“…The synaptic modification rules proposed in the BCM model have been used to explain the results of many normal rearing and classical deprivation studies (Clothiaux et al, 1991;Law et al, 1994), and are also supported by a host of experimental evidence in kitten, rat, and guinea pig visual cortex (Bear et al, 1987;Greuel et al, 1988;Reiter & Stryker, 1988;Fregnac et al, 1988Fregnac et al, , 1992Artola et al, 1990;Friedlander et al, 1993;Shulz et al, 1993;Fregnac et al, 1994;Bear, 1995;Kirkwood, 1996) and in rat hippocampus (Dudek & Bear, 1992). In in vivo studies from Fregnac's group (Fregnac et al, 1988(Fregnac et al, , 1992, a differential pairing procedure was used to impose temporal correlations between visual afferent activity and postsynaptic firing induced iontophoretically.…”