Chapter 5.4 Five-membered ring systems: With more than one N atom

Walters, Michael A.; Vargas, J. Ramón

doi:10.1016/s0959-6380(97)80010-4

Cited by 2 publications

(4 citation statements)

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“…The chemical structures and other details of the above synthesized derivatives confirmed by physical properties and spectral data are listed in table-1 meanwhile, figure-2 demonstrates the FT-IR spectra of compound (1) with absorption bends at ( 3432-3326)cm -1 . In figure-3 the FT-IR spectra of compound (5) showed appearance absorption bends at (3277)cm -1 .…”

Section: Resultsmentioning

confidence: 89%

“…New thiazolidine-5-one was prepared as shown in scheme-1 (Fig. 6) which indicates the H 1 -NMR for compound-3, p-chlorobenzoic acid with thiosemicarbazide to produce (1). Treated (1) with p-tolualdehyde had given-2, followed by refluxing-2 with mercaptoaceticacid in dry benzene afforded thiazolidine -4-one (compound-3).…”

Section: Fig 5: Ft-ir Spectrum Of Compound-10mentioning

confidence: 99%

“…It involves design and processes of chemical products that reduce or eliminate the use or generation of hazardous substances. The fused and pendent 1,2,4-triazoles are a ubiquitous feature of many pharmaceutical and agrochemical products [1][2][3]. Heterocyclic compounds are cyclic compounds with the ring containing carbon and other element i.e.…”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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Synthesis of some new heterocyclic derivatives from aromatic carbonyl compounds and assessment of their antimicrobial activity

2023

JPTCP

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This research work involves synthesis of 18 heterogeneous tetra, penta lateral cyclic compounds (1,3,1,2, Carbothioamide; Thiazole-4-one; Azetidin-2one; Oxazol) compounds. The thiazolidine-4-one was prepared by reaction of p-chlorobenzoic acid with thiosemicarbazide to yield the compound-1, which was treated with p-tolualdehyde to produce compound-2 followed by refluxing (2) with mercaptoacetic acid in dry benzene to yield thiazolidine-4-one compound (3). The reaction of p-nitro benzoic acid with ethanol in the presence of sulphonic acid yielded compound-4 and the reaction of ( 4) with thiosemicarbazide and 4% NaOH led to produce ring closure giving rise to 1,2,4-triazole (6). The thiosemicarbazone was prepared by the reaction of thiosemicarbazide with different aldehyde (7-9) compounds, A2-substituted -1,3-thiazolidine-4-one were synthesized by the reaction of thiosemicarbazone with chloroacetic acid in the presence of anhydrous sodium acetate yielded (10-12) compounds. The compound-15 was made by the reaction of p-amino benzoic acid with ethyl chloroacetate produced compound-13, then treated with urea to obtain the compound-14 followed by 4-phenyl phenacyl bromide to prepare compound-15. The 2azetidinone derivative was synthesized by many steps started from cyclization of p-bromoacetophenon with urea in iodine to yield compound-16 which was reacted with p-bromobenzaldehyde to yield compound-17. Schiff base has been treated with chloroacetyl chloride in the presence of catalytic amount of tri-ethyl amine to produce compound-18. All the synthesized compounds were characterized spectroscopically by both FT-IR spectroscopy and by H1-NMR, and C13-NMR for others. Almost all showed matching features and the validity of the proposed structure. The following synthesized compounds (2,3,6,11,13,15,17,18) were also tested against two types of bacteria (Staphylococcus aureus and Escherichia coli and fungus Candida albicans where they showed potential antibacterial and antifungal activities, respectively.

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Section: Resultsmentioning

confidence: 89%

Section: Fig 5: Ft-ir Spectrum Of Compound-10mentioning

confidence: 99%