Characteristic Features of Mueller Matrix Patterns for Polarization Scattering Model of Biological Tissues

Abstract

We developed a model to describe polarized photon scattering in biological tissues. In this model, tissues are simpli¯ed to a mixture of scatterers and surrounding medium. There are two types of scatterers in the model: solid spheres and in¯nitely long solid cylinders. Variables related to the scatterers include: the densities and sizes of the spheres and cylinders, the orientation and angular distribution of cylinders. Variables related to the surrounding medium include: the refractive index, absorption coe±cient and birefringence. In this paper, as a development we introduce an optical activity e®ect to the model. By comparing experiments and Monte Carlo simulations, we analyze the backscattering Mueller matrix patterns of several tissue-like media, and summarize the di®erent e®ects coming from anisotropic scattering and optical properties. In addition, we propose a possible method to extract the optical activity values for tissues. Both the experimental and simulated results show that, by analyzing the Mueller matrix patterns, the microstructure and optical properties of the medium can be obtained. The characteristic features of Mueller matrix patterns are potentially powerful tools for studying the contrast mechanisms of polarization imaging for medical diagnosis.

Mueller matrix polarimetry for characterizing microstructural variation of nude mouse skin during tissue optical clearing

“…In previous studies, we have established a series of scattering models and the corresponding Monte Carlo simulation programs to study the polarized photon scattering in complex anisotropic turbid media. The scattering models consist of spherical and infinitelylong cylindrical scatterers [7], which mimic the scatterings by particles such as the cells and intracellular organelles and by fibrous structures such as skeletal muscle fibers [26,27], and an interstitial medium, which takes into account all the none scattering effects during the propagation of the photons such as birefringence and optical activities [28,29]. The models are simple, but very versatile for adapting to different types of turbid media.…”

Evolution of raw meat polarization‐based properties by means of Mueller matrix imaging

“…12,[23][24][25] Among different polarimetric techniques, MM polarimetry is the one, which can provide a complete characterization of the polarimetric properties (including diattenuation, dichroism, and depolarization) in addition to microstructural and optical information of a scattering media such as biological tissues. [26][27][28][29] Therefore, MMIP is becoming increasingly attractive for distinguishing the structural features of biological tissue in food quality control and medical diagnostics. 18,24,28,[30][31][32][33][34][35][36][37] Optical characterization of biological tissue within the framework of the Stokes-Mueller formalism is based on measuring the bulk tissue's polarimetric transfer function, known as its Mueller matrix.…”

Polypeptide-engineered physical hydrogels designed from the coiled-coil region of cartilage oligomeric matrix protein for three-dimensional cell culture

“…The ability to control cell-binding ligand type and density, and thus to study their effects on 2-D cell adhesion and 3-D cell growth and migration, has proven to be a useful strategy for understanding specic cell-materials interactions and the basic mechanism. [36][37][38] The precursor of photo-cross-linked hydrogels facilitated making hydrogels with similar mechanical properties and tuning the RGD ligand density. Because the polypeptide P is biosynthesized by gene engineering, the modular design of our engineered polypeptide facilitates the creation of identical P that differ only in the numbers of bioactive RGD ligand.…”