Characterisation of the oral adjuvant effect of lemnan, a pectic polysaccharide of Lemna minor L.

Inhibition of LPS-induced proinflammatory responses of J774.2 macrophages by immobilized enzymatically tailored pectins

“…We have previously shown that immobilized modified hairy regions (MHRs) of pectin influence the morphology, adhesion, cell cycle progression and survival of fibroblasts [10]. Numerous studies have shown that pectic polysaccharides are potentially important immunomodulatory agents that may, for example, increase the synthesis of Fc-receptors by macrophages [11], enhance the capacity of phagocytes [12], increase the adhesion of macrophages and production of oxygen radicals [13,14], or influence complement fixing activities, proinflammatory cytokine secretion and chemotaxis of macrophages [15][16][17][18].…”

Chemical composition and immunomodulatory activity of a pectic polysaccharide from the ground thistle Cirsium esculentum Siev.

“…The decreasing of IgE-response is confirmed by Lee et al (2004) showed that the administration of Asian pear pectin-sol in presensitised mice suppressed IgE production and an allergic asthma symptoms severity. Our previous results indicate that oral administration of OVA and lemnan, apiogalacturonanic pectin of duckweed Lemna minor L., failed to elevate levels of either total and antigen-specific IgE responses (Popov et al, 2006).…”

“…Dietary pectin-derived acidic oligosaccharides enhanced systemic Th1-dependent immune responses in a murine vaccination model (Vos et al, 2007). In contrast, apiogalacturonanic pectin of duckweed Lemna minor L. named lemnan appeared to elicit adjuvant activity via induction of both Th1 and Th2-type responses (Popov et al, 2006). The dose of pectin used was approximately equivalent to the estimated pectin intake in humans (4 g/day).…”

“…An acidic polysaccharide fraction prepared from a constituent herb of Juzen-taiho-to has been shown to have a protective activity against Candida-infected mice (Inagaki et al, 2001). An adjuvant effect has been noted for apiogalacturonan from duckweed Lemna minor L. (Popov et al, 2006). But all of these pectins were isolated from various medicinal plants, which are not present in the diet.…”

Food‐Related Carbohydrate Ligands for Galectins

“…Interestingly, a structural investigation of a fractionated pectin revealed that its biological activity was determined by the galactose side chains in arabinogalactan II (46). The immunoadjuvant effect of dietary pectins such as lemnan may result from an enhanced antigen ingestion and stimulation of macrophage activity (47). Stimulation of the innate immune system by pectin was determined as a possible mechanism of the polysaccharide protection against systemic pneumococcal infection in mice (48).…”