Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase Cβ4

Iwaniuk, Andrew N.; Marzban, Hassan; Pakan, Janelle M.P.; Watanabe, Masahiko; Hawkes, Richard; Wylie, Douglas R.

doi:10.1016/j.jchemneu.2008.10.001

Cited by 36 publications

(75 citation statements)

References 39 publications

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“…Understandably, the parasagittal organization of SC projections to the avian cerebellum has been less well understood. Furthermore, Purkinje cell compartmentation as revealed by zebrin II has been reported recently in birds [Pakan et al, 2007;Iwaniuk et al, 2009;Marzban et al, 2010]. Thus, further data on SC projections in birds are wanting.…”

Section: Introductionmentioning

confidence: 76%

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

Furue

Uchida²,

Shinozaki³

et al. 2010

Brain Behav Evol

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In birds, spinocerebellar (SC) projections to the cerebellar cortex have not been understood well. We examined SC fiber terminal fields originating from the cervical and lumbosacral enlargements (CE and LSE, respectively) in the chicken. SC fiber terminals show parasagittal bands in the granular layer. Labeled terminals from the CE were distributed primarily in folia II–V and IX. Parasagittal bands of labeled terminals from the CE were not clearly separated in folia II and III but were clearly separated in folia IV and V. In folium IX, labeled terminals were diffusely distributed in all subfolia with no evidence of banding. The numbers of bands were 5 in folium II, 12 in folium III and 7 in folia IV and V at maximum. Labeled terminals from the LSE were distributed primarily in folia II–VI and IX. Labeled terminals from the LSE were arranged in 4 bands in folium II and in 8 bands in folium III at maximum. Parasagittal bands from the LSE in folia IV and V were not clearly separated. In folium VI, the numbers of parasagittal bands was 6 at maximum. In folium IX, labeled terminals were mainly found in subfolium IXc forming 6–8 parasagittal bands. There were more parasagittal bands of labeled terminals from the CE than from the LSE. The topography of SC fiber terminals from the CE was different from that of SC fiber terminals from the LSE.

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Section: Introductionmentioning

confidence: 76%

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

Furue

Uchida²,

Shinozaki³

et al. 2010

Brain Behav Evol

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“…Other groups have subsequently studied zebrin-IIimmunoreactive cerebellar compartments in order to carry out the following investigations: (1) interspecific comparison with the tammar wallaby (Macropus eugenii) (Marzban et al 2012), microchiropteran bats (Kim et al, 2009), hummingbirds (Aves: Trochilidae) (Iwaniuk et al, 2009), chicks (Gallus domesticus) (Marzban et al, 2010), pigeons (Columba livia) (Pakan et al, 2007; for an overview, see Marzban and Hawkes, 2011); (2) visualization of aldolase C with fluorescence through gene manipulation with the help of aldolase CVenus knock-in mice to facilitate studies on cerebellar compartmentalization (Fujita et al, 2014); (3) presentation of parasagittal stripes in the vermis which, complementary to zebrin II, are immunoreactive for neurofilament H (Demilly et al, 2011); (4) identification of links between the olivocerebellar projection and zebrin-immunoreactive compartments in the laboratory mouse (Sugihara and Quy, 2007) and in marmoset (Callithrix jacchus) (Fujita et al, 2010); (5) clarification of the role played by the helix-loop-helix (HLH) transcription factor early B-cell factor 2 (EBF2) (Croci et al, 2006); and (6) evaluation of the cerebellar connectivity in spinocerebellar ataxia type 1 (Solodkin et al, 2011). The second main research area of Wolfgang Knabe and colleagues, whose roots date back to the former anatomical department of Hans-Jürg Kuhn, continued previous projects on the retina, then served as a bridge between the retina and the forebrain, and, thereafter, was successively expanded to include the entire brain, spinal cord, neural crest, and the placodes.…”

Section: Cerebellummentioning

confidence: 99%

Early development of the nervous system of the eutherian <i>Tupaia belangeri</i>

Knabe¹,

Washausen²

2015

Primate Biol.

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Abstract. The longstanding debate on the taxonomic status of Tupaia belangeri (Tupaiidae, Scandentia, Mammalia) has persisted in times of molecular biology and genetics. But way beyond that Tupaia belangeri has turned out to be a valuable and widely accepted animal model for studies in neurobiology, stress research, and virology, among other topics. It is thus a privilege to have the opportunity to provide an overview on selected aspects of neural development and neuroanatomy in Tupaia belangeri on the occasion of this special issue dedicated to Hans-Jürg Kuhn. Firstly, emphasis will be given to the optic system. We report rather "unconventional" findings on the morphogenesis of photoreceptor cells, and on the presence of capillary-contacting neurons in the tree shrew retina. Thereafter, network formation among directionally selective retinal neurons and optic chiasm development are discussed. We then address the main and accessory olfactory systems, the terminal nerve, the pituitary gland, and the cerebellum of Tupaia belangeri. Finally, we demonstrate how innovative 3-D reconstruction techniques helped to decipher and interpret so-far-undescribed, strictly spatiotemporally regulated waves of apoptosis and proliferation which pass through the early developing forebrain and eyes, midbrain and hindbrain, and through the panplacodal primordium which gives rise to all ectodermal placodes. Based on examples, this paper additionally wants to show how findings gained from the reported projects have influenced current neuroembryological and, at least partly, medical research.

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“…ZII is expressed in PCs such that there are sagittal stripes of high expression (ZIIϩ) interdigitated with stripes of little expression (ZIIϪ). The spatial pattern and number of ZII stripes is highly conserved in the cerebella of birds and mammals (Pakan et al, 2007;Iwaniuk et al, 2009;Marzban and Hawkes, 2011), indicating that ZII may be critical for cerebellar function.…”

Section: Introductionmentioning

confidence: 99%

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Graham

Wylie

2012

J. Neurosci.

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The cerebellum is a site of complex sensorimotor integration and contains up to 80% of the neurons in the brain, yet comparatively little is known about the organization of sensorimotor systems within the cerebellum. It is known that afferent projections and Purkinje cell (PC) response properties are organized into sagittal "zones" in the cerebellum. Moreover, the isoenzyme aldolase C [also known as zebrin II (ZII)] is heterogeneously expressed in cerebellar PCs such that there are sagittal stripes of PCs with high expression (ZIIϩ) interdigitated with stripes of little or no expression (ZIIϪ). In the present study, we show how the ZII stripes in folium IXcd of the vestibulocerebellum in pigeons are related to response properties of PCs. IXcd consists of seven pairs of ZIIϩ/Ϫ stripes denoted P1ϩ/Ϫ (medial) to P7ϩ/Ϫ (lateral). Electrophysiological studies have shown that vestibulocerebellar PCs respond to particular patterns of optic flow resulting from self-motion in three-dimensional space. In our study, we recorded optic flow preferences from PCs in IXcd, marked recording locations with injections of fluorescent tracer, and subsequently immunoreacted coronal sections for ZII. We found that the PCs within a ZIIϩ/Ϫ stripe pair all responded best to the same pattern of optic flow. That is, a ZIIϩ/Ϫ stripe pair forms a functional unit in the cerebellum. This is the first demonstration that the function of PCs is associated with ZII stripes across the mediolateral extent of an entire folium.

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Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase Cβ4

Cited by 36 publications

References 39 publications

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

Early development of the nervous system of the eutherian <i>Tupaia belangeri</i>

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

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Compartmentation of the cerebellar cortex of hummingbirds (Aves: Trochilidae) revealed by the expression of zebrin II and phospholipase Cβ4

Cited by 36 publications

References 39 publications

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

Spinocerebellar Projections from the Cervical and Lumbosacral Enlargements in the Chicken Spinal Cord

Early development of the nervous system of the eutherian &lt;i&gt;Tupaia belangeri&lt;/i&gt;

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

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Early development of the nervous system of the eutherian <i>Tupaia belangeri</i>