Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan

Abstract

Introduction: Colorectal cancer (CRC) is rapidly increasing in developed countries. In Taiwan, the incidence rate of CRC has increased during the past decade, but the 5-year survival has remained at approximately 63%. In this study, we sought to determine the 5-year survival rate of patients diagnosed with colon and rectum cancer and to determine factors affecting survival. Material and methods: All patients from the Taiwan Cancer Database of the medical center hospital in North Taiwan between 2007 and 2013 were identified. Survival analysis was performed using Kaplan-Meier curves, and differences between the curves were analyzed using the log-rank test. Cox proportional hazards regression models were used to analyze survival by each variable. Results: A total of 869 patients were included: 554 (63.8%) patients had colon cancer and 315 (36.2%) had rectum cancer. The mean survival time was 71.27 ±1.27 months (colon group: 71.90 ±1.58 months; rectum group: 67.88 ±1.95 months). There was no significant difference (p = 0.493) between patients who had colon or rectum cancer. The forward stepwise Cox regression analysis results indicated that perineural invasion, distant metastasis, age, pathological differentiation grade, and obstruction were statistically significant for patients who had CRC, colon cancer or rectum cancer. Conclusions: The long-term survival from CRC, colon cancer and rectum cancer remains promising, as 68.66%, 69.11% and 67.90% of patients are alive 5 years after being diagnosed, respectively. Perineural invasion was found to be an important factor related to the survival of patients who have CRC. Thus, early detection of CRC may help improve survival.

Chronic Obstructive Pulmonary Disease and Its Acute Exacerbation before Colon Adenocarcinoma Treatment Are Associated with Higher Mortality: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study

“…Furthermore, we showed that hospitalization for AECOPD within 1 year before surgical resection was an independent prognostic factor for survival in patients receiving standard treatments for stage I–III colon adenocarcinoma; patients with more frequent hospitalizations for AECOPD (≥2 within 1 year before surgical resection) before colon adenocarcinoma treatments had poorer survival outcomes than did those with less frequent AECOPD hospitalizations before colon adenocarcinoma treatments. In addition, our study results are compatible with those of previous studies, which have identified age, comorbidity, cigarette smoking status, histological differentiation, perineural invasion, lymphovascular invasion, and AJCC pathologic stages as independent predictors of OS [ 26 , 27 , 28 , 29 , 30 ]. The present study is the first to identify hospitalization frequency for AECOPD before colon adenocarcinoma treatments as a severity-dependent independent prognostic factor for the OS of patients with stage I–III colon cancer receiving surgical resection and standard treatments.…”

Clinical Correlation of Wnt2 and COL8A1 With Colon Adenocarcinoma Prognosis

“…Studies show that the 5-year survival rate of individuals with COAD is 65% in the United States, with 5-year survival rate of stage I and II COAD patients ranging from 80 to 90%, whereas that of patients with stage III and IV metastatic diseases being 60–71 and 8–13%, respectively. Further, Fang et al have reported 5-year survival rates of 74.3% for stage I, 76.6% for stage II, 56.6% for stage III, and only 16.7% for stage IV ( 2 , 3 ). Accordingly, early and timely diagnosis and treatment of colon cancer are very important for favorable patient prognosis.…”

A five-year follow up study of stage I-IV of rectal cancer with an emphasis on epidermal growth factor over-expression

“…The multivariate analysis also showed that high EGFR intensity increases the risk of cancer recurrence 4.3 times (HR = 4.3). Interestingly, our study showed that among patients with high EGFR levels, patients with pT4 predominated (p = 0.0003), although some researchers claim that the correlation between the EGFR overexpression and clinical-pathological parameters is not important [2,23,24,25]. According to them, this may be only an additional molecular phenomenon that causes poor test results.…”