Chaperone-like α-cyclodextrins assisted self-assembly of double hydrophilic block copolymers in aqueous medium

Liu, Yang; Zhao, Dongyun; Ma, Rujiang; Xiong, Dean; An, Yingli; Shi, Linqi

doi:10.1016/j.polymer.2008.12.005

Cited by 23 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondly, when energy is supplied by shaking, the film curves and surrounds the oily globules to form an oil-water emulsion. Then, due to the interaction between b-CD and fish oil, CD molecules crystallize around the oily globules (Trichard et al, 2008;Liu et al, 2009). At the same time, fish oil may exist randomly among the precipitated b-CD to promote the formation of supramolecules, especially in the presence of increasing concentrations of fish oil.…”

Section: Discussionmentioning

confidence: 99%

Morphological characterization of encapsulated fish oil with β-cyclodextrin and polycaprolactone

Choi

Ruktanonchai

Soottitantawat

et al. 2009

Food Research International

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Morphological characterization of encapsulated fish oil with β-cyclodextrin and polycaprolactone

Choi

Ruktanonchai

Soottitantawat

et al. 2009

Food Research International

View full text Add to dashboard Cite

“…The core-shell structured micelles with a hydrophobic core can efficiently load prednisone acetate and sustain its release for 700 h [130]. Via inclusion complexation of α-CD and PEG, cytocompatible vesicles can be assembled by PEG-containing block or graft copolymers [131-134]. These hollow nanospheres may encapsulate enzymes and other hydrophilic drugs, and the drug-loaded assemblies exhibited better in vitro efficacy compared with the free therapeutics.…”

Section: Nanomedicines Assembled By Cyclodextrin Derivativesmentioning

confidence: 99%

Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective

Zhang

Peter

2013

Advanced Drug Delivery Reviews

721

596

View full text Add to dashboard Cite

The excellent biocompatibility and unique inclusion capability as well as powerful functionalization capacity of cyclodextrins and their derivatives make them especially attractive for engineering novel functional materials for biomedical applications. There has been increasing interest recently to fabricate supramolecular systems for drug and gene delivery based on cyclodextrin materials. This review focuses on state of the art and recent advances in the construction of cyclodextrin-based assemblies and their applications for controlled drug delivery. First, we introduce cyclodextrin materials utilized for self-assembly. The fabrication technologies of supramolecular systems including nanoplatforms and hydrogels as well as their applications in nanomedicine and pharmaceutical sciences are then highlighted. At the end, the future directions of this field are discussed.

show abstract

“…al. [14] demonstrated that stimuli-responsive polyrotaxanes made from α-CD and a diblock PEO-b-P4VP copolymer can function as a molecular piston. However, research reports on the direct utilization of the CDs for the fabrication of diblock copolymerbased nanomaterials which may be used as drug encapsulators are scarce.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Chuang

Prasannan³

et al. 2015

J Polym Res

View full text Add to dashboard Cite

A novel method has been used to prepare the selfassembled supramolecular micelles which aid in the delivery of anticancer drugs. α-Cyclodextrin (α-CD) induces a micellization process of poly(ε-caprolactone-block-4-vinylpyridine) (PCL-b-P4VP) copolymers through selective inclusion of PCL segments into the cavity of α-CD, resulting in the formation of pseudopolyrotaxane-b-P4VP. Compound pseudopolyrotaxane-b-P4VP forms supramolecular micelles in aqueous medium through self-assembly, which has been characterized using various analytical techniques. The resultant complex micelles consist of pseudopolyrotaxane as the core and P4VP chains in the outer shell, and the micelles possess a well-defined spherical morphology. The selfassembly process can easily be tailor-made by varying the number of PCL and P4VP segments in the PCL x -b-P4VP y copolymer. The arrangement of pseudopolyrotaxane-b-P4VP in the form of Bchannel-type^crystallites (derived from the supramolecular columns) is confirmed from the wide-angle X-ray diffraction (WAXD) patterns as well as by the composition of the inclusion complexes (ICs) calculated via proton nuclear magnetic resonance ( 1 H NMR) spectral data. The biocompatibility of the micelles was evaluated by a cell viability test and the results revealed excellent cytocompatibility. The prepared micelles were used as carriers for the model anticancer drug doxorubicin (DOX) and successful drug release was observed with a loading content of 14.4 % (w/w) and a loading efficiency of 28.9 %. In vitro drug delivery was evaluated in phosphate-buffered saline (PBS) solution. DOX release from the micelles was considerably faster at pH 5.0 in comparison to a physiological pH of 7.4. The development of supramolecular self-assembled micelles based on partial IC formation between α-CD and compatible block copolymers opens a new, facile and attractive approach for designing novel drug carriers for future pharmaceutical applications.

show abstract

Chaperone-like α-cyclodextrins assisted self-assembly of double hydrophilic block copolymers in aqueous medium

Cited by 23 publications

References 38 publications

Morphological characterization of encapsulated fish oil with β-cyclodextrin and polycaprolactone

Morphological characterization of encapsulated fish oil with β-cyclodextrin and polycaprolactone

Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective

Preparation of a drug carrier through α-cyclodextrin-induced micellization of poly(ε-caprolactone-block-4-vinylpyridine) for controlled delivery of doxorubicin

Contact Info

Product

Resources

About