Characteristic Features of the Genotype of Extremely Premature Children With Adverse Outcome

Abstract

The aim of the research was to study the polymorphism of the genes of the detoxification system and genes of the main histocompatibility complex HLA class II in premature infants with a birth weight of less than 1500 g and a gestation period of less than 32 weeks. Materials and methods of research: 103 extremely premature infants without congenital malformations, having respiratory disorders and requiring respiratory therapy in one volume or another, were under observation. All children were divided into 2 groups: 1st – 81 extremely premature babies with favorable outcome (recovery); 2nd – 22 children with unfavorable outcome (death, disability). Results: an association was established between the presence of DQA1*0301 alleles in the genotype and the development of unfavorable outcome in extremely premature infants with respiratory pathology (p=0.041). In addition, the genotype GSTM1+/+ GSTT1+/+ DRB1*13 DQA1*0301 DQB1*0602 was determined only in children with poor outcomes (p=0.041). The presence of genotypes GSTM1 – GSTT1+/+ DRB1*11 DQA1*0501 DQB1*0301 and GSTM1 – GSTT1+/+ DRB1*15 DQA1*0102 DQB1*0602 17 times, and the presence of the DQA1*0401 allele 8 times increases the risk of death (p=0.028).