Characterisation of pregnancy losses after embryo transfer by measuring plasma progesterone and bovine pregnancy-associated glycoprotein-1 concentrations

Breukelman, S. P.; Perényi, Z.; Taverne, M.A.M.; Jonker, Herman; Weijden, G.C. van der; Vos, P.L.A.M.; Ruigh, L. de; Dieleman, S.J.; Beckers, J. F.; Szenci, O.

doi:10.1016/j.tvjl.2012.02.020

Cited by 49 publications

(39 citation statements)

References 34 publications

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“…In the preceding studies, all cows were assessed by ultrasound to have a normal embryo with a heartbeat on day 28 of gestation. Similar results have been reported in dairy cows (Humblot et al 1988, Breukelman et al 2012 and sheep (Wallace et al 1997). Collectively, these data suggest that measurement of circulating PAGs in ruminant ungulates may serve as a useful animal management tool for identifying pregnant animals that are likely to undergo loss of the fetus.…”

Section: Pags As Circulating Markers To Study Placental Function and supporting

confidence: 84%

Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy

et al. 2015

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Pregnancy-associated glycoproteins (PAGs) are abundantly expressed products of the placenta of species within the Cetartiodactyla order (even-toed ungulates). They are restricted to this order and they are particularly numerous in the Bovidae. The PAGs exhibit a range of temporal and spatial expression patterns by the placental trophoblasts and probably represent a group of related proteins that perform a range of distinct functions in the epitheliochorial and synepitheliochorial placental forms. This review presents an overview of the origins of the PAGs, a summary of PAG expression patterns, and their use as markers of pregnancy status. Speculations about their putative role(s) in pregnancy are also presented.Reproduction (2015) 149 R115-R126

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Section: Pags As Circulating Markers To Study Placental Function and supporting

confidence: 84%

Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy

et al. 2015

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“…In the preceding study, embryos at day 28, in both the embryonic mortality and embryonic maintenance groups, had viable heartbeats, suggesting that on day 28 all embryos were viable in both groups based on ultrasound. There have been similar reports on circulating PAG concentrations and embryonic mortality in lactating dairy cattle (Humblot et al 1988 ;Thompson et al 2010 ;Breukelman et al 2012 ) and sheep (Wallace et al 1997 ). Collectively, these data suggest that measurement of circulating PAGs in ruminant ungulates may serve as a useful animal management tool for identifying pregnant animals that are likely to undergo loss of the fetus.…”

Section: Postimplantation Embryo Viabilitysupporting

confidence: 57%

Predicting Embryo Presence and Viability

Pohler

Green

Geary

et al. 2015

Regulation of Implantation and Establishment of Pregnancy in Mammals

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Pregnancy establishment, followed by birth of live offspring, is essential to all mammals. The biological processes leading up to pregnancy establishment, maintenance, and birth are complex and dependent on the coordinated timing of a series of events at the molecular, cellular, and physiological level. The ability to ovulate a competent oocyte, which is capable of undergoing fertilization, is only the initial step in achieving a successful pregnancy. Once fertilization has occurred and early embryonic development is initiated, early pregnancy detection is critical to provide proper prenatal care (humans) or appropriate management (domestic livestock). However, the simple presence of an embryo, early in gestation, does not guarantee the birth of a live offspring. Pregnancy loss (embryonic mortality, spontaneous abortions, etc.) has been well documented in all mammals, especially in humans and domestic livestock species, and is a major cause of reproductive loss. It has been estimated that only about 25-30% of all fertilized oocytes in humans result in birth of a live offspring; however, identifying the embryos that will not survive to parturition has not been an easy task. Therefore, investigators have focused the identification of products in maternal circulation that permit the detection of an embryo and assessment of its well-being. This review will focus on the advances in predicting embryonic presence and viability, in vivo.

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“…Therefore, these glycoproteins have been used as a marker of pregnancy and feto-placental well-being in cattle (Breukelman et al, 2012). Radioimmunoassays (RIA) for bPSPB or bPAG-1 have a high sensitivity (95-100%) for identifying pregnant cattle from Day 30 after breeding onwards.…”

Section: Introduction Q2mentioning

confidence: 99%

Comparison of a commercial bovine pregnancy-associated glycoprotein ELISA test and a pregnancy-associated glycoprotein radiomimmunoassay test for early pregnancy diagnosis in dairy cattle

Karen

Sousa

Beckers

et al. 2015

Animal Reproduction Science

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Characterisation of pregnancy losses after embryo transfer by measuring plasma progesterone and bovine pregnancy-associated glycoprotein-1 concentrations

Cited by 49 publications

References 34 publications

Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy

Placental PAGs: gene origins, expression patterns, and use as markers of pregnancy

Predicting Embryo Presence and Viability

Comparison of a commercial bovine pregnancy-associated glycoprotein ELISA test and a pregnancy-associated glycoprotein radiomimmunoassay test for early pregnancy diagnosis in dairy cattle

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