Characteristics Affecting Survival after Locally Advanced Colorectal Cancer in Quebec

Perron, Linda; Daigle, Jean-Marc; Vandal, Nathalie; Guertin, Marie-Hélène; Brisson, Jacques

doi:10.3747/co.22.2692

Cited by 10 publications

(9 citation statements)

References 34 publications

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“…The tumor invasion in other organs was a negative prognostic factor in our study, similar to other published research (29)(30)(31)(32).…”

Section: Discussionsupporting

confidence: 92%

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Constantin¹,

Firescu²,

Voicu³

et al. 2020

chr

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Introducere: În anul 2018 cancerul de colon se afla pe locul al 5-lea ca mortalitate prin cancer, iar cancerul rectal pe locul al 10-lea. Supravieţuirea la distanţă a bolnavilor cu cancer colorectal operat în urgenţă, rămâne nesatisfăcătoare, decesul fiind datorat recidivelor locale şi a metastazelor. Scopul: Evaluarea unor corelaţii ale supravieţuirii globale cu caracteristici clinico-paraclinice, tumorale sau de tratament pentru identificarea factorilor de prognostic la pacienţii cu cancer colorectal operat în urgenţă. Material şi Metode: Am efectuat o analiză retrospectivă la 431 pacienţi cu cancer colorectal operat în urgenţă în perioada 2008-2017, cu excluderea celor 40 de pacienţi cu decese postoperatorii, cu o perioadă de urmărire de cel puţin un an. S-au efectuat corelaţii ale unor caracteristici clinico-paraclinice, tumorale sau de tratament cu supravieţuirea globală. Rezultate: În analiza statistic univariată de supravieţuire, se obţine o asociere semnificativă statistic cu: vârsta > 61 ani (p_value = 0.000049), antecedentele chirurgicale abdominal (p_value = 0,031725), bolile cardiace (p_value = 0,000007), fibrilaţia atrială (p_value = 0,007496), diagnosticul la internare (p_value = 0,034352), caşexia (p_value = 0,000000), oligoanuria (p_value = 0,000000), anemia (p_value = 0,000006) dezechilibrul hidroelectrolitic (p_value = 0,000001), localizarea tumorală (p_value = 0,000030), invazia în organele vecine (p_value = 0,000000), aspectul de pelvis îngheţat (p_value = 0,000000), carcinomatoza peritoneală (p_value = 0,000000), metastazele hepatice (p_value=0,000000), tipul de intervenţie chirurgicală (p_value = 0,000000), limfodisecţia (p_value = 0,000001), biopsia hepatică (p_value = 0,043483), reintegrarea tranzitului intestinal (p_value = 0,000000), intervenţiile seriate (p_value = 0,000000), pTNM (p_value = 0,000000), gradingul (p_value = 0,007069). Analiza de regresie multivariată Cox a arătat că: vârsta > 61 ani-HR=1.026, 95%CI(1.012, 1.039) (p_value = 0.000139), caşexia-HR = 1.358, 95%CI(1.046, 1.764) (p_value = 0,021617), carcinomatoza peritoneală-HR = 2.346, 95%CI(1.163, 4.732) (p_value = 0,017253), stadiul bolii-HR=36.745, 95%CI = (14.778, 91.366) (p_ value = 0,000000), tipul de intervenţie-HR = 0.187, 95%CI(0.045, 0.779) (p_ value = 0,021281) şi intervenţiile seriate-HR = 0.282, 95% CI(0.144,0.551) (p_ value = 000213) sunt factori de prognostic independenţi. Concluzii: Factorii de prognostic pentru bolnavii cu cancere colorectale operate în urgenţă sunt: vârsta > 61 ani, prezenţa antecedentelor chirurgicale abdominale şi a tarelor cardiace asociate, în special a fibrilaţiei atriale, diagnosticul de iminenţă de perforaţie diastatică, caşexia, oligoanuria, anemia şi dezechilibrul hidro-electrolitic prezente la internare, tumorile rectale, invazia tumorală în organe vecine, aspectul de "pelvis îngheţat", prezenţa metastazelor hepatice sau a carcinomatozei peritoneale, tumorile nediferenţiate, stadiul III sau IV, practicarea unei derivaţii interne sau neefectuarea limfodisecţiei. Vârsta peste 61 de ...

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“…The tumor invasion in other organs was a negative prognostic factor in our study, similar to other published research (29)(30)(31)(32).…”

Section: Discussionsupporting

confidence: 92%

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Constantin¹,

Firescu²,

Voicu³

et al. 2020

chr

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“…Colorectal cancer is considered primarily a "lifestyle" disease. The literature shows that demographic variables, such as age, gender, familial CRC history, diets high in calories and animal fat, alcohol consumption, and obesity, in addition to other factors, such as tumor site, size, grade, histologic type, TNM stage, and carcinoembryonic antigen (CEA) level, have all been found to significantly affect survival in CRC [3,[10][11][12][13]. In the present study, we used population-based data from the Taiwan Cancer Database of the medical center hospital in North Taiwan to compare socio-demographic and clinic-pathological characteristics, prognostic factors, and overall survival between 2 groups of CRC patients, i.e., those with the colon or rectum as the primary site.…”

Section: Introductionmentioning

confidence: 99%

Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan

Lee¹,

Tseng²,

Tung³

et al. 2020

aoms

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Introduction: Colorectal cancer (CRC) is rapidly increasing in developed countries. In Taiwan, the incidence rate of CRC has increased during the past decade, but the 5-year survival has remained at approximately 63%. In this study, we sought to determine the 5-year survival rate of patients diagnosed with colon and rectum cancer and to determine factors affecting survival. Material and methods: All patients from the Taiwan Cancer Database of the medical center hospital in North Taiwan between 2007 and 2013 were identified. Survival analysis was performed using Kaplan-Meier curves, and differences between the curves were analyzed using the log-rank test. Cox proportional hazards regression models were used to analyze survival by each variable. Results: A total of 869 patients were included: 554 (63.8%) patients had colon cancer and 315 (36.2%) had rectum cancer. The mean survival time was 71.27 ±1.27 months (colon group: 71.90 ±1.58 months; rectum group: 67.88 ±1.95 months). There was no significant difference (p = 0.493) between patients who had colon or rectum cancer. The forward stepwise Cox regression analysis results indicated that perineural invasion, distant metastasis, age, pathological differentiation grade, and obstruction were statistically significant for patients who had CRC, colon cancer or rectum cancer. Conclusions: The long-term survival from CRC, colon cancer and rectum cancer remains promising, as 68.66%, 69.11% and 67.90% of patients are alive 5 years after being diagnosed, respectively. Perineural invasion was found to be an important factor related to the survival of patients who have CRC. Thus, early detection of CRC may help improve survival.

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“…Many demography and clinicopathological variables have been observed as predictors for overall survival (OS) and DFS in patients with colon cancer receiving adjuvant chemotherapy. These included age (12), sex (13,14), disease stage (11,15), performance status (16), tumor invasion (12,13,15,(17)(18)(19), lymph nodes removed (15,18,(20)(21)(22), and histological grade (18). Multiple reports showed that treatment characteristics such as the type of regimen (23,24), time to start treatment after surgical resection (25,26), number of cycles of chemotherapy administration (3,4,27), and dose of oxaliplatin used (5,13) also predicted the patients' survival.…”

Section: Introductionmentioning

confidence: 99%

Effects of oxaliplatin-containing adjuvant chemotherapy on short-term survival of patients with colon cancer in Dr. Sardjito Hospital, Yogyakarta, Indonesia

Wardhani

Hutajulu

Ferianti

et al. 2019

J. Gastrointest. Oncol

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Background: Oxaliplatin-based adjuvant chemotherapy has been applied as standard treatment for high risk stages II and III colon cancer in many countries. There was no comprehensive report of oxaliplatin use in Indonesia. This research aimed to evaluate the short-term survival of patients with colon cancer treated with such strategy and the prognostic factors. Methods: Medical records of patients with colon cancer receiving oxaliplatin-containing adjuvant chemotherapy were retrospectively reviewed. Demography, clinicopathological, and treatment data were collected. Two-year overall survival (OS) and disease-free survival (DFS) were calculated using Kaplan-Meier method and survival predictors were estimated using Cox proportional hazard models. Results: Data of 81 patients had been included with a median follow-up of 25.2 months. The estimated OS and DFS at 2 years were 75.8% and 72.7%. In multivariate analyses, the Eastern Cooperative Oncology Group (ECOG) 2 performance status [hazard ratio (HR) =2.967; 95% confidence interval (CI), 1.265 to 6.957; P=0.012], T4 stage (HR =2.669; 95% CI, 1.087 to 6.557; P=0.032), and less cycles of chemotherapy administration (HR =3.280; 95% CI, 1.333 to 8.070; P=0.010) were significant independent factors for an increased risk of death. Cases with moderately to poorly differentiated tumors had significantly worse DFS compared with those with well differentiated tumors (HR =3.503; 95% CI, 1.403 to 8.744; P=0.007). Conclusions: Colon cancer patients receiving oxaliplatin-based adjuvant regimens in our clinical practice had 2-year OS rate of 75.8% and 2-year DFS rate of 72.7%. ECOG 2 performance status, T4 stage, and less cycles of chemotherapy administration significantly predicted a poor OS and moderately to poorly histological grade significantly predicted a poor DFS.

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Characteristics Affecting Survival after Locally Advanced Colorectal Cancer in Quebec

Abstract: BackgroundWe estimated the relations of sociodemographic, organizational, disease, and treatment variables

Cited by 10 publications

References 34 publications

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan

Effects of oxaliplatin-containing adjuvant chemotherapy on short-term survival of patients with colon cancer in Dr. Sardjito Hospital, Yogyakarta, Indonesia

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