Chapter 1: Lipid Microvesicles: On the Four Decades of Liposome Research

Cui, Hui‐Fang; Ye, Jianshan; Liu, Angelica Leitmannova; Tien, H. Ti

doi:10.1016/s1554-4516(06)04001-4

Cited by 4 publications

(2 citation statements)

References 240 publications

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“…Unilamellar liposomes are artificially prepared spherical containers comprising of a phospholipid bilayer shell and an aqueous core (Bangham et al ., ; Tien & Ottova‐Leitmannova, ; Cui et al ., ). In the latter, biologically active molecules such as hydrophilic drugs can be stored and transported, whereas the lipidic shell can be loaded with hydrophobic drugs.…”

Section: Applicationsmentioning

confidence: 97%

S-layers: principles and applications

et al. 2014

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Monomolecular arrays of protein or glycoprotein subunits forming surface layers (S-layers) are one of the most commonly observed prokaryotic cell envelope components. S-layers are generally the most abundantly expressed proteins, have been observed in species of nearly every taxonomical group of walled bacteria, and represent an almost universal feature of archaeal envelopes. The isoporous lattices completely covering the cell surface provide organisms with various selection advantages including functioning as protective coats, molecular sieves and ion traps, as structures involved in surface recognition and cell adhesion, and as antifouling layers. S-layers are also identified to contribute to virulence when present as a structural component of pathogens. In Archaea, most of which possess S-layers as exclusive wall component, they are involved in determining cell shape and cell division. Studies on structure, chemistry, genetics, assembly, function, and evolutionary relationship of S-layers revealed considerable application potential in (nano)biotechnology, biomimetics, biomedicine, and synthetic biology.

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Section: Applicationsmentioning

confidence: 97%

S-layers: principles and applications

et al. 2014

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“…Unilamellar liposomes are artificially prepared spherical containers comprising a phospholipid bilayer shell and an aqueous core (figure 4c, right-hand side) [221][222][223]. Hydrophilic drugs can be stored and transported in the core, whereas the lipidic shell can be loaded with hydrophobic drugs.…”

Section: Spherical Lipid Membranes (Liposomes and Emulsomes)mentioning

confidence: 99%

Biomimetic interfaces based on S-layer proteins, lipid membranes and functional biomolecules

Schuster

Sleytr

2014

J. R. Soc. Interface.

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Designing and utilization of biomimetic membrane systems generated by bottom-up processes is a rapidly growing scientific and engineering field. Elucidation of the supramolecular construction principle of archaeal cell envelopes composed of S-layer stabilized lipid membranes led to new strategies for generating highly stable functional lipid membranes at mesoand macroscopic scale. In this review, we provide a state-of-the-art survey of how S-layer proteins, lipids and polymers may be used as basic building blocks for the assembly of S-layer-supported lipid membranes. These biomimetic membrane systems are distinguished by a nanopatterned fluidity, enhanced stability and longevity and, thus, provide a dedicated reconstitution matrix for membrane-active peptides and transmembrane proteins. Exciting areas in the (lab-on-a-) biochip technology are combining composite S-layer membrane systems involving specific membrane functions with the silicon world. Thus, it might become possible to create artificial noses or tongues, where many receptor proteins have to be exposed and read out simultaneously. Moreover, S-layer-coated liposomes and emulsomes copying virus envelopes constitute promising nanoformulations for the production of novel targeting, delivery, encapsulation and imaging systems.

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