Characteristics of a Highly Purified Pyrogenic Lipopolysaccharide

Pharmaceutical Sciences—1971: Literature Review of Pharmaceutics

“…These data provided additional evidence to support the idea that the ion-exchange method in a sterilizable apparatus may be designed to provide sterile water suitable for use in parenteral products. The characteristics of a highly purified pyrogenic lipopolysaccharide were described ; the principal constituents found after hydrolysis were galactose and mannose, plus unidentified fatty acids (260). A sensitive sterility test method for the detection of microbial contamination in petrolatum-based ophthalmic ointments was described by Tsuji et al (261).…”

Preparation and properties of a national reference endotoxin

“…The endotoxin described herein, extracted from Escherichia coli, is the second reference endotoxin. The first reference endotoxin, prepared from Klebsiella pneumoniae, was described previously (3,18). However, the present report contains results of parallel assays with both the E. coli and K. pneumoniae reference endotoxins.…”