Channelrhodopsins—Their potential in gene therapy for neurological disorders

Ji, Zhi Gang; Ishizuka, Toru; Yawo, Hiromu

doi:10.1016/j.neures.2012.09.004

Cited by 10 publications

(5 citation statements)

References 95 publications

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“…Optogenetics has been widely used to study neural and non-neural functions (Miesenböck, 2011;Yawo et al, 2013). Recently, it was also used to investigate and treat neurological diseases such as blindness and spinal cord injury (Ji et al, 2013). Numerous experiments have indicated that an optogenetic approach could overcome the above shortcomings and provide a promising strategy to treat epilepsy.…”

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confidence: 99%

Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

Wang

2015

Brain Research Bulletin

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confidence: 99%

Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

Wang

2015

Brain Research Bulletin

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“…The activation of ChR2 in astrocytes can lead to depolarization, intracellular pH reduction, and an increase in [Ca 2+ ]. These changes can significantly influence astrocyte activity and modulate the release of gliotransmitters (Figure 2) [36].…”

Section: Optogenetics As a Tool For Regulating The Activity Of Nerve ...mentioning

confidence: 99%

Optogenetics in Alzheimer’s Disease: Focus on Astrocytes

Mitroshina,

Kalinina,

Vedunova

2023

Antioxidants

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Alzheimer’s disease (AD) is the most common form of dementia, resulting in disability and mortality. The global incidence of AD is consistently surging. Although numerous therapeutic agents with promising potential have been developed, none have successfully treated AD to date. Consequently, the pursuit of novel methodologies to address neurodegenerative processes in AD remains a paramount endeavor. A particularly promising avenue in this search is optogenetics, enabling the manipulation of neuronal activity. In recent years, research attention has pivoted from neurons to glial cells. This review aims to consider the potential of the optogenetic correction of astrocyte metabolism as a promising strategy for correcting AD-related disorders. The initial segment of the review centers on the role of astrocytes in the genesis of neurodegeneration. Astrocytes have been implicated in several pathological processes associated with AD, encompassing the clearance of β-amyloid, neuroinflammation, excitotoxicity, oxidative stress, and lipid metabolism (along with a critical role in apolipoprotein E function). The effect of astrocyte–neuronal interactions will also be scrutinized. Furthermore, the review delves into a number of studies indicating that changes in cellular calcium (Ca2+) signaling are one of the causes of neurodegeneration. The review’s latter section presents insights into the application of various optogenetic tools to manipulate astrocytic function as a means to counteract neurodegenerative changes.

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“…The animal studies described above give a glimpse at future possibilities for human therapies, but there are several hurdles to be overcome for clinical applications of optogenetics, such as target specificity, safety, long-term effectiveness, and optimal light delivery [79]. In mice, a cell type- or tissue-specific opsin protein expression is achieved mainly by the transgenic Cre-LoxP system, but this is not applicable to humans or most other species.…”

Section: Peripheral Neuromodulation Of Adipose Tissuementioning

confidence: 99%

Genetics-based manipulation of adipose tissue sympathetic innervation

François

Qualls‐Creekmore

Berthoud

et al. 2018

Physiology & Behavior

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There is renewed interest in leveraging the thermogenic capacity of brown adipose tissue (BAT) and browning of white adipose tissue (WAT) to improve energy balance and prevent obesity. In addition to these effects on energy expenditure, both BAT and WAT secrete large numbers of hormones and cytokines that play important roles in maintaining metabolic health. Both BAT and WAT are densely innervated by the sympathetic nervous system (SNS) and this innervation is crucial for BAT thermogenesis and WAT browning, making it a potentially interesting target for manipulating energy balance and treatment of obesity and metabolic disease. Peripheral neuromodulation in the form of electrical manipulation of the SNS and parasympathetic nervous system (PSNS) has been used for the management of pain and many other conditions, but progress is hampered by lack of detailed knowledge of function-specific neurons and nerves innervating particular organs and tissues. Therefore, the goal of the National Institutes of Health (NIH) Common Fund project "Stimulating Peripheral Activity to Relieve Conditions (SPARC)" is to comprehensively map both anatomical and neurochemical aspects of the peripheral nervous system in animal model systems to ultimately guide optimal neuromodulation strategies in humans. Compared to electrical manipulation, neuron-specific opto- and chemogenetic manipulation, now being extensively used to decode the function of brain circuits, will further increase the functional specificity of peripheral neuromodulation.

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Channelrhodopsins—Their potential in gene therapy for neurological disorders

Cited by 10 publications

References 95 publications

Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

Optogenetics in Alzheimer’s Disease: Focus on Astrocytes

Genetics-based manipulation of adipose tissue sympathetic innervation

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