Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective

Zhang, Jianxiang; Peter, X.

doi:10.1016/j.addr.2013.05.001

Cited by 720 publications

(614 citation statements)

References 216 publications

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“…Cyclodextrins are a family of cyclic sugars that are commonly used to solubilize hydrophobic drugs (29)(30)(31)(32). They possess a hydrophobic cavity and a hydrophilic surface and are known to stably encapsulate a large variety of hydrophobic organic molecules in aqueous media.…”

mentioning

confidence: 99%

Remote loading of preencapsulated drugs into stealth liposomes

Sur

Fries

Kinzler

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

122

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Loading drugs into carriers such as liposomes can increase the therapeutic ratio by reducing drug concentrations in normal tissues and raising their concentrations in tumors. Although this strategy has proven advantageous in certain circumstances, many drugs are highly hydrophobic and nonionizable and cannot be loaded into liposomes through conventional means. We hypothesized that such drugs could be actively loaded into liposomes by encapsulating them into specially designed cyclodextrins. To test this hypothesis, two hydrophobic drugs that had failed phase II clinical trials because of excess toxicity at deliverable doses were evaluated. In both cases, the drugs could be remotely loaded into liposomes after their encapsulation (preloading) into cyclodextrins and administered to mice at higher doses and with greater efficacy than possible with the free drugs.T here is currently wide interest in the development of nanoparticles for drug delivery (1-7). This area of research is particularly relevant to cancer drugs, wherein the therapeutic ratio (dose required for effectiveness to dose causing toxicity) is often low. Nanoparticles carrying drugs can increase this therapeutic ratio over that achieved with the free drug through several mechanisms. In particular, drugs delivered by nanoparticles are thought to selectively enhance the concentration of the drugs in tumors as a result of the enhanced permeability and retention (EPR) effect (8-18). The enhanced permeability results from a leaky tumor vascular system, whereas the enhanced retention results from the disorganized lymphatic system that is characteristic of malignant tumors.Much current work in this field is devoted to designing novel materials for nanoparticle generation. This new generation of nanoparticles can carry drugs-particularly those that are insoluble in aqueous medium-that are difficult to incorporate into conventional nanoparticles such as liposomes. However, the older generation of nanoparticles has a major practical advantage in that they have been extensively tested in humans and approved by regulatory agencies such as the Food and Drug Administration in the United States and the European Medicines Agency in Europe. Unfortunately, many drugs cannot be easily or effectively loaded into liposomes, thereby compromising their general use.In general, liposomal drug loading is achieved by either passive or active methods (9,(19)(20)(21)(22). Passive loading involves dissolution of dried lipid films in aqueous solutions containing the drug of interest. This approach can only be used for water-soluble drugs, and the efficiency of loading is often low. In contrast, active loading can be extremely efficient, resulting in high intraliposomal concentrations and minimal wastage of precious chemotherapeutic agents (9,23,24). In active loading, drug internalization into preformed liposomes is typically driven by a transmembrane pH gradient. The pH outside the liposome allows some of the drug to exist in an unionized form, able to migrate across the lipid bi...

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mentioning

confidence: 99%

Remote loading of preencapsulated drugs into stealth liposomes

Sur

Fries

Kinzler

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

122

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“…Upon the addition of 100µl of 100 mM uric acid, urea, and ascorbic acid respectively to 0.1 mM DA solution. The results indicate that, such interference is not significantly affecting the DA signal intensity which is attributed to the pores size of ionophore β-CD that has a cage-like supramolecular structure, and hydrophobic cavity which could permit certain molecules to pass and prevents the others [43]. It is worth mentioning that, the pore diameter of the β-CD is ~0.7 nm and for the DA is around 0.5 nm i.e., benzene ring size and possibly all the interfering compounds examined in this work were less than the β-CD diameter.…”

Section: Electrochemical Measurementsmentioning

confidence: 75%

Dopamine wide range detection sensor based on modified Co3O4 nanowires electrode

Elhag

Ibupoto

Liu

et al. 2014

Sensors and Actuators B: Chemical

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Ultra-thin cobalt oxide (Co3O4) nanowires grown on gold coated glass substrates by the hydrothermal chemical deposition and have been used as a wide range dopamine potentiometric sensor. An anionic surfactant (sodium dodecylbenzenesulfonate) was used to achieve assisted growth procedure. Moreover, a polymeric membrane containing polyvinyl chloride as plasticized polymer, β-cyclodextrin as ionophore, and potassium tetrakis (4-chlorophenyl) borate as ionic additive were immobilized on the Co3O4 nanostructures through electrostatic adsorption method. X-ray diffraction, x-ray photoelectron spectroscopy, and scanning electron microscopy were used to characterize the electrodes while ultravioletvisible absorption was used to investigate the band gap of the Co3O4 nanostructures. The structural characterization showed a cubic crystalline, pure phase, and nanowires morphology of the Co3O4. However, the morphology is altered when the surfactant concentration has been changed. The Co3O4 chemical modified electrodes were used in potentiometric measurements for dopamine in a 10 −2 M acetic acid/sodium acetate solution having a pH of 5.45. For dopamine range from 10 -9 M to 10 -2 M, the potential response of the sensor electrode was linear with a slope of 52mV/decade. The wide range and high sensitivity of the modified Co3O4 nanowires based sensor for dopamine is attributed to the defects on the metal oxide that is dictated by the used surfactant along with the high surface area-to-volume ratio.

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“…Although natural cyclodextrins (the best known cyclodextrins include α-, β-, and γ-cyclodextrin) are of interest for the development of pharmaceutical formulations by presenting excellent biocompatibility, 194 the ability to mask undesirable organoleptic properties of drugs, and the ability to increase solubility and permeability, 195 these compounds demonstrate limitations for the transport of drugs, enabling the loading of only lipophilic drugs by virtue of the cyclodextrin hydrophilic exterior and interior hydrophobic cavity. 196 Soon, natural cyclodextrins may be produced with chemical modifications in accordance with the interest in this field, 197 enabling the attainment of cyclodextrins with both lipophilic and conjugated polar groups, making them amphiphilic.…”

Section: Complexes Of Cyclodextrinsmentioning

confidence: 99%

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Calixto¹,

Fonseca-Santos²,

Chorilli³

et al. 2014

IJN

146

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Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment methods (oral cavity and oropharynx) nanotechnology, which involves the design, characterization, production, and application of nanoscale drug delivery systems. In medicine, nanotechnologies, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, hydrogels, cyclodextrin complexes, and liquid crystals, are promising tools for diagnostic probes and therapeutic devices. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for oral cancers.

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Cyclodextrin-based supramolecular systems for drug delivery: Recent progress and future perspective

Cited by 720 publications

References 216 publications

Remote loading of preencapsulated drugs into stealth liposomes

Remote loading of preencapsulated drugs into stealth liposomes

Dopamine wide range detection sensor based on modified Co3O4 nanowires electrode

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

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