Character and Specifics of the Structural Alteration of the Parenchyma and Bloodstream of the Testes of White Rats With Prolonged Administration of High Doses of Prednisolone

Abstract

The aim: To investigate the nature of morphofunctional changes in the parenchyma and bloodstream of the testes of white rats with prolonged administration of high doses of prednisolone. Material and methods: The experiments were performed on rats fed daily for 1, 3, 7, 14 and 28 days. prednisolone was administered intramuscularly at a rate of 0.4 mg / kg. Massometric, organometric, histological and morphometric studies were performed. Results: Administration of high doses of prednisolone resulted in a significant increase in body weight and testicular weight and volume. As the drug was administered, spermatogenesis was activated. The number of immature forms of germ cells increased significantly. At the same time, the specific number of mature forms of sperm decreased. This led to a significant increase in the diameter of the convoluted tubules, the thickness of the spermatogenic epithelium, as well as the index of spermatogenesis. The increase in indicators was especially intense until the 7th day of observation, after which its rate decreased, although the dynamics remained unchanged. The thickness of the protein shell tended to decrease. The detected changes occurred against the background of dilation and plethora of arteries, especially up to 7-14 days of the experiment, after which their intensity decreased slightly. This was accompanied by a simultaneous reversible narrowing of the lumen of small arteries and arterioles. Conclusion: Thus, long-term administration of high doses of prednisolone promotes the activation of spermatogenesis with an increase in immature forms of germ cells and a simultaneous decrease in the proportion of mature sperm. Increased vascular blood supply, especially in the early period. In the long run, the capacity of small arteries and arterioles is reduced, as well as the degree of activation of spermatogenesis.

The Effect of Prolonged Administration of Dexamethasone in High Doses on the Structural Organization of Kidneys and Their Blood Vessels Bed in White Rats

“…The mineralocorticoid effect of dexamethasone contributes to salt and water retention in the body, which in turn can lead to the development of arterial hypertension. The development of arteritis, which is characteristic in such cases, may play a potentiating role [10,11,12]. The logical consequence of this is the increase in wall tone observed in our experimental studies with simultaneous narrowing of the lumen of the arcuate and lobular arteries and arterioles, which subsequently leads to a decrease in their throughput and impaired renal tubular epithelial trophism.…”

“…Мінералокортикоїдна дія дексаметазону сприяє затримці солей і води в організмі, що в свою чергу може привести до розвитку артеріальної гіпертензії. Потенціюючу роль при цьому може відіграти характерний у таких випадках розвиток артеріїту [10,11,12]. Логічним наслідком цього є зафіксоване у наших експериментальних дослідженнях підвищення тонусу стінок із одночасним звуження просвіту дугових та часточкових артерій і артеріол, що у подальшому приводить до зниження їх пропускної здатності і порушення трофіки епітелію ниркових канальців.…”

The structural rearrangement of testicular arteries in case of chronic ethanol intoxication

“…At the same time, the degree of remodeling of the stu died vessels dominates in the left testicle. A more pronounced structural rearrangement of the vessels of the left testicle is probably explained by the anatomical features of the blood supply of the studied organ [13].…”

“…O.M. Herman et al [13] studied the structural damage of the parenchyma and blood flow disorders in the testes of white rats during long-term exposure to high doses of prednisolone. They established the thickening of the arterial wall and the reduction of the lumen, which was complicated by a marked violation of hemodynamics in the examined organ.…”

Lead Exposure Assessment and Its Impact on the Structural Organization and Morphological Peculiarities of Rat Ovaries

“…The reproductive system of both males and females is also affected by lead [ 13 , 15 , 31 , 34 , 35 , 36 , 37 ]. It specifically affects the condition of the ovaries in complexways.…”