Characterisation and outcomes of adult patients with paracetamol overdose presenting to a tertiary hospital in Singapore

Tan, Christina; Sklar, Grant E.

doi:10.11622/smedj.2016170

Cited by 13 publications

(24 citation statements)

References 33 publications

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“…Последние рекомендации (2019) предлагают инфузии ацетилцистеина проводить в два этапа: 200 мг/кг в течение 4 ч, затем 100 мг/кг в течение 16 ч [14]. Препарат обладает высокой антидотной эффективностью, но при введении у 8-24,4% наблюдается анафилактоидная реакция [23,24].…”

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“…В Исландии с ним связаны 18% всех отравлений лекарственными препаратами [27]. Парацетамол является наиболее распространённым фармацевтическим агентом, вовлечённым в токсическое воздействие в Сингапуре [24].…”

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“…Recent recommendations (2019) suggest that acetylcysteine infusions should be carried out in two stages: 200 mg / kg for 4 hours, then 100 mg / kg for 16 hours [14]. The drug has high antidote efficacy, but when administered, an anaphylactoid reaction is observed in 8-24.4% [23,24].…”

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confidence: 99%

“…In Iceland, 18% of all drug poisoning are associated with it [27]. Paracetamol is the most common pharmaceutical agent involved in toxic effects in Singapore [24]. [30] 37,6 Ирландия / Iceland [31] 30 Канада / Canada [32] 30 Австралия / Australia [33] 28 США / USA [34] 10,9 Чили / Chile [35] 6,8 Россия / Russia ?…”

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confidence: 99%

“…2), то доля преднамеренных самоотравлений с участием препарата значительно выше -от 47,8 до 90%, а в отдельных регионах, социальных или возрастных группах может приближаться практически к 100%. Table 2 Доля преднамеренных самоотравлений при передозировке парацетамола, % / The proportion of intentional self-poisoning in case of an overdose of Paracetamol, % Страна / Сountry % Австралия / Australia [23,26] 85-90 Швеция / Sweden [36] 85 Швейцария / Switzerland [37] 79 Сингапур / Singapore [24] 76,8 Польша / Poland [38] 68,2 Испания / Spain [39] 47,8 Россия / Russia [21] 60* Беларусь / Belarus [40] 78,6* *Для всех отравлений медикаментами / *for all drug poisonings Например, в Австралии лишь 0,02% подростков сообщали о случайном супратерапевтическом приёме парацетамола [25].…”

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Парацетамол Среди Средств Суицидальных Действий В России И Зарубежом

Зотов¹,

Борисович²,

Рафаиловна³

et al. 2019

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Парацетамол Среди Средств Суицидальных Действий В России И Зарубежом

Зотов¹,

Борисович²,

Рафаиловна³

et al. 2019

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Boldine treatment protects acetaminophen‐induced liver inflammation and acute hepatic necrosis in mice

Ezhilarasan

Raghunandhakumar

2021

J Biochem & Molecular Tox

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Drug‐induced liver injury (DILI) is a frequent cause responsible for acute liver failure (ALF). Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI. At high doses, APAP causes acute liver necrosis and responsible for ALF and liver transplant cases in 50% and 20% of patients, respectively, in the United States alone. Oxidative stress and glutathione depletion are implicated in APAP‐induced liver necrosis. Boldine, a plant‐derived compound is shown to have promising antioxidant potential. Therefore, this study investigates the protective effect of boldine against APAP‐induced acute hepatic necrosis in mice. A single toxic dose of APAP (300 mg/kg b.w. p.o.) was administered in overnight‐fasted mice to induce acute liver necrosis. Separately, APAP + boldine and APAP + N‐acetylcysteine (NAC) simultaneous treatments were also given. Serum transaminases and reduced glutathione, enzymic antioxidants, tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), and, IL‐6 were evaluated in liver tissue. Acute APAP intoxication significantly elevated serum marker enzymes of hepatotoxicity. APAP administration increased lipid peroxidation, TNF‐α, IL‐1β, and IL‐6 protein expressions. The enzymic antioxidants and reduced glutathione levels were decreased in liver tissue of APAP intoxicated mice. Boldine and NAC simultaneous treatments prevented APAP‐induced oxidative stress, inflammation, and necrosis. The results of this study suggest the crucial role of boldine to protect against APAP induced hepatotoxicity by virtue of its antioxidant and anti‐inflammatory properties.

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Paracetamol overdose

2018

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Characterisation and outcomes of adult patients with paracetamol overdose presenting to a tertiary hospital in Singapore

Cited by 13 publications

References 33 publications

Парацетамол Среди Средств Суицидальных Действий В России И Зарубежом

Парацетамол Среди Средств Суицидальных Действий В России И Зарубежом

Boldine treatment protects acetaminophen‐induced liver inflammation and acute hepatic necrosis in mice

Paracetamol overdose

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