Characteristics of follicular fluid in ovaries with endometriomas

Giacomini, Elisa; Sánchez, Ana M.; Sarais, Veronica; Beitawi, Soha Al; Candiani, Massimo; Viganò, Paola

doi:10.1016/j.ejogrb.2016.01.032

Cited by 27 publications

(21 citation statements)

References 48 publications

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“…As oocyte quality is well reflected by the ability to complete maturation and undergo successful fertilization, the best clinical markers of oocyte competence are represented by number of MII (mature) oocytes retrieved and fertilization rates observed in IVF/ICSI outcomes. The hitherto published available evidence seems to suggest that a reduction in the number of mature oocytes retrieved is consistently associated with endometriosis, compared to other causes of infertility [22, 65–67, 74], while a reduction in fertilization rates is likely to be associated more with minimal/mild rather than with moderate/severe endometriosis [62, 72, 73]. …”

Section: Discussionmentioning

confidence: 99%

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Is the oocyte quality affected by endometriosis? A review of the literature

et al. 2017

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Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period causing infertility and pelvic pain. The disease, especially at the ovarian site has been shown to have a detrimental impact on ovarian physiology. Indeed, sonographic and histologic data tend to support the idea that ovarian follicles of endometriosis patients are decreased in number and more atretic. Moreover, the local intrafollicular environment of patients affected is characterized by alterations of the granulosa cell compartment including reduced P450 aromatase expression and increased intracellular reactive oxygen species generation. However, no comprehensive evaluation of the literature addressing the effect of endometriosis on oocyte quality from both a clinical and a biological perspective has so far been conducted. Based on this systematic review of the literature, oocytes retrieved from women affected by endometriosis are more likely to fail in vitro maturation and to show altered morphology and lower cytoplasmic mitochondrial content compared to women with other causes of infertility. Results from meta-analyses addressing IVF outcomes in women affected would indicate that a reduction in the number of mature oocytes retrieved is associated with endometriosis while a reduction in fertilization rates is more likely to be associated with minimal/mild rather than with moderate/severe disease. However, evidence in this field is still far to be conclusive, especially with regards to the effects of different stages of the disease and to the impact of patients’ previous medical/surgical treatment(s).

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Section: Discussionmentioning

confidence: 99%

“…A large number of studies have been published describing how endometriosis may alter various factors presented in the FF [16, 22–24]. The stage of the disease based on the revised classification established by the American Society for Reproductive Medicine (ASRM) [25] may have a strong importance in this context [26].…”

Section: Introductionmentioning

confidence: 99%

Is the oocyte quality affected by endometriosis? A review of the literature

et al. 2017

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“…Free iron is a strong oxidant and, when present at high levels, contributes to the production of ROS [37][38][39][40][41]. A fine-tuned regulation of lethal and sublethal oxidative stress responses might modulate either cell death or tumor initiation, respectively, due to the iron-induced DNA damage, mutations, and genomic instability.…”

Section: Molecular and Genetic Outline Of Endometriosis-associated Ovmentioning

confidence: 99%

Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated?

Vercellini

Viganò

Buggio

et al. 2018

Best Practice & Research Clinical Obstetrics & Gynaecol

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In women with endometriosis, the lifetime risk of ovarian cancer is increased from 1.4% to about 1.9%. The risk of clear cell and endometrioid ovarian cancer is, respectively, tripled and doubled. Atypical endometriosis, observed in 1-3% of endometriomas excised in premenopausal women, is the intermediate precursor lesion linking typical endometriosis and clear cell/endometrioid tumors. Prolonged oral contraceptive use is associated with a major reduction in ovarian cancer risk among women with endometriosis. Surveillance ± progestogen treatment or surgery should be discussed in perimenopausal women with small, typical endometriomas. In most perimenopausal women with a history of endometriosis but without endometriomas, surveillance instead of risk-reducing bilateral salpingo-oophorectomy seems advisable. Risk-reducing salpingo-oophorectomy might benefit patients at particularly increased risk, but the evidence is inconclusive. Risk profiling models and decision aids may assist patients in their choice. Screening of the general perimenopausal population to detect asymptomatic endometriomas is unlikely to reduce disease-specific mortality.

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“…В нескольких исследованиях показано, что эндометриоз яичников и других участков тазовой области может отрицательно влиять на стероидогенез гранулезных клеток (ГК) яичников, уменьшая экспрессию ароматазы P450, являющейся ключевым ферментом синтеза эстрогенов, согласно теории двух клеток, и выработку 17β-эстрадиола (E 2 ) [10,23]. Эстрадиол, в свою очередь, имеет решающее значение для развития фолликулов и образования компетентного ооцита, способного достичь стадии МII и оплодотвориться [7].…”

Section: Endometriosis and Oocytes (A Review)unclassified

“…Кроме того, отмечено влияние эндометриоза на опосредованное железом окислительное повреждение фолликулов, так как в ФЖ фолликулов, развивающихся рядом с эндометриоидной кистой, отмечаются более высокие показатели уровня железа по сравнению с ФЖ фолликулов интактных яичников [9,10,17].…”

Section: Endometriosis and Oocytes (A Review)unclassified

Endometriosis and oocytes (a review)

Trubitsyna¹,

Асатурова²,

Adamyan³

2018

Probl. reprod.

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Objective-to present the systematic analysis of the data of modern literature on the effect of endometriosis on oocytes and markers of their quality. Material and methods. The review contains data from foreign studies presented in the electronic database of Pubmed for the last 3 years. Results. Analysis of literature data showed that endometriosis adversely affects the quality of the oocyte and negatively correlates with the potential for the embryo development. Conclusion. Infertility of patients with endometriosis is associated with a decrease in the quality of oocytes, rather than with an endometrial medium or susceptibility. However, the observations are still controversial and require more careful consideration of disputed points and a deeper analysis.

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Characteristics of follicular fluid in ovaries with endometriomas

Cited by 27 publications

References 48 publications

Is the oocyte quality affected by endometriosis? A review of the literature

Is the oocyte quality affected by endometriosis? A review of the literature

Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated?

Endometriosis and oocytes (a review)

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