Chapter 4 The distribution of corticotropin-releasing factor (CRF), CRF binding sites and CRF1 receptor mRNA in the mouse cerebellum

King, James S.; Madtes, Paul; Bishop, Georgia A.; Overbeck, T.

doi:10.1016/s0079-6123(08)63358-0

Cited by 43 publications

(18 citation statements)

References 30 publications

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“…ZII is not, however, the only antigen that reveals parasagittal bands in the cerebellar cortex. Over 20 different molecules yield a striped pattern in mammalian cerebella including 5 0 -nucleotidase (Scott, 1963), acetylcholinesterase (Marani and Voogd, 1977), corticotropin-releasing factor (King et al, 1997), heat shock protein 25 (Armstrong et al, 2001), human natural killer cell antigen (Eisenman and Hawkes, 1993;Marzban et al, 2004) cadherins (Arndt and Redies, 1998;Vanhalst et al, 2005;Neudert and Redies, 2008) and phospholipase Cb4 (PLCb4, Sarna et al, 2006;Marzban et al, 2007). In order to gain a better understanding of how the cerebellar cortex is organized in birds as well as the correspondence between ZII and other antigens, we also examined the pattern of PLCb4 labeling throughout the hummingbird cerebellum.…”

Section: Introductionmentioning

confidence: 99%

Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase Cβ4

Iwaniuk

Marzban

Pakan

et al. 2009

Journal of Chemical Neuroanatomy

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Section: Introductionmentioning

confidence: 99%

Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase Cβ4

Iwaniuk

Marzban

Pakan

et al. 2009

Journal of Chemical Neuroanatomy

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“…The majority of the nonfunctional splice variants are found only in humans and all are deficient in ligand binding and/or signaling properties (Dautzenberg et al 2001). In situ hybridization and immunohistochemical studies have localized the mRNA for CRF-R1 or the peptide itself in the rodent's cerebellum (Chen et al 1986(Chen et al , 2000Chai et al 1990;De Souza and Insel 1990;Potter et al 1994;King et al 1997;Primus et al 1997;Bishop et al 2000). In the mouse cerebellum (Bishop et al 2000), CRF-R1 immunoreactivity is present on the somas and primary dendrites of most, if not all, Purkinje cells, as well as on radial glial cells, and scattered granule cells.…”

Section: Crf Receptors In the Cerebellummentioning

confidence: 99%

Modulatory Role of Neuropeptides in the Cerebellum

Bishop¹,

King²

2013

Handbook of the Cerebellum and Cerebellar Disorders

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The existence of neuropeptides in the central nervous system has been known for almost 40 years. Within the cerebellum approximately 22 neuropeptides have been identified. However, the functional role(s) for many of the different peptides in the cerebellum is largely unknown as their distribution in the cerebellum is not uniform and varies between species. Further, to date sufficient physiological analysis has not been carried out to determine the potential importance of cerebellar peptides. It has been proposed that peptides slowly modulate cerebellar circuits by acting through G protein-coupled receptors in contrast to the fast action of amino acid neurotransmitters that bind to ionotropic receptors. This effect, in turn, would influence the state of an entire neuronal circuit rather than a single neuron. This chapter will be focused on two members of the corticotropin-releasing factor (CRF) family of peptides, namely, corticotropin-releasing factor and urocortin because their distribution has been described in multiple species and their function has been investigated to a greater extent than any of the other peptides found in the cerebellum. A review of the distribution of these peptides as well as a discussion of their cognate receptors is included. Data on the functional role of both peptides is presented. It is clear that complex interactions take place between these peptides and other transmitters in the cerebellum. The physiological data suggest that CRF is essential for normal cerebellar-mediated motor performance. There is less data on the physiological role of urocortin (UCN) in the cerebellum. To date, it has been shown that UCN increases the spontaneous firing rate

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“…The peptide is found in neocortex and in limbic regions including central nucleus of the amygdala, dorsal and ventral part of the bed nucleus of the stria terminalis and hippocampus. High densities of CRHimmunoreactive neurons reside in locus coeruleus, dorsal and median raphe, periaqueductal gray, nucleus of the solitary tract and cerebellar complex (Merchenthaler et al, 1982;Swanson et al, 1983;Sawchenko and Swanson, 1985;Sakanaka et al, 1987;Koegler-Muly et al, 1993;Van Bockstaele et al, 1996;King et al, 1997;Morin et al, 1999;Chen et al, 2004b). Here we focus on the distribution and function of CRH and its receptors, CRF 1 receptor and CRF 2 receptor, in selected regions including the hypothalamic paraventricular nucleus, hippocampal formation and amygdala nuclei.…”

Section: Crh Neuroanatomymentioning

confidence: 99%

“…Several groups have demonstrated release of endogenous CRH from neurons within amygdala (Merali et al, 1998;Herringa et al, 2006) hippocampus (Chen et al, 2004b(Chen et al, , 2006a, locus coeruleus (Curtis and Valentino, 1994;Kirby et al, 2000) and cerebellum (King et al, 1997). However, much remains to be determined about the nature of the endogenous CRH-CRH receptor unit: how is the peptide released?…”

Section: Introductionmentioning

confidence: 99%

The central corticotropin releasing factor system during development and adulthood

Kőrösi

Baram

2008

European Journal of Pharmacology

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Corticotropin releasing factor (CRH) has been shown to contribute critically to molecular and neuroendocrine responses to stress during both adulthood and development. This peptide and its receptors are expressed in the hypothalamus, as well as in limbic brain areas including amygdala and hippocampus. This is consistent with roles for CRH in mediating the influence of stress on emotional behavior and cognitive function.The expression of CRH and of its receptors in hypothalamus, amygdala and hippocampus is agedependent, and is modulated by stress throughout life (including the first postnatal weeks). Uniquely during development, the cardinal influence of maternal care on the central stress response governs the levels of central CRH expression, and may alter the 'set-point' of CRH-gene sensitivity to stress in a lasting manner.

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Chapter 4 The distribution of corticotropin-releasing factor (CRF), CRF binding sites and CRF1 receptor mRNA in the mouse cerebellum

Cited by 43 publications

References 30 publications

Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase Cβ4

Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase Cβ4

Modulatory Role of Neuropeptides in the Cerebellum

The central corticotropin releasing factor system during development and adulthood

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