Characterisation and modelling of the elastic properties of poly(lactic acid) nanofibre scaffolds

Gómez-Pachón, Edwin Yesid; Sánchez-Arévalo, Francisco M.; Sabina, Federico J.; Maciel-Cerda, Alfredo; Campos, Raúl Montiel; Batina, Nikola; Morales-Reyes, Israel; Vera‐Graziano, Ricardo

doi:10.1007/s10853-013-7644-7

Cited by 27 publications

(19 citation statements)

References 39 publications

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“…Analysis of PLAN nanofibers (Figure a) shows that nanoparticles are homogeneously dispersed, whereas for PLAA (Figure [b‐c]), nanoparticles were pulled onto the nanofiber surface, with their size matching closely to MGCSNs. Electrospinning leads to rapid solidification which inhibits the crystallization of polymers, as a result of which no evidence of extensive crystallization is observed for all PLA based electrospun scaffolds showing very identical diffraction patterns . XRD diffractogram of PLA (Figure d) appears as an amorphous hump with small peaks at 16.7° (110/200), 19.1° (203), 22.3°(015) and 15.1°(010), the first three peaks corresponds to α‐crystalline form of PLA and last peak corresponds to the β‐form of PLA .…”

Section: Resultsmentioning

confidence: 99%

Silk nano‐discs: A natural material for cancer therapy

et al. 2018

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The article demonstrates the crystalline silk nano‐discs (CSNs), with well‐controlled morphology, which upon magnetization, yields magnetic crystalline silk nano‐discs, making both prominent alternatives for replacing metal templates such as gold, silver, and so on in therapeutics and implants. The isolated β‐sheet‐rich discotic CSNs have ~50 nm diameter, high crystallinity (> 90%), and are insoluble but provide good dispersibility and stability in aqueous solutions. The melt blending‐cum‐electrospinning of functionalized CSN with poly(lactic acid) results in biocompatible nanofiber‐based scaffolds having in vitro cell cytocompatibility with improved cell adhesion and proliferation. The assessment of release behavior of curcumin, a naturally occurring anticancer drug, shows sustained release over 25 days exhibiting effective cytotoxicity against human cervical cancer cells. Further, combined effect of curcumin and hyperthermia reduced the cell growth by ~63%. Alignment of CSN‐derived magnetic nanoparticles due to effective fiber drawing process during electrospinning could improve cytocompatibility against BHK‐21 cells, and therefore efficacy for cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Silk nano‐discs: A natural material for cancer therapy

et al. 2018

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“…En la figura 7 (c) se observa la estructura coraza/núcleo (core/shell) donde en el interior de la fibra (núcleo) el CS con fármaco se deposita en forma de fibra, se comparó con el estudio hecho por Gómez et al [47]. En la figura 7 (d) las fibras presentan incrustaciones de CS con fármaco sobre la superficie (coraza) esto se pudo haber dado debido a que la PCL es hidrofóbica y el CS es hidrofílico y su inmiscibilidad hace que el polímero de CS con TC se adhiera a la superficie de la fibra en forma de incrustaciones.…”

Section: Microscopía Electrónica De Transmisión (Tem) Y Microscopía Dunclassified

Preparación y caracterización de membranas poliméricas electrohiladas de policaprolactona y quitosano para la liberación controlada de clorhidrato de tiamina / Preparation and Characterization of Electrospun Polymeric Membranes of Polycaprolactone and Chitosan for Controlled Release of Thiamine Chlorhydrate

Cepeda

2016

Cienc. En Desarro.

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ResumenActualmente existen importantes investigaciones sobre la preparación de membranas porosas bioabsorbibles que permiten la liberación controlada de fármacos y vitaminas. En este estudio se propuso preparar membranas porosas a partir de policaprolactona (PCL) y quitosano (CS) bajo la técnica de electrohilado aplicando diferentes parámetros con el fin de evaluar sus características internas y propiedades para una potencial aplicación como liberador del clorhidrato de tiamina (Vitamina B 1 ). Además se desarrolló el estudio de la cinética de liberación In vitro del clorhidrato de tiamina (TC) con las membranas preparadas. Se obtuvo una membrana polimérica a partir de una disolución de

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“…PLA is also biocompatible and resorbable so that it finds increasing applications in the medical sector for controlled drug delivery [5] and tissue engineering [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Plasticizing effect of biobased epoxidized fatty acid esters on mechanical and thermal properties of poly(lactic acid)

et al. 2016

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Poly(lactic acid)-PLA is a polyester that can be produced from lactic acid derived from renewable resources. This polymer offers attracting uses in packaging industry due to its biodegradability and high tensile strength. However, PLA is quite brittle, which limits its applications. To overcome this drawback, PLA was plasticized with epoxy-type plasticizer derived from a fatty acid, octyl epoxy stearate (OES) at different loading (1, 3, 5, 10, 15 and 20 phr). The addition of OES decreases the glass transition temperature and provides a remarkable increase in elongation at break and impact absorbed energy.Plasticizer saturation occurs at relatively low concentrations of about 5 phr OES; higher concentration leads to phase separation as observed by field emission scanning electron microscopy (FESEM). Optimum balanced mechanical properties are obtained at relatively low concentrations of OES (5 phr) thus indicating the usefulness of this material as environmentally friendly plasticizer for PLA industrial formulations.

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Characterisation and modelling of the elastic properties of poly(lactic acid) nanofibre scaffolds

Cited by 27 publications

References 39 publications

Silk nano‐discs: A natural material for cancer therapy

Silk nano‐discs: A natural material for cancer therapy

Plasticizing effect of biobased epoxidized fatty acid esters on mechanical and thermal properties of poly(lactic acid)

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