Characterisation of aggression in Huntington's disease: rates, types and antecedents in an inpatient rehabilitation setting

Brown, Anahita; Sewell, Katherine; Fisher, Caroline A.

doi:10.1111/jocn.13614

Cited by 6 publications

(4 citation statements)

References 36 publications

(61 reference statements)

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“…The second phase of Walker and Avents [6] framework is to determine the purpose of the analysis. The need for a concept analysis has been noticed by the first author since completing prior research in sensory modulation [16][17][18][19]. During the literature reviews for these previous publications, it was noted that definitions of sensory modulation varied.…”

Section: Methodsmentioning

confidence: 99%

Defining sensory modulation: A review of the concept and a contemporary definition for application by occupational therapists

Brown

Tse

Fortune

2018

Scandinavian Journal of Occupational Therapy

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Background: Sensory interventions are prevalent amongst adult mental health practitioners and are supported by major stakeholders and policy makers across the world. The term commonly used by occupational therapists applying sensory practices is sensory modulation, however this term has evolved. Aims: This paper aims to investigate and clarify the definition of 'sensory modulation' for application by occupational therapists. Method: A framework guided this concept analysis on sensory modulation. A summative content analysis approach was employed to code results. Results: Six conceptual themes for sensory modulation were identified. 81% of authors defined sensory modulation as consisting of more than one of these themes. 18% of authors defined sensory modulation as both a neurophysiological process and means to regulate behaviour. Conclusion: The concept of sensory modulation has evolved in occupational therapy practice. The authors summarise with the following proposed definition of sensory modulation for contemporary occupational therapy practice: 'Sensory modulation is considered a twofold process. It originates in the central nervous system as the neurological ability to regulate and process sensory stimuli; this subsequently offers the individual an opportunity to respond behaviourally to the stimulus'. Significance: A contemporary definition of 'sensory modulation' has been identified for occupational therapy practice.

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Section: Methodsmentioning

confidence: 99%

Defining sensory modulation: A review of the concept and a contemporary definition for application by occupational therapists

Brown

Tse

Fortune

2018

Scandinavian Journal of Occupational Therapy

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“…Also, HD is strongly associated with behavioral disturbances such as aggression (Brown, Sewell, & Fisher, ; Fisher, Sewell, Brown, & Churchyard, ) and numerous lines of evidence indicate that OS is associated with aggression. Elevated levels of OS has been found to be linked with intermittent explosive disorder and aggression (Coccaro, Lee, & Gozal, ).…”

Section: Oxidative Stress and Mitochondria Dysfunction In Hdmentioning

confidence: 99%

Towards a comprehensive understanding of the contributions of mitochondrial dysfunction and oxidative stress in the pathogenesis and pathophysiology of Huntington's disease

Tobore

2019

J of Neuroscience Research

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Huntington's disease (HD) is a rare autosomal dominant disorder affecting the corticostriatal area of the brain. HD is driven by elongated cytosine-adenine-guanine (CAG) repeat (36 repeats or more) on the short arm of chromosome 4p16.3 in the Huntingtin gene (HTTg) which encode the huntingtin protein (HTT). Although the polyglutamine expansion within HTT is the causative factor in the pathogenesis of HD, the underlying mechanisms that provoke this expansion and the resulting neurodegeneration and clinical symptoms are not fully understood. In this paper, the critical role played by mitochondria dysfunction and oxidative stress in HTT expansion, HD progression, and clinical symptoms are elucidated. Their interactions with the key factors in the disease, as well as treatment strategies, are discussed.

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“…These symptoms have been accompanied by neurodegeneration along with an abnormal level of neurotransmitters, microglial activation, reactive astrogliosis, and impaired neurogenesis [ 15 ]. Recently, HD patients have also been characterised with different types of behavioural, motor, and aggressive symptoms [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Further, abnormalities in energy metabolism caused by mitochondrial dysfunctions add to severity of the disease. The loss of muscle function in the mandibular regions, pharynx, and oesophagus could lead to disorders like bruxism (grinding the teeth), failure to intake of food and choking, which could ultimately lead to death [ 16 , 18 ]. Currently, there are no available treatments that can delay the onset or arrest the progression of the disease, while the focus of medical care is limited to merely managing the neurological symptoms of HD.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease

Velusamy

Panneerselvam

Purushottam

et al. 2017

Oxidative Medicine and Cellular Longevity

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Huntington's disease (HD) is characterised by movement disorders, cognitive impairments, and psychiatric problems. The abnormal generation of reactive oxygen species and the resulting oxidative stress-induced mitochondrial damage in neurons upon CAG mutations in the HTT gene have been hypothesized as the contributing factors of neurodegeneration in HD. The potential use of antioxidants against free radical toxicity has been an emerging field in the management of ageing and many neurodegenerative disorders. Neural stem cells derived adult neurogenesis represents the regenerative capacity of the adult brain. The process of adult neurogenesis has been implicated in the cognitive functions of the brain and is highly modulated positively by different factors including antioxidants. The supportive role of antioxidants to reduce the severity of HD via promoting the functional neurogenesis and neuroprotection in the pathological adult brain has great promise. This review comprehends the recent studies describing the therapeutic roles of antioxidants in HD and other neurologic disorders and highlights the scope of using antioxidants to promote adult neurogenesis in HD. It also advocates a new line of research to delineate the mechanisms by which antioxidants promote adult neurogenesis in HD.

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Characterisation of aggression in Huntington's disease: rates, types and antecedents in an inpatient rehabilitation setting

Abstract: Rates of aggression in Huntington's disease inpatients can be high. Knowledge of potential triggers, such as personal care, is important for nursing and care staff, so that attempts can be made to minimise distress for patients and maximise the personal safety of care staff.

Cited by 6 publications

References 36 publications

Defining sensory modulation: A review of the concept and a contemporary definition for application by occupational therapists

Defining sensory modulation: A review of the concept and a contemporary definition for application by occupational therapists

Towards a comprehensive understanding of the contributions of mitochondrial dysfunction and oxidative stress in the pathogenesis and pathophysiology of Huntington's disease

Protective Effect of Antioxidants on Neuronal Dysfunction and Plasticity in Huntington’s Disease

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