A multivariate analysis investigating different factors important for the interaction between liposomes and pectin

Alund, Siv Jorunn; Smistad, Gro; Hiorth, Marianne

doi:10.1016/j.colsurfa.2012.11.079

Cited by 21 publications

(10 citation statements)

References 24 publications

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“…The negatively charged pectin-coated liposomes showed high stability without aggregation in the artificial saliva and were suggested as promising formulations to be used as a tooth adhesive nanosystem, providing improved treatment of tooth ailments. Similar conclusions were reported by other researchers, who have also studied the potential use of pectin in the formulation of liposomes [79][80][81].…”

Section: Pectinsupporting

confidence: 91%

Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

et al. 2021

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The intensive development of micro- and nanotechnologies in recent years has offered a wide horizon of new possibilities for drug delivery in dentistry. The use of polymeric drug carriers turned out to be a very successful technique for formulating micro- and nanoparticles with controlled or targeted drug release in the oral cavity. Such innovative strategies have the potential to provide an improved therapeutic approach to prevention and treatment of various oral diseases not only for adults, but also in the pediatric dental practice. Due to their biocompatibility, biotolerance and biodegradability, naturally occurring polysaccharides like chitosan, alginate, pectin, dextran, starch, etc., are among the most preferred materials for preparation of micro- and nano-devices for drug delivery, offering simple particle-forming characteristics and easily tunable properties of the formulated structures. Their low immunogenicity and low toxicity provide an advantage over most synthetic polymers for the development of pediatric formulations. This review is focused on micro- and nanoscale polysaccharide biomaterials as dental drug carriers, with an emphasis on their potential application in pediatric dentistry.

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Section: Pectinsupporting

confidence: 91%

Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

et al. 2021

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“…Further investigation combined with TEM was required to confirm this. The growth in particle size was possibly caused by the aggregations of free particles via bridging flocculation during the process of adding pectin or chitosan . A size increase was also possible if forming the structure of the polymer–particle network as large aggregates consisting of polymeric chains with multiple particles imbedded .…”

Section: Discussionmentioning

confidence: 99%

Preparation, Optimization and Characterization of Bovine Lactoferrin‐loaded Liposomes and Solid Lipid Particles Modified by Hydrophilic Polymers Using Factorial Design

et al. 2014

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Bioadhesive liposomes and solid lipid particles (SLPs) modified by pectin and chitosan for oral administration of bovine lactoferrin (bLf) were prepared using a 2(4) full-factorial design to identify the key formulation variables influencing particle size and drug entrapment efficiency (EE). Netlike structures of the polymer-particle mixture consisting of a polymeric network in which multiple particles were imbedded were observed by scanning electron microscopy (SEM). Chemical stability of bLf after encapsulation into pectin- and chitosan-modified liposomes and SLPs was confirmed by Fourier transform infrared spectra (FTIR). Bovine lactoferrin was located within phospholipid bilayer, whereas in SLPs bLf was within the matrix. The crystalline nature of bLf after encapsulation was investigated by differential scanning calorimetry (DSC) of drug-loaded particles, indicating amorphous dispersion of bLf in the polymer-lipid matrix of pectin- and chitosan-modified liposomes and SLPs. In vivo pharmacokinetic investigation of bLf in pectin- and chitosan-modified liposomes and SLPs showed prolonged mean residence time (MRT) of bLf in rat blood and increased the relative bioavailability (Fbio %) by 1.95- to 2.69-fold compared with free bLf. The developed carrier systems are considered to be promising vehicles for oral delivery.

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“…Liposomes can protect the active component from in vivo degradation, regulate release rate and reduce the toxicity of the encapsulated drug (Han et al, 2012). Liposomes are composed of various lipids and can additionally be coated with different types of polymers, which introduces a great degree of flexibility to the properties of the obtained nanocarriers (Alund et al, 2013;Smistad et al, 2012). A commercially successful example of a coated liposome formulation is Caelyx®; an intravenous injection containing doxorubicin for cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells

Adamczak

Hagesæther

Smistad

et al. 2016

International Journal of Pharmaceutics

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Drug delivery to the oral cavity poses a significant challenge due to the short residence time of the formulations at the site of action. From this point of view, nanoparticulate drug delivery systems with ability to adhere to the oral mucosa are advantageous as they could increase the effectiveness of the therapy. Positively, negatively and neutrally charged liposomes were coated with four different types of polymers: alginate, low-ester pectin, chitosan and hydrophobically modified ethyl hydroxyethyl cellulose. The mucoadhesion was studied using a novel in vitro method allowing the liposomes to interact with a mucus-producing confluent HT29-MTX cell-line without applying any external force. MTT viability and paracellular permeability tests were conducted on the same cell-line. The alginate-coated liposomes achieved a high specific (genuine) mucin interaction, with a low potential of cell-irritation. The positively charged uncoated liposomes achieved the highest initial mucoadhesion, but also displayed a higher probability of cell-irritation. The chitosan-coated liposomes displayed the highest potential for long lasting mucoadhesion, but with the drawback of a higher general adhesion (tack) and a higher potential for irritating the cells.

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A multivariate analysis investigating different factors important for the interaction between liposomes and pectin

Cited by 21 publications

References 24 publications

Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

Polysaccharide-Based Micro- and Nanosized Drug Delivery Systems for Potential Application in the Pediatric Dentistry

Preparation, Optimization and Characterization of Bovine Lactoferrin‐loaded Liposomes and Solid Lipid Particles Modified by Hydrophilic Polymers Using Factorial Design

An in vitro study of mucoadhesion and biocompatibility of polymer coated liposomes on HT29-MTX mucus-producing cells

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