Characterising the allergic profile of children with cystic fibrosis

Faulkner, Amy L; Grayling, Michael J.; Shillitoe, Benjamin; Brodlie, Malcolm; Michaelis, Louise J.

doi:10.1002/iid3.540

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The exact reason for this association between EoE, CF and atopic diseases is unclear but altered esophageal microbiome, dysregulated interactions between microbiota and gut mucosal immunity, could be a potential link between these conditions [ 12 13 14 15 16 17 ]. Similarly, prolonged antibiotic exposure in CF patients could predispose to atopic disorders via Th2 skewing [ 18 19 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Eosinophilic Esophagitis in Patients with Cystic Fibrosis: A Population-Based 5-Year Study

Alaber

Sabe

Baez-Socorro

et al. 2022

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

Purpose The prevalence of eosinophilic esophagitis (EoE) has been on the rise since it was first described in the 1990s. Several diseases and exogenous factors have been associated with EoE. Our aim was to investigate the epidemiology of EoE in cystic fibrosis (CF) patients. Methods We identified individuals with CF from September 2014 to September 2019 within a database (IBM Explorys Solutions, Inc.). The prevalence of EoE in patients with CF was compared to the general population. Results The database included 36,111,860 patients during the 5-year study period: 12,950 with CF (0.036%) and 28,090 with EoE (0.078%). EoE prevalence was higher in CF patients than the general population (46 in 10,000 vs. 7.8 in 10,000, p <0.001). Patients with CF and EoE were more likely to be male (50% vs. 33.5%, p <0.008), children (33.3% vs. 16.5%, p <0.001), and non-Hispanic (100% vs. 88.7%, p <0.001) than CF patients without EoE. CF with EoE patients were more likely to be children than EoE only (33.3% vs. 10.5%, p <0.001). Allergic conditions were generally more prevalent in CF with EoE than CF only (83.3% vs. 68.3%, p =0.01) and EoE only (83.3% vs. 69.3%, p =0.014). Conclusion EoE is nearly 6-times more prevalent in CF patients. Those patients had higher incidence of other atopic conditions. EoE must be considered in the differential diagnosis of patients with CF presenting with dysphagia, refractory gastroesophageal reflux, vomiting, and other esophagus-related symptoms.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiology of Eosinophilic Esophagitis in Patients with Cystic Fibrosis: A Population-Based 5-Year Study

Alaber

Sabe

Baez-Socorro

et al. 2022

Pediatr Gastroenterol Hepatol Nutr

View full text Add to dashboard Cite

show abstract

“…There are studies showing an increase in allergic response to Af in some pwCF who do not meet diagnostic criteria for ABPA [ 74 ]. While many of these investigations were conducted some time ago on earlier birth cohorts, pwCF were generally found to have more frequent IgE-positive allergy testing to various allergens including that of Af [ 75 , 76 , 77 ]. This was seen to increase with age and associated with symptoms consistent with asthma and other atopic conditions [ 36 , 78 ].…”

Section: Clinical Management Of Af Infections In Pwcfmentioning

confidence: 99%

Infection, Allergy, and Inflammation: The Role of Aspergillus fumigatus in Cystic Fibrosis

Poore

Zemanick

2023

Microorganisms

View full text Add to dashboard Cite

Aspergillus fumigatus (Af) is a mold frequently detected in airway samples from people with cystic fibrosis (pwCF). Abnormal airway mucus may allow Af to germinate, resulting in airway infection or an allergic response. While Af is known to increase morbidity in pwCF, individual responses and the degree of impact on lung disease vary. Improved approaches to diagnosis, treatment, and prevention of Af, particularly the persistent Af infection, are needed. This update highlights our current understanding of Af pathophysiology in the CF airway, the effects of Af on pwCF, and areas of research needed to improve clinical outcomes.

show abstract

Characterising the allergic profile of children with cystic fibrosis

Faulkner

Grayling

Shillitoe

et al. 2021

Immunity Inflam & Disease

Self Cite

View full text Add to dashboard Cite

Background: Cystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) is a wellrecognised problem but other allergic conditions are less well documented in CF.Objective: To characterise the allergic profile of a cohort of children with CF, with a focus on those with ABPA.Methods: A cohort of children with CF were interviewed and retrospective data were collected regarding their allergic histories and other relevant clinical features. Results:The cohort included 37 children with median age of 9 years (interquartile range: 6-12). There was a history of ≥1 allergic condition(s) in 28/37 children (76%). The most common allergic condition was allergic rhinitis (AR) in 21/37 (57%) and 16 of these 21 children (76%) had another allergic condition. All children with ABPA (8) had another allergic condition. In some children ABPA exacerbations appeared to be seasonal, suggesting possible cross-sensitisation between Aspergillus fumigatus and aeroallergens associated with seasonal AR. Allergic conditions were also common in children with Pseudomonas aeruginosa infection.

show abstract

Characterising the allergic profile of children with cystic fibrosis

Cited by 3 publications

References 37 publications

Epidemiology of Eosinophilic Esophagitis in Patients with Cystic Fibrosis: A Population-Based 5-Year Study

Epidemiology of Eosinophilic Esophagitis in Patients with Cystic Fibrosis: A Population-Based 5-Year Study

Infection, Allergy, and Inflammation: The Role of Aspergillus fumigatus in Cystic Fibrosis

Characterising the allergic profile of children with cystic fibrosis

Contact Info

Product

Resources

About