Characteristics of Epstein-Barr virus associated childhood non-Hodgkin’s lymphoma in the Republic of Korea

Kim, Dong-Hoon; Ko, Young‐Hyeh; Suh, Yeon‐Lim; Koo, Hong-Hoe; Huh, Jooryung; Lee, Won-Keun

doi:10.1007/s00428-005-1277-4

Cited by 13 publications

(16 citation statements)

References 15 publications

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“…ALCL has been reported as positive for EBER in situ hybridization in 0% to 23% of cases in several studies [5,7,9,36,40,42]. However, none of the 13 cases of ALCL were positive in the present study, although 2 cases presented EBER expression that was limited to rare non-neoplastic lymphoid cells.…”

Section: Ptcl Nos -Peripheral T-cell Lymphoma Not Otherwise Specificontrasting

confidence: 63%

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Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Karaarslan¹,

Hekımgıl²,

Soydan³

et al. 2015

pjp

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Various racial and geographic differences have been observed in studies questioning the role of Epstein-Barr virus (EBV) infection in the etiology of T-and NK-cell lymphomas. The aim of this study was to evaluate the relationship of EBV with nodal or extranodal (skin excluded) T-and NK-cell lymphoma subtypes encountered in our geographic area. Sixty-two cases of peripheral T-cell lymphoma were included in the study. EBV-encoded early RNA (EBER) was detected by in situ hybridization. The distributions of T-and NK-cell lymphoma subtypes were as follows: 32 peripheral T-cell lymphomas, unspecified (PTCL, NOS), 13 anaplastic large-cell lymphomas (ALCL), 8 angioimmunoblastic T-cell lymphomas (AIT-CL), 4 extranodal NK/T-cell lymphomas, nasal type (NKTCL), 3 enteropathy-type T-cell lymphomas (ETTCL), 1 hepatosplenic T-cell lymphoma (HSTCL), and 1 subcutaneous panniculitis-like T-cell lymphoma (SPTCL). Using a cut-off value of > 25% of EBER-positive neoplastic lymphoid cells, EBV was positive in 22.6% of all cases. According to subtype, the neoplastic cells of 31.3% of PTCL, NOS and 100% of extranodal NKTCL, nasal type were EBER positive, whereas some cases of ALCL, AITCL, and ETTCL presented EBER-positive non-neoplastic cells, and all cells of HSTCL and SPTCL were EBV negative. Extranodal NKTCL, nasal type, presented the strongest association with EBV, followed by PTCL, NOS.

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Section: Ptcl Nos -Peripheral T-cell Lymphoma Not Otherwise Specificontrasting

confidence: 63%

“…EBER-positive staining was found in 31.3% of cases in the heterogeneous PTCL, NOS group, while this group has been reported to exhibit 18-68% positivity in other studies [5,7,9,41,42].…”

Section: Ptcl Nos -Peripheral T-cell Lymphoma Not Otherwise Specifimentioning

confidence: 60%

Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Karaarslan¹,

Hekımgıl²,

Soydan³

et al. 2015

pjp

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“…In paediatric patients, studies have reported an association between EBV and NHL in 21-25% of cases [24,25] and even 100% in children with primary and acquired immunodeficiency [26]. Moreover, 95% of endemic BL have been reported to be EBV positive compared to 15 to 20% of the sporadic BL cases [4,7,8].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Non-Hodgkin’s lymphoma and blood levels of Epstein-Barr Virus in children in north-western Tanzania: a case control study

et al. 2013

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BackgroundNon-Hodgkin’s Lymphomas (NHL) are common in African children, with endemic Burkitt’s lymphoma (BL) being the most common subtype. While the role of Epstein-Barr Virus (EBV) in endemic BL is known, no data are available about clinical presentations of NHL subtypes and their relationship to Human Immunodeficiency Virus (HIV) infection and Epstein Barr Virus (EBV) load in peripheral blood of children in north-western, Tanzania.MethodsA matched case control study of NHL subtypes was performed in children under 15 years of age and their respective controls admitted to Bugando Medical Centre, Sengerema and Shirati district designated hospitals in north-western, Tanzania, between September 2010 and April 2011. Peripheral blood samples were collected on Whatman 903 filter papers and EBV DNA levels were estimated by multiplex real-time PCR. Clinical and laboratory data were collected using a structured data collection tool and analysed using chi-square, Fisher and Wilcoxon rank sum tests where appropriate. The association between NHL and detection of EBV in peripheral blood was assessed using conditional logistic regression model and presented as odds ratios (OR) and 95% confidence intervals (CI).ResultsA total of 35 NHL cases and 70 controls matched for age and sex were enrolled. Of NHLs, 32 had BL with equal distribution between jaw and abdominal tumour, 2 had large B cell lymphoma (DLBCL) and 1 had NHL-not otherwise specified (NHL-NOS). Central nervous system (CNS) presentation occurred only in 1 BL patient; 19 NHLs had stage I and II of disease. Only 1 NHL was found to be HIV-seropositive. Twenty-one of 35 (60%) NHL and 21 of 70 (30%) controls had detectable EBV in peripheral blood (OR = 4.77, 95% CI 1.71 – 13.33, p = 0.003). In addition, levels of EBV in blood were significantly higher in NHL cases than in controls (p = 0.024).ConclusionsBL is the most common childhood NHL subtype in north-western Tanzania. NHLs are not associated with HIV infection, but are strongly associated with EBV load in peripheral blood. The findings suggest that high levels of EBV in blood might have diagnostic and prognostic relevance in African children.

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“…Simian T‐cell leukemia virus has been detected in simian T‐cell lymphoma, and it has been suggested that the viral infection may be oncogenic . Although EBV is found in 98% of endemic Burkitt lymphoma , a relationship between EBV and NHL has been identified in 20–25% of sporadic cases . An EBV association with nodal peripheral T‐cell lymphomas has been reported in angioimmunoblastic T‐cell lymphoma and peripheral T‐cell lymphoma‐unspecified .…”

Section: Discussionmentioning

confidence: 99%

Histopathologic and immunohistological evaluation of anaplastic large cell lymphoma with Epstein–Barr virus in an orangutan (Pongo pygmaeus)

Bak

Jho²,

Woo

2014

J of Medical Primatology

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Characteristics of Epstein-Barr virus associated childhood non-Hodgkin’s lymphoma in the Republic of Korea

Cited by 13 publications

References 15 publications

Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Original paper Evaluation of the role of Epstein-Barr virus in cases of nodal or extranodal T- and NK-cell lymphoma using eber in situ hybridization

Relationship between Non-Hodgkin’s lymphoma and blood levels of Epstein-Barr Virus in children in north-western Tanzania: a case control study

Histopathologic and immunohistological evaluation of anaplastic large cell lymphoma with Epstein–Barr virus in an orangutan (Pongo pygmaeus)

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