“…In liver, kidney, and smooth muscle a rise in pH increases, while a low pH decreases, the total cell calcium (Wallach et al 1966;Rorive and Kleinzeller 1972;Van Breemen et al 1973;Studer and Borle 1979). The intracellular exchangeable calcium measured by 4s Ca uptake is also elevated by high pH and depressed at low pH in fibroblasts, lymphocytes, mast cells, smooth muscle, kidney, and Ehrlich ascites cells (Lamb and Lindsay 1971;Whitney and Sutherland 1973;Morgenstern 1972;Foreman et al 1977;Studer and Borle 1979;Hinnen et al 1979). In kidney cells, while acidosis depresses both total calcium and exchangeable calcium proportionately, alkalosis enhances the total calcium much more than the exchangeable calcium and most of the calcium gain is found in an unexchangeable pool, presumably in mitochondria (Studer and Bode 1979).…”