Characteristics of Adenovirus Pneumonia in Korean Military Personnel, 2012–2016

Yoon, Hee; Jhun, Byung Woo; Kim, Hojoong; Yoo, Hyuk Sang; Park, Sung Bum

doi:10.3346/jkms.2017.32.2.287

Cited by 23 publications

(35 citation statements)

References 24 publications

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“…Co-infection with bacteria was present in 27% of the patients, which is similar to the numbers reported in other studies [10]. In two cases, the concomitant bacterial findings were regarded as significant and likely to contribute to the patients' symptoms.…”

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confidence: 88%

“…Another limitation is that no AdV typing was performed at the time of sampling, and samples were not available for retrospective analyses. Other studies have shown that AdV-55 is common in severe infections in healthy patients [4,6,10,12]. A prospective study would be needed to estimate the true incidence of AdV pneumonia in healthy and immunocompromised adults, and to establish if specific serotypes are over-represented in immunocompetent individuals.…”

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confidence: 99%

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Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients

Cederwall

Påhlman

2019

Epidemiol. Infect.

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Adenovirus (AdV) can cause severe respiratory infections in children and immunocompromised patients, but less is known about severe AdV pneumonia in immunocompetent adults. In this retrospective study, we compared respiratory tract infections and pneumonia caused by AdV in immunocompromised and immunocompetent adult patients regarding clinical presentation and severity of infection. The results show that AdV can cause severe infections in both immunocompetent and immunocompromised patients, and the clinical presentation and need for hospitalisation, mechanical ventilation and antiviral treatment were equal in both groups. No underlying risk factors for severe AdV infection in healthy individuals were identified.

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confidence: 88%

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confidence: 99%

Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients

Cederwall

Påhlman

2019

Epidemiol. Infect.

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“…A study by the US military showed that 10% of recruits at boot camp were infected with Adv, and 90% of patients with pneumonia were infected with adenovirus [10,11]. In 2006, a study by the South Korean military reported that the prevalence of Adv was 61% among military recruits with acute respiratory symptoms [12][13][14][15][16]. Upper respiratory tract infections caused by Adv may also progress to pneumonia.…”

Section: Introductionmentioning

confidence: 99%

“…Upper respiratory tract infections caused by Adv may also progress to pneumonia. Recently, several case series were reported describing recruits that died in boot camp due to severe adenoviral pneumonia in South Korea since 2012 [13,[15][16][17]. Even if mortality results or clinical outcome of Adv infection could be affected by selection bias, it has been reported that Adv infection may be severe with a higher incidence of progression to respiratory and multiorgan failure compared to other viral etiologies with the exception of influenza.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community-acquired pneumonia

Yoo

Park

2020

Military Med Res

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Background: In 2014, an outbreak of adenoviral pneumonia occurred in the Korean military training center. However, there are limited data on the characteristics of the fever and its response to antipyretic therapy in immunocompetent adults with adenovirus-positive community-acquired pneumonia (CAP). Methods: The medical records of the patients who were admitted to the Armed Forces Chuncheon Hospital for the treatment of CAP between January 2014 and December 2016 were retrospectively analyzed. The patients were divided into three groups, namely, the adenovirus-positive (Adv) group, the adenovirus-negative (Non-Adv) group and the unknown pathogen group, according to the results of a polymerase chain reaction (PCR) test and sputum culture used to measure adenovirus and other bacteria or viruses in respiratory specimens. We evaluated and compared the demographics, clinicolaboratory findings and radiological findings upon admission between the two groups. Results: Out of the 251 military personnel with CAP during the study periods, 67 were classified into the Adv group, while 134 were classified into the Non-Adv group and 50 were classified into the unknown pathogen group. The patients in the Adv group had a longer duration of fever after admission (3.2 ± 1.6 vs. 1.9 ± 1.2 vs. 2.2 ± 1.5 days, P = 0.018) and symptom onset (5.8 ± 2.2 vs. 3.9 ± 2.5 vs. 3.7 ± 2.0 days, P = 0.006) than patients in the Non-Adv and unknown pathogen groups, respectively. The patients in the Adv group had a higher mean temperature at admission (37.8 ± 0.3 vs. 37.3 ± 0.3 vs. 37.3 ± 0.3, P = 0.005), and more patients were observed over 40 and 39 to 40(14.9% vs. 2.2% vs. 4.0%, 35.8% vs. 3.7% vs. 6.0%, P < 0.001) than those in the Non-Adv and unknown pathogen groups, respectively. The Adv group more commonly had no response or exhibited adverse events after antipyretic treatment compared to the Non-Adv group (17.9% vs. 1.5%, 35.0% vs. 4.3%, P < 0.001, P = 0.05, respectively). In addition, the time from admission to overall clinical stabilization was significantly longer in the patients in the Adv group than in those in the Non-Adv group (4.3 ± 2.8 vs. 2.9 ± 1.8 days, P = 0.034, respectively). Furthermore, no significant difference in the length of hospital stay was observed between the two groups, and no patient died in either group. Conclusion: In this study, Adv-positive CAP in immunocompetent military personnel patients had distinct fever characteristics and responses to antipyretic treatment.

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“…Adenovirus is a double-stranded DNA virus widely distributed in nature. It is mainly transmitted through the respiratory tract, causing not only upper respiratory tract infections but also pneumonia [1] . Adenovirus pneumonia is more common in children under 5 year old and immunocompromised people [2,3] and may progresses rapidly to severe pneumonia, acute respiratory distress syndrome, and even death.…”

Section: Introductionmentioning

confidence: 99%

Clinical and CT Findings of Adenovirus Pneumonia in Immunocompetent Adults, a Two-center Retrospectively Observation

Zhang

Liu

Zhang

et al. 2020

Preprint

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Background: Adenovirus pneumonia account for 5%–10% of respiratory tract infections in children. However, it is rarely observed in immunocompetent patients. We sought to describe clinical and CT characteristics of community-acquired Adenovirus pneumonia in immunocompetent adults.Methods: 20 patients with clinically diagnosed adenovirus pneumonia from two hospitals were retrospectively included from January 2018 to December 2019. Medical records and chest CT of all patients were reviewed and summarized.Results: A total of 20 patients who were consisted of 18 men and 2 women with a median age of 36 years-old (range, 18-48). The clinical findings of patients with adenovirus pneumonia is high fever (>39oC) with the normal white blood cell (WBC) count and decreased Lymphocyte and elevated C-reactive protein. 10 cases complicated with mycoplasma infection when admission. Staphylococcus epidermidis was found in blood culture of 2 patients. CT findings included consolidation in all patients, ground glass opacity (GGO) in 13 patients, and pleural effusion in 12 patients. 13 patients were mechanically ventilated and 2 patients died during hospitalization.Conclusions: The most frequent finding of adenovirus pneumonia on CT was consolidation in the early stage. In adult patients with high fever, normal WBC count and decreased Lymphocyte, consolidation with/without GGO in the early stage may be a clue for suspecting adenovirus pneumonia.

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Characteristics of Adenovirus Pneumonia in Korean Military Personnel, 2012–2016

Cited by 23 publications

References 24 publications

Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients

Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients

Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community-acquired pneumonia

Clinical and CT Findings of Adenovirus Pneumonia in Immunocompetent Adults, a Two-center Retrospectively Observation

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