Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

Ji, Zhigang; Wang, Hongxia

doi:10.1016/j.brainresbull.2014.10.013

Cited by 23 publications

(16 citation statements)

References 66 publications

(73 reference statements)

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“…This phenomenon might be explained with the possible swelling of astrocytes during optogenetic activation. As opening of the ChR2 results influx of Na + , Ca 2+ and H + , it might result influx of water and swelling-dependent gliotransmitter release via VRAC channels (Abdullaev et al, 2006 ; Kozlov et al, 2006 ; Gourine et al, 2010 ; Figueiredo et al, 2011 ; Beppu et al, 2014 ; Perea et al, 2014 ; Ji and Wang, 2015 ). Similarly slower SICs were recorded in hypoosmotic solution where the swelling of astrocytes was quantified.…”

Section: Discussionmentioning

confidence: 99%

Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN)

Kovács

Pál

2017

Front. Cell. Neurosci.

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Slow inward currents (SICs) are known as excitatory events of neurons caused by astrocytic glutamate release and consequential activation of neuronal extrasynaptic NMDA receptors. In the present article we investigate the role of these astrocyte-dependent excitatory events on a cholinergic nucleus of the reticular activating system (RAS), the pedunculopontine nucleus (PPN). It is well known about this and other elements of the RAS, that they do not only give rise to neuromodulatory innervation of several areas, but also targets neuromodulatory actions from other members of the RAS or factors providing the homeostatic drive for sleep. Using slice electrophysiology, optogenetics and morphological reconstruction, we revealed that SICs are present in a population of PPN neurons. The frequency of SICs recorded on PPN neurons was higher when the soma of the given neuron was close to an astrocytic soma. SICs do not appear simultaneously on neighboring neurons, thus it is unlikely that they synchronize neuronal activity in this structure. Occurrence of SICs is regulated by cannabinoid, muscarinic and serotonergic neuromodulatory mechanisms. In most cases, SICs occurred independently from tonic neuronal currents. SICs were affected by different neuromodulatory agents in a rather uniform way: if control SIC activity was low, the applied drugs increased it, but if SIC activity was increased in control, the same drugs lowered it. SICs of PPN neurons possibly represent a mechanism which elicits network-independent spikes on certain PPN neurons; forming an alternative, astrocyte-dependent pathway of neuromodulatory mechanisms.

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Section: Discussionmentioning

confidence: 99%

Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN)

Kovács

Pál

2017

Front. Cell. Neurosci.

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“…Astrocytes in hippocampal slices of human patients suffering from temporal lobe epilepsy displayed prolonged depolarization and reduced inward rectifier currents (Hinterkeuser et al, 2000), implicating K+ homeostasis as an important contributor to epilepsy. Optogenetics may provide promising therapeutic potential to correct astrocytic glutamate and K+ uptake in epilepsy (Ji and Wang, 2015). Furthermore, proper functioning of gap junctions and inter-astrocytic communication are believed to play a role in the development of epilepsy, but their exact role is still unknown.…”

Section: Astrocytes In Neuropathologiesmentioning

confidence: 99%

“Targeting astrocytes in CNS injury and disease: A translational research approach”

Filous

Silver

2016

Progress in Neurobiology

135

104

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Astrocytes are a major constituent of the central nervous system. These glia play a major role in regulating blood-brain barrier function, the formation and maintenance of synapses, glutamate uptake, and trophic support for surrounding neurons and glia. Therefore, maintaining the proper functioning of these cells is crucial to survival. Astrocyte defects are associated with a wide variety of neuropathological insults, ranging from neurodegenerative diseases to gliomas. Additionally, injury to the CNS causes drastic changes to astrocytes, often leading to a phenomenon known as reactive astrogliosis. This process is important for protecting the surrounding healthy tissue from the spread of injury, while it also inhibits axonal regeneration and plasticity. Here, we discuss the important roles of astrocytes after injury and in disease, as well as potential therapeutic approaches to restore proper astrocyte functioning.

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“…Optogenetics therapy for conditions such as depression [ 117 ], chronic pain [ 118 , 119 ] and laryngeal paralysis [ 120 ] has been tested. Besides, numerous studies utilizing optogenetics in cardio cerebral diseases have shown great potential for treating cardiac diseases [ 121 , 122 ], epilepsy [ 123 , 124 , 125 ], Parkinson’s [ 126 ] and Alzheimer’s diseases [ 127 ]. However, due to the sheer complexity of the human brain, there exists a remote distance of further study for human use.…”

Section: Photomedicine Based On Biocompatible Optical Devicesmentioning

confidence: 99%

Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

Wang

Dong

2020

Sensors

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Optical waveguides and integrated optical devices are promising solutions for many applications, such as medical diagnosis, health monitoring and light therapies. Despite the many existing reviews focusing on the materials that these devices are made from, a systematic review that relates these devices to the various materials, fabrication processes, sensing methods and medical applications is still seldom seen. This work is intended to link these multidisciplinary fields, and to provide a comprehensive review of the recent advances of these devices. Firstly, the optical and mechanical properties of optical waveguides based on glass, polymers and heterogeneous materials and fabricated via various processes are thoroughly discussed, together with their applications for medical purposes. Then, the fabrication processes and medical implementations of integrated passive and active optical devices with sensing modules are introduced, which can be used in many medical fields such as drug delivery and cardiovascular healthcare. Thirdly, wearable optical sensing devices based on light sensing methods such as colorimetry, fluorescence and luminescence are discussed. Additionally, the wearable optical devices for light therapies are introduced. The review concludes with a comprehensive summary of these optical devices, in terms of their forms, materials, light sources and applications.

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Optogenetic control of astrocytes: Is it possible to treat astrocyte-related epilepsy?

Cited by 23 publications

References 66 publications

Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN)

Astrocyte-Dependent Slow Inward Currents (SICs) Participate in Neuromodulatory Mechanisms in the Pedunculopontine Nucleus (PPN)

“Targeting astrocytes in CNS injury and disease: A translational research approach”

Optical Waveguides and Integrated Optical Devices for Medical Diagnosis, Health Monitoring and Light Therapies

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