Characteristics and Advantages of Traditional Chinese Medicine in the Treatment of Acute Myocardial Infarction

Liu, Hongxu; Shuo-ren, Wang; Yan, Lei; Shang, Juju

doi:10.1016/s0254-6272(12)60002-8

Cited by 48 publications

(34 citation statements)

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“…Thus, it is of great significance to explore the pathogenesis of AMI and to find effective medications. As the frequent and successful use of Traditional Chinese Medicine (TCM) in the prevention and treatment for coronary heart disease (CHD), the effects of TCM for CHD have aroused increasing attention …”

Section: Discussionmentioning

confidence: 99%

“…As the frequent and successful use of Traditional Chinese Medicine (TCM) in the prevention and treatment for coronary heart disease (CHD), the effects of TCM for CHD have aroused increasing attention. [59] Danshen (Salvia miltiorrhiza Bunge) is a traditional medicine that has been used in China for over a thousand years to treat various diseases, including coronary artery disease, cerebrovascular disease, heart disease, hepatitis and cancer. [60] Sal B is one of the most abundant and bioactive members of salvianolic acids in Danshen [61] and has been approved by the Chinese State Food and Drug Administration as a cardioprotective agent for the treatment of coronary artery disease since March 2005 (State Drug Permit Doc:Z20050249).…”

Section: Discussionmentioning

confidence: 99%

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Cardioprotective effect of Salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis

Chao

Liu

Lü

et al. 2016

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cardioprotective effect of Salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis

Chao

Liu

Lü

et al. 2016

Journal of Pharmacy and Pharmacology

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“…In China, traditional Chinese herbal medicine has been used to prevent and treat cardiovascular system diseases, including arrhythmia, for thousands of years. Several studies have shown that a combination of traditional Chinese herbal medicine and conventional western medicine could prevent significantly the occurrence of malignant arrhythmia and reduce the mortality caused by SCD in MI patients [11–13]. …”

Section: Introductionmentioning

confidence: 99%

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

Zhao

Lou

et al. 2017

BioMed Research International

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Myocardial infarction (MI) patients are at high risk of potential lethal arrhythmia. Gap junction and microRNA-1 (miR-1) are both arrhythmia generating conditions. The present study investigated whether Wenxin Granules (Wenxin-Keli, WXKL) could prevent potential lethal arrhythmia by improving gap junctions and miR-1 following MI. Male Sprague-Dawley rats were divided randomly into control, model, metoprolol, low dose WXKL, and high dose WXKL groups. The MI rat model was created by coronary artery ligation. Treatments were administrated intragastrically to the rats for 4 weeks. Conventional transmission electron microscopy was performed to observe the ultrastructure of gap junctions. Quantitative real-time PCR and western blotting were used to detect the expression of miR-1, protein kinase C (PKC), and related proteins. Additionally, a programmatic electrophysiological stimulation test was performed to detect the ventricular fibrillation threshold (VFT). WXKL protected the ultrastructure of the gap junctions and their constituent Cx43 by regulating miR-1 and PKC mediated signal transduction and increased the VFT significantly in the rat MI model. The results suggested that WXKL is an effective alternative medicine to prevent potentially lethal arrhythmia following MI.

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“…[232425474849] However, as nonguideline-recommended medicine, traditional Chinese medicines have been reported to have some advantages for the treatments of AMI. [50] However, the safety and components of these traditional therapies remain uncertain. [51] Well-designed and performed randomized controlled trials are needed to validate the beneficial effects of traditional Chinese medicines on the management of STEMI.…”

Section: Discussionmentioning

confidence: 99%

Current Trends for ST-segment Elevation Myocardial Infarction during the Past 5 Years in Rural Areas of China's Liaoning Province

Zhou

et al. 2017

Chinese Medical Journal

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Background:Since 2010, two versions of National Guidelines aimed at promoting the management of ST-segment elevation myocardial infarction (STEMI) have been formulated by the Chinese Society of Cardiology. However, little is known about the changes in clinical characteristics, management, and in-hospital outcomes in rural areas.Methods:In the present multicenter, cross-sectional study, participants were enrolled from rural hospitals located in Liaoning province in Northeast China, during two different periods (from June 2009 to June 2010 and from January 2015 to December 2015). Data collection was conducted using a standardized questionnaire. In total, 607 and 637 STEMI patients were recruited in the 2010 and 2015 cohorts, respectively.Results:STEMI patients in rural hospitals were older in the second group (63 years vs. 65 years, P = 0.039). We found increases in the prevalence of hypertension, prior percutaneous coronary intervention (PCI), and prior stroke. Over the past 5 years, the cost during hospitalization almost doubled. The proportion of STEMI patients who underwent emergency reperfusion had significantly increased from 42.34% to 54.47% (P < 0.0001). Concurrently, the proportion of primary PCI increased from 3.62% to 10.52% (P < 0.0001). The past 5 years have also seen marked increases in the use of guideline-recommended drugs and clinical examinations. However, in-hospital mortality and major adverse cardiac events did not significantly change over time (13.01% vs. 10.20%, P = 0.121; 13.34% vs. 13.66%, P = 0.872).Conclusions:Despite the great progress that has been made in guideline-recommended therapies, in-hospital outcomes among rural STEMI patients have not significantly improved. Therefore, there is still substantial room for improvement in the quality of care.

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Characteristics and Advantages of Traditional Chinese Medicine in the Treatment of Acute Myocardial Infarction

Cited by 48 publications

References 0 publications

Cardioprotective effect of Salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis

Cardioprotective effect of Salvianolic acid B on acute myocardial infarction by promoting autophagy and neovascularization and inhibiting apoptosis

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

Current Trends for ST-segment Elevation Myocardial Infarction during the Past 5 Years in Rural Areas of China's Liaoning Province

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