Characteristics and intestinal immunomodulating activities of water‐soluble pectic polysaccharides from Chenpi with different storage periods

Chang-cheng, Tian; Xu, Huaxi; Li, Jing; Han, Ze‐Guang

doi:10.1002/jsfa.8888

Cited by 23 publications

(16 citation statements)

References 30 publications

(32 reference statements)

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“…Compared with BP, LPs had more complex monosaccharide compositions. This is similar to the finding of a previous study in that with the extension of the storage period of Chenpi, the number of types of monosaccharides increased in the polysaccharide [ 34 ]. The content of Man and Rha in BP was much higher than that in the LPs, whereas the monosaccharide compositions present in the LPs were typical for pectic polysaccharides, which mainly consisted of Rha, Gal, and Gal-A [ 35 ].…”

Section: Resultssupporting

confidence: 91%

Effect of Bergamot and Laoxianghuang Polysaccharides on Gut Microbiota Derived from Patients with Hyperlipidemia: An Integrative Analysis of Microbiome and Metabolome during In Vitro Fermentation

Yang

Wang

Luo

et al. 2022

Foods

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The aim of this study was to investigate the effects of bergamot polysaccharide (BP) and Laoxianghuang polysaccharides (LPs, fermented bergamot) on the microbiome and metabolome during the in vitro fermentation of gut microbiota from patients with hyperlipidemia. Results indicated that both BP and LPs were able to increase the production of acetic acid, propionic acid, and butyric acid. However, only LPs could decrease the content of isobutyric acid and isovaleric acid, which are detrimental to gut health. A 16S rRNA analysis showed that both BP and LPs could reduce the proportion of Fusobacterium, whereas they increased the Bacteroides content in hyperlipidemia. Untargeted UPLC-MS/MS metabolomic profiling found six bio-markers that were significantly changed after BP and LPs intervention, and four of the down-regulated metabolites were long-chain fatty acids associated with vascular diseases. These findings provide new evidence that BP and LPs have the potential to regulate imbalances in the gut microbiota in patients with hyperlipidemia and ameliorate its metabolic abnormalities.

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Section: Resultssupporting

confidence: 91%

Effect of Bergamot and Laoxianghuang Polysaccharides on Gut Microbiota Derived from Patients with Hyperlipidemia: An Integrative Analysis of Microbiome and Metabolome during In Vitro Fermentation

Yang

Wang

Luo

et al. 2022

Foods

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“…CRP has long been used in traditional medicine for treating digestive tract diseases and anti-inflammatory diseases; it is also used as a seasoning in cooking and as a dietary supplement (13). Studies have shown that its extracts and active ingredients may improve glycolipid metabolism disorder by regulating the gut microbiome (14)(15)(16)(17). Therefore, CRP extract was selected as an intervention drug in this study and its possible mechanism in glycolipid metabolism disorder was explored in juvenile C57BL/6 mice referred to existing researches (4,5).…”

Section: Introductionmentioning

confidence: 99%

Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life

You

Zhou

et al. 2021

Front. Immunol.

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BackgroundStudies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.PurposeThe study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder via regulation of gut microbiome in mice exposed to antibodies early in life were investigated.Methods and ResultsThree-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. The results showed that early-life AZT exposure promoted HFD-induced glycolipid metabolism disorder, increased the levels of inflammatory factors, promoted the flora metabolism product trimethylamine N-oxide (TMAO), and induced microbial disorder in adult mice. Importantly, CRP extract mitigated these effects.ConclusionTaken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome.

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“…The changes of odor efficacy may be attributed to the dynamic variation of phytochemical and volatile compounds. Tian et al (2018) demonstrated that the water-soluble pectic polysaccharides obtained from CRP stored for a long period contained more conjugated phenolic acids and stronger intestinal activities compared with that obtained from fresh CRP. Luo et al (2019) have found different phytochemical metabolites in CRP with different storage years.…”

Section: Introductionmentioning

confidence: 98%

Dynamic variation of the phytochemical and volatile compounds in the pericarp ofCitrus reticulata‘‘Chachi’’ (Rutaceae) during 2 years of storage

Chao

Tan

et al. 2021

Journal of Food Science

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The pericarp of Citrus reticulata "Chachi" (CRCP) is used as nutritional food and traditional medicine in China, usually harvested at three periods, namely, immature (CRCP-G1), semi-mature (CRCP-G2), and fully mature (CRCP-G3). Traditionally, if the CRCP is stored for a longer period, then the quality will be better. In this study, the dynamic variation of phytochemical and volatile compounds was profiled in the same batches of CRCP during 2 years of storage. Results illustrated that most of the phytochemical compounds showed a decreasing trend during storage, that is, total flavonoids, total phenolic acids, hesperidin,

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Characteristics and intestinal immunomodulating activities of water‐soluble pectic polysaccharides from Chenpi with different storage periods

Cited by 23 publications

References 30 publications

Effect of Bergamot and Laoxianghuang Polysaccharides on Gut Microbiota Derived from Patients with Hyperlipidemia: An Integrative Analysis of Microbiome and Metabolome during In Vitro Fermentation

Effect of Bergamot and Laoxianghuang Polysaccharides on Gut Microbiota Derived from Patients with Hyperlipidemia: An Integrative Analysis of Microbiome and Metabolome during In Vitro Fermentation

Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life

Dynamic variation of the phytochemical and volatile compounds in the pericarp ofCitrus reticulata‘‘Chachi’’ (Rutaceae) during 2 years of storage

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