CHAPTER 3. Methods of Peroxynitrite Synthesis in the Context of the Development and Validation of Peroxynitrite Sensors

Bayachou, Mekki; Altawallbeh, Ghaith; Kalil, Haitham; Wojciechowski, Sarah; Bose, Tiyash

doi:10.1039/9781782622352-00048

Cited by 2 publications

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“…Clinical reports have shown the noxious effects of this metabolite on the cellular level, ranging from damaging DNA and the lipids of cell membranes to inflammation and reduced cardiac muscle contractions. PON is also involved in several ailments such as neurodegenerative disorders, inflammations, diabetes, cancers, and cardiovascular diseases (12)(13). Recently, PON has been added as a new member of the nitroxidative array of reactive metabolites (13).…”

Section: Introductionmentioning

confidence: 99%

Synthetic Melanin Films as Potential Interfaces for Peroxynitrite Detection and Quantification

et al. 2017

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Peroxynitrite (PON) is a highly reactive oxygen-nitrogen species that facilitates both oxidation and nitration reactions. Early reports have revealed the deleterious effects of PON on DNA, proteins, and lipids. Recent studies have suggested that melanin can act as an antioxidative therapy to scavenge the reactive oxygen-nitrogen species (RO-NS) including PON. Melanin is a natural pigment that has many physiological functions involving the neutralization of highly oxidative species. In this project, the interaction between PON and synthetic melanin has been studied. In addition, the electrochemical characteristics of the polymerized 5,6-dihydroxy indole (DHI) as a model of synthetic melanin were examined using cyclic voltammetry and electrochemical quartz crystal microbalance (EQCM). The ultraviolet-visible (UV-Vis) spectroscopy showed a significant difference in the absorbance of PON alone and in the presence of melanin films. Finally, we report on the possibility of using the DHI-melanin film as a platform for the quantitative detection of PON in solutions. Post-print standardized by MSL Academic Endeavors, the imprint of the

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Section: Introductionmentioning

confidence: 99%