 9.2 kPa had high sensitivity (93-100%) and specificity (88 -99%), and 87, 97, and 93% of the patients with a fibrosis stage of ՆF2, ՆF3, and F4 were correctly diagnosed without PLB, respectively.Conclusions TE is superior to APRI in assessing the severity of hepatic fibrosis and can substantially decrease the need of staging PLB in hemodialysis patients with CHC.

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Vortex motion‐based particle swarm optimisation for energy consumption of alumina evaporation

Zhu¹,

Chai²,

Yang³

et al. 2012

Can J Chem Eng

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The aim of the alumina evaporation process is to improve the concentration of sodium aluminate solution by evaporating the excess water contained in the solution. The evaporation is achieved using heat from steam. Since steam consumption is the major operating costs, in this paper, we investigate an operation optimisation problem for the evaporation process to minimise steam consumption subject to a constraint on the particular quality of the final sodium aluminate solution. This paper proposes a new particle swarm optimisation (PSO) algorithm based on vortex motion to solve this optimisation problem. We demonstrate the effectiveness of the PSO algorithm on benchmark functions. We then apply it to a real industrial evaporation process, where the optimal results show that the steam consumption is considerably reduced. © 2012 Canadian Society for Chemical Engineering

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Characteristics of Hepatitis C in Renal Transplant Candidates

Cited by 87 publications

References 21 publications

Hepatitis C Is Less Aggressive in Hemodialysis Patients than in Nonuremic Patients

Hepatitis C Is Less Aggressive in Hemodialysis Patients than in Nonuremic Patients

Transient Elastography to Assess Hepatic Fibrosis in Hemodialysis Chronic Hepatitis C Patients

Vortex motion‐based particle swarm optimisation for energy consumption of alumina evaporation

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