Characteristics, interactions and coating adherence of heterogeneous polymer/drug coatings for biomedical devices

McManamon, Colm; Silva, Johann P. de; Delaney, Paul; Morris, Michael A.; Cross, Graham L. W.

doi:10.1016/j.msec.2015.09.103

Cited by 16 publications

(10 citation statements)

References 31 publications

(21 reference statements)

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“…Cauda et al developed a heparin-loaded PLGA coating on Double-J polyurethane stent in order to reduce incrustation [ 38 ]. However, PLGA was also successfully used as a coating on other substrates, e.g., on Ti–6Al–4V alloy in the form of a gentamicin-loaded layer intended for prosthetic hips [ 39 ]. PLGA used in our study was synthesized with Zr(acac) 4 initiator (contrary to Sn(oct) 2 in commercially available bioresorbable polyesters) and has been previously presented as a suitable polymer coating for metallic implants [ 39 , 40 , 41 , 42 , 43 ] or as a coating on Parylene C [ 44 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, PLGA was also successfully used as a coating on other substrates, e.g., on Ti–6Al–4V alloy in the form of a gentamicin-loaded layer intended for prosthetic hips [ 39 ]. PLGA used in our study was synthesized with Zr(acac) 4 initiator (contrary to Sn(oct) 2 in commercially available bioresorbable polyesters) and has been previously presented as a suitable polymer coating for metallic implants [ 39 , 40 , 41 , 42 , 43 ] or as a coating on Parylene C [ 44 ]. The possibility of encapsulating drugs within the layers provides additional advantages like local delivery of the drug, which makes it even more attractive.…”

Section: Introductionmentioning

confidence: 99%

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Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

Antonowicz

Szewczenko

Jaworska

et al. 2021

IJMS

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Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

Antonowicz

Szewczenko

Jaworska

et al. 2021

IJMS

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“…To date, various strategies have been reported to modify titanium surfaces with antibacterial properties, which mainly include: (1) loading of antibacterial drugs, such as antibiotics [3], or attaching antimicrobial peptides [4] to the surface; (2) introducing inorganic antibacterial metal elements such as F, Cu, Zn, or Ag by alloy or modification [5];…”

Section: Introductionmentioning

confidence: 99%

“…However, these methods are not only prone to drug resistance, but also usually have a burst phase at the initial stage of drug release, which prevents long-term antibacterial effects. Many methods have also been performed to introduce inorganic antibacterial metal elements to titanium surfaces, such as plasma spraying [11], micro-arc oxidation [12], and ultrasonic spray coating [3]. Compared with organic antibacterial drugs, metal elements exhibit broad-spectrum antibacterial activity, long acting time, and no drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

et al. 2021

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Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists of a mussel-inspired carboxymethyl chitosan hydrogel loaded with silver nanoparticles (AgNPs) to enhance the bioactive properties of the titanium alloy. The preparation of hydrogel is based on gallic acid grafted carboxymethyl chitosan (CMCS-GA) catalyzed by DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride). To build a firm bonding between the hydrogel and titanium alloy plate, a polydopamine layer was introduced onto the surface of the titanium alloy. With HRP/H2O2 catalysis, CMCS-GA can simply form a firm gel layer on the titanium alloy plate through the catechol groups. The surface properties of titanium alloy were characterized by scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle. Silver nanoparticles were loaded into the gel layer by in situ reduction to enhance the antibacterial properties. In vitro antibacterial and cell viability experiments showed that the AgNPs-loaded Ti-gel possesses excellent antibacterial properties and did not affect the proliferation of rabbit mesenchymal stem cells (MSCs).

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“…After proliferation stimulation, a slight decrease of cell viability was observed for all samples.When cytotoxicity was tested towards PMBC in the presence of Ag/HAP, HAP/Gr and Ag/HAP/Gr, a decrease of healthy immunocompetent PBMC cell survival up to 94.6±4.2 % for Ag/HAP, 39 72.3±4.3 % for HAP/Gr 5 and 79.6±11.2 % for Ag/HAP/Gr 36 compared to the control (S = 100 %) was calculated. According to the classification found in literature,55 all investigated samples could be declared as non-cytotoxic against target PBMC. Having in mind that PBMC cells are the first line of immune defense against any type of implant in the human body, obtained results were encouraging for further investigations.…”

mentioning

confidence: 99%

Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents

Stevanović

Djošić

Janković

et al. 2019

JSCS

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Increasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)--based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapatite is often used as part of composite biomaterials aimed for orthopedic implant applications. In order to overcome persistent problems of bacterial infection, various antimicrobial agents and materials and their incorporation in such medical devices were investigated. This paper represents a comprehensive review of single-step electrodeposition on titanium of hydroxyapatite/chitosan/graphene composite coatings loaded with silver and antibiotic gentamicin as antibacterial agents. The improvement of mechanical and adhesive properties of deposited composite coatings was achieved by graphene and chitosan addition, while desirable antibacterial properties were introduced by including antibiotic gentamicin and silver. The biocompatibility of electrodeposited HAP and HAP-based composite coatings was evaluated by MTT testing, indicating a non-cytotoxic effect and high potential for future medical use as orthopedic implant coating.

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Characteristics, interactions and coating adherence of heterogeneous polymer/drug coatings for biomedical devices

Cited by 16 publications

References 31 publications

Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents

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