Characterisation of the inhomogeneity of sol–gel-derived SiO2–CaO bioactive glass and a strategy for its improvement

Lin, Sen; Ionescu, Claudia; Baker, Susan C.; Smith, Mark E.; Jones, Julian R.

doi:10.1007/s10971-009-2085-0

Cited by 34 publications

(34 citation statements)

References 18 publications

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“…1 cm) monoliths are made, this can cause inhomogeneity of the calcium distribution owing to large diffusion distances [48]. This is less prominent in foams as the struts are relatively thin [49].…”

Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Martin

Sheng

Hanna

et al. 2012

Phil. Trans. R. Soc. A.

122

106

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Bone is the second most widely transplanted tissue after blood. Synthetic alternatives are needed that can reduce the need for transplants and regenerate bone by acting as active temporary templates for bone growth. Bioactive glasses are one of the most promising bone replacement/regeneration materials because they bond to existing bone, are degradable and stimulate new bone growth by the action of their dissolution products on cells. Sol-gel-derived bioactive glasses can be foamed to produce interconnected macropores suitable for tissue ingrowth, particularly cell migration and vascularization and cell penetration. The scaffolds fulfil many of the criteria of an ideal synthetic bone graft, but are not suitable for all bone defect sites because they are brittle. One strategy for improving toughness of the scaffolds without losing their other beneficial properties is to synthesize inorganic/organic hybrids. These hybrids have polymers introduced into the sol-gel process so that the organic and inorganic components interact at the molecular level, providing control over mechanical properties and degradation rates. However, a full understanding of how each feature or property of the glass and hybrid scaffolds affects cellular response is needed to optimize the materials and ensure long-term success and clinical products. This review focuses on the techniques that have been developed for characterizing the hierarchical structures of sol-gel glasses and hybrids, from atomicscale amorphous networks, through the covalent bonding between components in hybrids and nanoporosity, to quantifying open macroporous networks of the scaffolds. Methods for non-destructive in situ monitoring of degradation and bioactivity mechanisms of the materials are also included.

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Section: (C) Atomic Structure Of Sol-gel-derived Bioactive Glassmentioning

confidence: 99%

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Martin

Sheng

Hanna

et al. 2012

Phil. Trans. R. Soc. A.

122

106

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“…This is one of the most sensitive techniques available, allowing the detection of traces (ppm) of elements sputtered from atom-thick surface layers; additionally, composition depth profiles can be obtained, as well as maps with micron or even nano-scale feature resolution (nanoSIMS). Although TOF-SIMS has been used since the 1990s to characterize surface features of silicate-based glasses and hydroxyapatite, to the best of our knowledge, this technique has been used only once in the silicate bioceramic literature-as a support tool to analyse compositional inhomogeneity in sol-gel SiO 2 -CaO bioactive glasses [103]. However, TOF-SIMS has proved to generate incredibly detailed information when applied to biomaterials.…”

Section: (A) Time-of-flight Secondary Ion Mass Spectrometrymentioning

confidence: 99%

Surface characterization of silicate bioceramics

Cerruti

2012

Phil. Trans. R. Soc. A.

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The success of an implanted prosthetic material is determined by the early events occurring at the interface between the material and the body. These events depend on many surface properties, with the main ones including the surface's composition, porosity, roughness, topography, charge, functional groups and exposed area. This review will portray how our understanding of the surface reactivity of silicate bioceramics has emerged and evolved in the past four decades, owing to the adoption of many complementary surface characterization tools. The review is organized in sections dedicated to a specific surface property, each describing how the property influences the body's response to the material, and the tools that have been adopted to analyse it. The final section introduces the techniques that have yet to be applied extensively to silicate bioceramics, and the information that they could provide.

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“…A TEOS to water molar ratio of 12 was used in order to compare the structural data obtained here with previous reports on sol-gel bioactive glass structure evolution [26][27][28][29]. Pure silica gels were also prepared using similar protocols as a control (Li-free, 100S).…”

Section: Introductionmentioning

confidence: 99%

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

Maçon

Jacquemin

Page

et al. 2016

J Sol-Gel Sci Technol

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This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li 2 O by the sol-gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol-gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, 29 Si and 7 Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation.Graphical Abstract

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Characterisation of the inhomogeneity of sol–gel-derived SiO2–CaO bioactive glass and a strategy for its improvement

Cited by 34 publications

References 18 publications

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Characterizing the hierarchical structures of bioactive sol–gel silicate glass and hybrid scaffolds for bone regeneration

Surface characterization of silicate bioceramics

Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships

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