Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

Sun, Yingxian; Dong, Yanli; Wang, Lifeng; Xie, Huan; Li, Baosen; Chang, Christopher; Wang, Fu Sheng

doi:10.1016/j.jaut.2020.102473

Cited by 205 publications

(226 citation statements)

References 25 publications

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“…In the single‐center study by Da et al in the United States, abnormalities in aminotransferase, lactate dehydrogenase (LDH), and ferritin levels were observed in five cases with COVID‐19‐related liver injury 73 . Sun et al found that serum ferritin was high in severe and critically ill groups ( P < .001), and was positively associated with alanine aminotransferase (ALT) ( r = .385, P = .002), aspartate transaminase (AST) ( r = .437, P < .001), and LDH ( r = .394, P = .001) levels, but not with alkaline phosphatase (ALP) and gamma‐glutamyl transferase (GGT) 74 . Multivariable analysis in the study by Phipps et al also revealed that severe acute liver injury was significantly associated with high levels of ferritin (OR 2.40, P < .001) and these subsets of patients had a more severe clinical course 75 .…”

Section: Resultsmentioning

confidence: 99%

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Cheng

et al. 2020

Clinical Laboratory Analysis

313

281

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Objective The coronavirus disease 2019 (COVID‐19) has rapidly developed into a pandemic. Increased levels of ferritin due to cytokine storm and secondary hemophagocytic lymphohistiocytosis were found in severe COVID‐19 patients. Therefore, the aim of this study was to determine the role of ferritin in COVID‐19. Methods Studies investigating ferritin in COVID‐19 were collected from PubMed, EMBASE, CNKI, SinoMed, and WANFANG. A meta‐analysis was performed to compare the ferritin level between different patient groups: non‐survivors versus survivors; more severe versus less severe; with comorbidity versus without comorbidity; ICU versus non‐ICU; with mechanical ventilation versus without mechanical ventilation. Results A total of 52 records involving 10 614 COVID‐19‐confirmed patients between December 25, 2019, and June 1, 2020, were included in this meta‐analysis, and 18 studies were included in the qualitative synthesis. The ferritin level was significantly increased in severe patients compared with the level in non‐severe patients [WMD 397.77 (95% CI 306.51‐489.02), P < .001]. Non‐survivors had a significantly higher ferritin level compared with the one in survivors [WMD 677.17 (95% CI 391.01‐963.33), P < .001]. Patients with one or more comorbidities including diabetes, thrombotic complication, and cancer had significantly higher levels of ferritin than those without (P < .01). Severe acute liver injury was significantly associated with high levels of ferritin, and its level was associated with intensive supportive care, including ICU transfer and mechanical ventilation. Conclusions Ferritin was associated with poor prognosis and could predict the worsening of COVID‐19 patients.

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Section: Resultsmentioning

confidence: 99%

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Cheng

et al. 2020

Clinical Laboratory Analysis

313

281

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“…CD4+ and/or CD8+ T‐cell counts from COVID‐19 patients with different disease severity status were reported in all 20 publications, and 10 of them also included CD19+ B cell and CD16 + CD56+ NK cell counts. These 20 peer‐reviewed publications were selected for meta‐analysis in this brief report (6‐25).…”

Section: Methodsmentioning

confidence: 99%

Lymphocyte Subset Counts in COVID‐19 Patients: A Meta‐Analysis

et al. 2020

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A reduced peripheral blood absolute lymphocyte count with an elevated neutrophil count has been a consistent observation in hospitalized coronavirus disease 2019 (COVID‐19) patients. In this brief meta‐analysis, the reduction of lymphocyte subset counts in COVID‐19 patients was investigated across 20 peer‐reviewed studies meeting criteria for reporting lymphocyte subset counts and COVID‐19 disease severity. CD4+ T cell, CD8+ T cell, B cell, NK cell, and total lymphocyte cell counts all showed statistically significant reduction in patients with severe/critical COVID‐19 disease compared to mild/moderate disease. T‐cell subsets showed the largest standardized magnitude of change. In some studies, multivariate analysis has shown that CD4 and/or CD8 T‐cells counts are independently predictive of patient outcomes. © 2020 International Society for Advancement of Cytometry

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“…Most importantly no studies conducted on post recovery patients addressing those markers. In mild-moderate COVID-19 patients the in ammatory proteins that have effect on ESR boosting maintain in their minimum level, subsequently ESR stays in their normal range 41 . Our study seems to be the rst attempt to observe those biological markers in COVID-19 post recovery patients.…”

Section: Resultsmentioning

confidence: 99%

Hypoalbuminemia in Severe COVID-19 Post Recovery Patients

Ali

Tawfeeq

et al. 2020

Preprint

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Pandemic Coronavirus disease 2019 (COVID-19) is a contagious disease affecting more than 200 countries, territories and regions. Thousands of studies have dealt with all aspects of the disease but little is known about post recovery status of the patients. Here, we examined ESR, CRP and serum albumin biomarkers in severe and mild-moderate COVID-19 post recovery patients. In severe group patients, serum albumin had a strong negative correlation with both ESR and CRP (R2= -0.861), (R2= -0.711) respectively. Also, there was a positive correlation between ESR and CRP (R2=0.85) in the same group. However, there was no correlation among mild-moderate group patients in those biomarkers. In addition, no correlation recorded between severe and mild-moderate groups. This finding concludes the sustained elevation of ESR and CRP with decreased serum albumin level in severe COVID-19 post recovery patients.

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Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

Cited by 205 publications

References 25 publications

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Lymphocyte Subset Counts in COVID‐19 Patients: A Meta‐Analysis

Hypoalbuminemia in Severe COVID-19 Post Recovery Patients

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Characteristics and prognostic factors of disease severity in patients with COVID-19: The Beijing experience

Cited by 205 publications

References 25 publications

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

Lymphocyte Subset Counts in COVID‐19 Patients: A Meta‐Analysis

Hypoalbuminemia&nbsp;in Severe COVID-19&nbsp;Post&nbsp;Recovery&nbsp;Patients

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Hypoalbuminemia in Severe COVID-19 Post Recovery Patients