Synthetic melanin nanoparticles as peroxynitrite scavengers, photothermal anticancer and heavy metals removal platforms

Maher, Shaimaa; Mahmoud, Marwa A.; Rizk, Moustafa A.; Kalil, Haitham

doi:10.1007/s11356-019-05111-3

Cited by 20 publications

(12 citation statements)

References 79 publications

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“…As outlined above, we foresee significant potential for melanins (and analogues thereof) throughout various sectors of the economy. [ 426,617–619 ] The variety of analytical techniques available to interrogate melanins and materials/organisms containing melanins has yielded a significant body of literature on their properties that enable a variety of high value biomedical applications (summarized in a number of excellent reviews, [ 47,618,625–630 ] see Figure [ 625 ] ), demonstrating their potential for the healthcare industry in achieving the UN SDGs. [ 631 ]…”

Section: Melanins For a Sustainable Futurementioning

confidence: 99%

“…There is also significant potential for melanins as sustainably sourced feedstocks/materials for technical applications, for example, as coatings, [ 37 ] as dyes for textiles, [ 624,632–636 ] for application in environmental remediation (e.g., heavy metal, nuclear contamination/waste, etc. ), [ 629,637 ] and as sustainable components of electronic products (as emphasized in Figure 6) due to their sustainable nature and prospects for biodegradation at the end of their useful lifetime. [ 37,424,426,503,617–620,638–641 ] It is noteworthy that in 2017, 94 billion tonnes of resources were extracted worldwide and this is forecast to rise to 184 billion tonnes by 2050, which is 400% more than the Earths capacity.…”

Section: Melanins For a Sustainable Futurementioning

confidence: 99%

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Melanins as Sustainable Resources for Advanced Biotechnological Applications

et al. 2020

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Melanins are a class of biopolymers that are widespread in nature and have diverse origins, chemical compositions, and functions. Their chemical, electrical, optical, and paramagnetic properties offer opportunities for applications in materials science, particularly for medical and technical uses. This review focuses on the application of analytical techniques to study melanins in multidisciplinary contexts with a view to their use as sustainable resources for advanced biotechnological applications, and how these may facilitate the achievement of the United Nations Sustainable Development Goals.

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Section: Melanins For a Sustainable Futurementioning

confidence: 99%

Section: Melanins For a Sustainable Futurementioning

confidence: 99%

Melanins as Sustainable Resources for Advanced Biotechnological Applications

et al. 2020

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“…Melanin, an abundant biopolymer produced by most known species, has been studied in numerous fields, including medicine, microbiology, and, recently, materials chemistry and materials science. Melanin is biocompatible, bioavailable, and biodegradable with numerous reactive groups and desirable properties. , It has broadband absorption, can efficiently dissipate electromagnetic energy, possesses stable paramagnetic character, is an antioxidant, and can chelate metals and bind organic compounds. ,, These properties make melanin an ideal material for numerous applications including imaging, , photothermal applications, ,− drug delivery systems, electrodes in energy storage systems and other electronic applications, , contrast agents, UV-shielding, theranostics and other biomedical applications, − and metal scavenging . Despite its abundance in nature, melanin is primarily obtained from Sepia officinalis (cuttlefish) , ink or unicellular organisms via either in vitro or in vivo synthesis with tyrosinase. − Although the range of functional applications for melanin is vast, structural applications have lagged behind.…”

Section: Introductionmentioning

confidence: 99%

Biomorphic Ceramics: Synthesis and Characterization of Preceramic Polymer-Modified Melanin

Parvulescu

Martin

Mogilevsky

et al. 2021

ACS Biomater. Sci. Eng.

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Recent efforts have demonstrated that the morphology of ceramics can be manipulated to control both their deformation mechanism and mechanical performance. However, precise control of the ceramic nanostructure is still difficult to achieve. Biotemplating, leading to biomorphic materials, provides a facile route to manipulate the nanostructure of the resulting materials, and the use of melanin as a coating provides a new route to biotemplated materials. Melanin is underutilized for structural materials partly due to the cost of procuring it from natural sources and the inability to control the shape and sizes of melanin particles. Taking a combined synthetic biology and chemical synthesis approach, we report the melanization of Escherichia coli and its subsequent silanization and functionalization with preceramic polymers to make novel biomorphic silicon-based ceramic materials. Graft-to and graft-from reactions were used to append preceramic polymers to the melanin, followed by pyrolysis under argon. Samples were analyzed by FTIR, XRD, XPS, and TEM and found to retain the shape and size of the original cells with high fidelity. The homogeneity of coverage and yield of the resulting ceramic materials depended on the type of grafting reaction. This work provides a promising proof-of-concept that bacterial-templated ceramics can be readily made and opens a host of possibilities for further studies and applications.

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“…Melanin, another PAI contrast agent, also attracted much attention. Dopamine, a biological neurotransmitter, can form dopamine quinone structures in an alkaline environment, polymerizing into PDA, which is also known as artificial melanin (18)(19)(20)(21). In addition to PAI function, PDA is also used in nano drug delivery systems (22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma

Zhou

Lin

et al. 2021

Front. Oncol.

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At present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet the needs of patients. The integrated theranostic system, in which functional materials are used to load different active molecules, created a new developmental direction for the combination treatment of hepatic carcinoma, realizing the synchronization of diagnosis and treatment. In this study, polydopamine (PDA), which has the functions of self-assembly, encapsulation, photothermal conversion, and photoacoustic interaction, was used as the carrier material. The IR780, a near-infrared fluorescence imaging (NIFI), photoacoustic imaging (PAI), and photothermal therapy (PTT) agent, and paclitaxel (PTX), a broad-spectrum chemotherapy drug, were selected to build the NIF/PA dual-mode imaging and PTT/chemo synergistic theranostic nanoparticles (DIST NPs). The DIST NPs have a 103.4 ± 13.3 nm particle size, a weak negative charge on the surface, good colloidal stability, slow and controlled drug release, and high photothermal conversion ability. The experiments results showed that the DIST NPs have a long circulation in vivo, high bioavailability, high biocompatibility, and low effective dose. DIST NPs showed an excellent NIFI/PAI dual-mode imaging and significant synergistic antitumor effect in hepatic carcinoma models. DIST NPs met the initial design requirements. A set of fast and low-cost preparation methods was established. This study provides an experimental basis for the development of new clinical theranostic methods for hepatic carcinoma.

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Synthetic melanin nanoparticles as peroxynitrite scavengers, photothermal anticancer and heavy metals removal platforms

Cited by 20 publications

References 79 publications

Melanins as Sustainable Resources for Advanced Biotechnological Applications

Melanins as Sustainable Resources for Advanced Biotechnological Applications

Biomorphic Ceramics: Synthesis and Characterization of Preceramic Polymer-Modified Melanin

Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma

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