Preparación y caracterización de membranas poliméricas electrohiladas de policaprolactona y quitosano para la liberación controlada de clorhidrato de tiamina / Preparation and Characterization of Electrospun Polymeric Membranes of Polycaprolactone and Chitosan for Controlled Release of Thiamine Chlorhydrate

Abstract

ResumenActualmente existen importantes investigaciones sobre la preparación de membranas porosas bioabsorbibles que permiten la liberación controlada de fármacos y vitaminas. En este estudio se propuso preparar membranas porosas a partir de policaprolactona (PCL) y quitosano (CS) bajo la técnica de electrohilado aplicando diferentes parámetros con el fin de evaluar sus características internas y propiedades para una potencial aplicación como liberador del clorhidrato de tiamina (Vitamina B 1 ). Además se desarrolló el estudio de la cinética de liberación In vitro del clorhidrato de tiamina (TC) con las membranas preparadas. Se obtuvo una membrana polimérica a partir de una disolución de

Obtention of Cellulose Acetate Nanofibers From Sugar Cane Bagasse

“…In figure 2, SEM micrographs seen at 1000x and 10000x; we see that the nanofibers from the SCB cellulose acetate are of a uniform, cylindrical structure; while drops in the fibers (clusters) can be seen in the Aldrich cellulose nanofibers: this is mainly due to the lower flow rate of the injector pumping the polymer with the BCA cellulose acetate when compared with Aldrich's; This could lead to the conclusion that a lower flow rate results in thinner fibers, and this is comparable with what is observed in the literature [16][17][18][19][20].…”

The Effect of Electrospun Polycaprolactone Nonwovens Containing Chitosan and Propolis Extracts on Fresh Pork Packaged in Linear Low-Density Polyethylene Films

“…In addition, the low differences in the refractive indices between fiber-air versus fiber-liquid of the composite within the free volume might have caused the film to become translucent [52]. As reported by Sánchez et al [53], the moisture absorption of the polycaprolactone fibers can lower their glass transition temperature below the test temperature. The plasticization phenomenon might have also improved the flexibility of the coatings, thereby preventing them from breaking during the testing conducted in this study (i.e., pork chop application).…”

“…Purge loss in CON reached the highest statistical level on day 4 of storage, while the highest statistical level for purge loss was observed on day 8 and day 16 for Film 1 and Film 2, respectively. The delay in purge loss thresholds for Film 1 and Film 2 samples may have been caused by the ultra-thin diameter of the polycaprolactone/chitosan electrospun fibers, which produces a smaller liquid-fiber contact area and subsequently increases the air-contact area [53]. On the other hand, the presence of PE in the nonwovens can reduce the hydrophilic nature of chitosan [36], which might have allowed for increased moisture retention in the pork chops.…”

Ultrathin single and multiple layer electrospun fibrous membranes of polycaprolactone and polysaccharides

“…[14][15][16] Various studies have been carried out on the preparation of nanofibers with PCL, and it has been indicated that they exhibit outstanding functionalities for the fabrication of scaffolds and in food packaging applications. [16][17][18][19] Although there are fewer reports on the electrospinning of βglucan 20,21 and modified starches, the latter have been highlighted for biomedical and pharmaceutical applications. 22,23 The objective of this study was to evaluate the feasibility of obtaining ultrathin membranes via electrospinning, from biodegradable polymers: PCL, pullulan, mixtures of PCL with non-water-soluble polysaccharides (PCL/β-glucan and PCL/PMS), and, subsequently, to evaluate their physical-chemical characteristics to determine which membranes would have potential use for future application as systems for encapsulation and release of active compounds.…”